SLC1A1 and EWSR1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SLC1A1	EWSR1
Gene Name		solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	EWS RNA-binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Vesicular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane
	Molecular Function	L-glutamate Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Sodium:dicarboxylate Symporter Activity Cysteine Transmembrane Transporter Activity	Nucleotide Binding RNA Binding Protein Binding Calmodulin Binding Zinc Ion Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Ion Transport Synaptic Transmission Cysteine Transport Protein Homooligomerization L-glutamate Import Transmembrane Transport D-aspartate Import L-glutamate Transmembrane Transport	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs		L-Aspartic Acid L-Glutamic Acid
Diseases
GWAS		Pancreatic cancer ( 22158540)	Breast cancer ( 23535729)
Protein-Protein Interactions		6 interactors: APP ARL6IP5 EWSR1 LDLRAD1 PRKCA RNF5	159 interactors: ACTL6A AGT ATN1 ATPAF2 ATXN3 BAD BARD1 BLZF1 BNIP3L BTK C10orf12 C11orf16 C19orf57 CALM1 CCDC91 CD177 CDK12 CEACAM5 CETP CFDP1 CHERP CNST CPSF6 CPSF7 CREBBP CUEDC2 CXADR DFFA DHX9 DMRTB1 DNAJB3 DYNLL2 E2F8 ECD ELAVL3 ELAVL4 ELK1 EP300 EPAS1 EPT1 ERCC5 FAM131C FASN FLI1 FUS FXR2 GNPDA1 GPBP1L1 HBP1 HDAC3 HERPUD1 HIST1H2BN HLTF HMGA1 HMGN4 HNRNPUL1 HSPA2 IRF3 ITCH ITGB5 JUN KCNMB1 KEL KHDRBS2 KRR1 KXD1 LILRA3 MAGEA11 MAPK1IP1L MATK MDFI MNS1 MRPS18B MSC MTCP1 MTMR9 MVK MYL6 MYO1F MYOZ2 NBPF3 NDRG1 NDUFB1 NDUFV1 NINL NLE1 NONO NPPB NSUN4 NTNG2 PCBP1 PDHX PEF1 PGLS PLSCR1 POLR2G POLR3A POU4F1 POU5F1 PRKCA PRMT1 PRR13 PRRC2A PRTFDC1 PRUNE2 PTK2B RAB37 RAD23A RALYL RASL11B RBPMS RFX3 RHOXF2 RMND5B RNF183 RPL31 RPS15A SALL2 SCMH1 SEC24A SEC24D SERP2 SF1 SF3B4 SLC1A1 SLC22A24 SMAD1 SMAD4 SNRPC SSBP2 SSBP3 SUPT4H1 SUV39H2 TAF1 TFG TMSB4Y TONSL TPGS2 TRAF1 TRAF2 TRAF3 TRIM37 TRIM5 TRPV5 TSPAN3 TULP2 USP7 VPS72 WBP4 WDR37 WWP1 WWP2 YWHAG YY1AP1 ZBTB1 ZDHHC3 ZNF165 ZNF184 ZNF383
Entrez ID		6505	2130
HPRD ID		00597	00592
Ensembl ID		ENSG00000106688	ENSG00000182944
Uniprot IDs		P43005	Q01844
PDB IDs			2CPE
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Histone H3-T6 Phosphorylation Collateral Sprouting In Absence Of Injury ER-associated Misfolded Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Apoptotic Process Platelet Activation Programmed Cell Death Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Hydrolase Activity Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Peptidyl-serine Autophosphorylation Axon Choice Point Recognition Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cell Cycle Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Regulation Of Phosphorylation Calcium Ion Homeostasis Neuron Remodeling Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Response To Light Stimulus Response To Stress Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Negative Regulation Of Glucose Import Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Macrophage Differentiation Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Desmosome Organization Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Membrane Potential Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Misfolded Or Incompletely Synthesized Protein Catabolic Process	RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Nitrogen Compound Metabolic Process Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Stress Viral Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter RNA Processing Negative Regulation Of Gene Expression Cellular Response To Stress Regulation Of Establishment Of Protein Localization Negative Regulation Of Transcription, DNA-templated MRNA Metabolic Process MRNA Processing Apoptotic Process Regulation Of Intracellular Transport Response To Virus Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Localization Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Transport Immune System Process Regulation Of Protein Localization Cell Death Defense Response Death Regulation Of Cell Death
Tagcloud ?		agonist am80 anionic atra c6 carrier counterpart eaac1 eaat3 encodes glioma hx630 intermediate le540 markedly messenger mimicked mrnas rarb rarbeta rfx1 rodent rxr silencing stimulates trafficking trans transporter unchanged	arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1
Tagcloud (Difference) ?		agonist am80 anionic atra c6 carrier counterpart eaac1 eaat3 encodes glioma hx630 intermediate le540 markedly messenger mimicked mrnas rarb rarbeta rfx1 rodent rxr silencing stimulates trafficking trans transporter unchanged	arranged blue cauda cd99 cords equina focal fusion glomus hybridization immunophenotypic indolent infrequent involving ki labeling longstanding mitoses nerve nests neu reverse roots rosette round smooth spinal transcriptase wt1
Tagcloud (Intersection) ?