SLC1A1 and LDLRAD1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SLC1A1	LDLRAD1
Gene Name		solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	low density lipoprotein receptor class A domain containing 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Vesicular Exosome	Integral Component Of Membrane
	Molecular Function	L-glutamate Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Sodium:dicarboxylate Symporter Activity Cysteine Transmembrane Transporter Activity
	Biological Process	Ion Transport Synaptic Transmission Cysteine Transport Protein Homooligomerization L-glutamate Import Transmembrane Transport D-aspartate Import L-glutamate Transmembrane Transport
Pathways		Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs		L-Aspartic Acid L-Glutamic Acid
Diseases
GWAS		Pancreatic cancer ( 22158540)
Protein-Protein Interactions		6 interactors: APP ARL6IP5 EWSR1 LDLRAD1 PRKCA RNF5	16 interactors: BNIP3 BNIP3L GIMAP5 GPR128 LAPTM5 MAL MALL MARCH2 OLFM4 PLN PTTG1IP SLC1A1 TMEM147 TMEM190 TMEM218 VTI1B
Entrez ID		6505	388633
HPRD ID		00597	17372
Ensembl ID		ENSG00000106688
Uniprot IDs		P43005	B7ZME3 Q5T700
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Histone H3-T6 Phosphorylation Collateral Sprouting In Absence Of Injury ER-associated Misfolded Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Apoptotic Process Platelet Activation Programmed Cell Death Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Hydrolase Activity Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Peptidyl-serine Autophosphorylation Axon Choice Point Recognition Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cell Cycle Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Regulation Of Phosphorylation Calcium Ion Homeostasis Neuron Remodeling Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Response To Light Stimulus Response To Stress Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Negative Regulation Of Glucose Import Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Macrophage Differentiation Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Desmosome Organization Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Membrane Potential Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Misfolded Or Incompletely Synthesized Protein Catabolic Process	Mitochondrial Protein Catabolic Process Mitochondrial Outer Membrane Permeabilization Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Defense Response To Virus Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Transport Protein Homooligomerization Response To Virus Mitochondrial Membrane Organization Cysteine Transport Positive Regulation Of Interleukin-15 Production Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Negative Regulation Of Calcium Ion Import Into Sarcoplasmic Reticulum Cytotoxic T Cell Differentiation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Calcium-transporting ATPase Activity TIRAP-dependent Toll-like Receptor 4 Signaling Pathway Apoptotic Mitochondrial Changes Membrane Organization Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Calcium Ion Binding Regulation Of The Force Of Heart Contraction By Cardiac Conduction Protein Oligomerization Positive Regulation Of Toll-like Receptor 3 Signaling Pathway Membrane Raft Polarization Regulation Of Calcium-transporting ATPase Activity D-aspartate Import Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Membrane Raft Localization Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway Mitochondrial Transport Negative Regulation Of Calcium Ion Import Autophagic Cell Death Regulation Of Mitochondrial Fusion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Cobalt Ion Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Cell Death Golgi To Vacuole Transport Negative Regulation Of ATPase Activity Regulation Of Relaxation Of Muscle Vesicle Fusion With Golgi Apparatus
Tagcloud ?		agonist am80 anionic atra c6 carrier counterpart eaac1 eaat3 encodes glioma hx630 intermediate le540 markedly messenger mimicked mrnas rarb rarbeta rfx1 rodent rxr silencing stimulates trafficking trans transporter unchanged
Tagcloud (Difference) ?		agonist am80 anionic atra c6 carrier counterpart eaac1 eaat3 encodes glioma hx630 intermediate le540 markedly messenger mimicked mrnas rarb rarbeta rfx1 rodent rxr silencing stimulates trafficking trans transporter unchanged
Tagcloud (Intersection) ?