SLC1A1 and RNF5

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SLC1A1	RNF5
Gene Name		solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	ring finger protein 5, E3 ubiquitin protein ligase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	L-glutamate Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Sodium:dicarboxylate Symporter Activity Cysteine Transmembrane Transporter Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Ion Transport Synaptic Transmission Cysteine Transport Protein Homooligomerization L-glutamate Import Transmembrane Transport D-aspartate Import L-glutamate Transmembrane Transport	Response To Bacterium Negative Regulation Of Autophagy Protein Destabilization Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination ER-associated Misfolded Protein Catabolic Process Regulation Of Autophagic Vacuole Assembly
Pathways		Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs		L-Aspartic Acid L-Glutamic Acid
Diseases
GWAS		Pancreatic cancer ( 22158540)	Prostate cancer ( 23535732)
Protein-Protein Interactions		6 interactors: APP ARL6IP5 EWSR1 LDLRAD1 PRKCA RNF5	32 interactors: ABHD16A CFTR CYB561 CYB561A3 FHOD1 INSIG2 JKAMP MAVS MPDZ PXN RNF185 SEC22A SLC1A1 SLC38A7 TGFBR1 TMEM242 TNFAIP3 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2K UBE2N UBE2U UBE2V1 UBE2W UBE2Z YIPF2
Entrez ID		6505	6048
HPRD ID		00597	04057
Ensembl ID		ENSG00000106688	ENSG00000204308
Uniprot IDs		P43005	Q99942
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Histone H3-T6 Phosphorylation Collateral Sprouting In Absence Of Injury ER-associated Misfolded Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Apoptotic Process Platelet Activation Programmed Cell Death Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Hydrolase Activity Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Peptidyl-serine Autophosphorylation Axon Choice Point Recognition Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cell Cycle Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Regulation Of Phosphorylation Calcium Ion Homeostasis Neuron Remodeling Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Response To Light Stimulus Response To Stress Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Negative Regulation Of Glucose Import Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Macrophage Differentiation Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Desmosome Organization Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Membrane Potential Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Misfolded Or Incompletely Synthesized Protein Catabolic Process	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Activation Of Innate Immune Response Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Positive Regulation Of Innate Immune Response Cellular Protein Modification Process Regulation Of Innate Immune Response Cellular Macromolecule Catabolic Process Toll-like Receptor 4 Signaling Pathway Cellular Protein Metabolic Process Cellular Response To Stress Toll-like Receptor Signaling Pathway Proteolysis Immune Response-regulating Signaling Pathway Protein Metabolic Process Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Regulation Of Protein Ubiquitination Catabolic Process Positive Regulation Of Immune Response Histone Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Monoubiquitination Response To Organic Substance Negative Regulation Of Type I Interferon Production ISG15-protein Conjugation Aspartate Transport Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Innate Immune Response Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To Organic Substance TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune Response Cellular Response To Transforming Growth Factor Beta Stimulus MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway
Tagcloud ?		agonist am80 anionic atra c6 carrier counterpart eaac1 eaat3 encodes glioma hx630 intermediate le540 markedly messenger mimicked mrnas rarb rarbeta rfx1 rodent rxr silencing stimulates trafficking trans transporter unchanged	adapt autoadaptive built cleared clients deploys dislocation dislocon dislocons engage erad folding herp hrd1 interrupt ligases machineries misfolded p97 perturbation polyubiquitylation preempt proteasomal proteostasis relay relies tuning turnover ubc6e
Tagcloud (Difference) ?		agonist am80 anionic atra c6 carrier counterpart eaac1 eaat3 encodes glioma hx630 intermediate le540 markedly messenger mimicked mrnas rarb rarbeta rfx1 rodent rxr silencing stimulates trafficking trans transporter unchanged	adapt autoadaptive built cleared clients deploys dislocation dislocon dislocons engage erad folding herp hrd1 interrupt ligases machineries misfolded p97 perturbation polyubiquitylation preempt proteasomal proteostasis relay relies tuning turnover ubc6e
Tagcloud (Intersection) ?