SLC1A1

Gene Name		solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	L-glutamate Transmembrane Transporter Activity Glutamate:sodium Symporter Activity Glutamate Binding Sodium:dicarboxylate Symporter Activity Cysteine Transmembrane Transporter Activity
	Biological Process	Ion Transport Synaptic Transmission Cysteine Transport Protein Homooligomerization L-glutamate Import Transmembrane Transport D-aspartate Import L-glutamate Transmembrane Transport
Pathways		Neurotransmitter Release Cycle Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs		L-Aspartic Acid L-Glutamic Acid
Diseases
GWAS		Pancreatic cancer ( 22158540)
Protein-protein Interactions		6 interactors: APP ARL6IP5 EWSR1 LDLRAD1 PRKCA RNF5
Entrez ID		6505
HPRD ID		00597
Ensembl ID		ENSG00000106688
Uniprot IDs		P43005
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Histone H3-T6 Phosphorylation Collateral Sprouting In Absence Of Injury ER-associated Misfolded Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway Apoptotic Process Platelet Activation Programmed Cell Death Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Hydrolase Activity Cell Death Death Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Mitochondrial Membrane Potential Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Peptidyl-serine Autophosphorylation Axon Choice Point Recognition Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cell Cycle Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Regulation Of Phosphorylation Calcium Ion Homeostasis Neuron Remodeling Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Response To Light Stimulus Response To Stress Apoptotic Signaling Pathway Regulation Of Phosphorus Metabolic Process Negative Regulation Of Glucose Import Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Macrophage Differentiation Positive Regulation Of Catalytic Activity Regulation Of Endopeptidase Activity Desmosome Organization Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Membrane Potential Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Regulation Of Mitotic Cell Cycle Misfolded Or Incompletely Synthesized Protein Catabolic Process
Tagcloud ?		agonist am80 anionic atra c6 carrier counterpart eaac1 eaat3 encodes glioma hx630 intermediate le540 markedly messenger mimicked mrnas rarb rarbeta rfx1 rodent rxr silencing stimulates trafficking trans transporter unchanged