TNFRSF13B

Description		TNF receptor superfamily member 13B
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GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Protein Binding Signaling Receptor Activity
	Biological Process	B Cell Homeostasis Hematopoietic Progenitor Cell Differentiation Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Diabetic retinopathy ( 21441570) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hematological and biochemical traits ( 20139978) Hematology traits ( 23303382) IgG levels ( 22673310) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple myeloma ( 32569378 33875642 23955597 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 22558069 29403010) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Serum albumin levels ( 29403010) Serum total protein levels ( 23022100 29403010) Sodium levels ( 29403010) Systemic lupus erythematosus ( 33272962) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494)
Novel Interacting Genes		1 novel interacting genes: B9D1
Interacting Genes		7 interacting genes: CAMLG SGTA TNFSF13 TNFSF13B TRAF2 TRAF5 TRAF6
Entrez ID		23495
HPRD ID		05365
Ensembl ID		ENSG00000240505
Uniprot IDs		O14836 Q4ACX1
PDB IDs		1XU1 1XUT
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding CD40 Receptor Complex CD40 Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Lymphocyte Homeostasis Leukocyte Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Regulation Of Immunoglobulin Production Thioesterase Binding Positive Regulation Of JUN Kinase Activity Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Cytokine-mediated Signaling Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Multicellular Organismal-level Homeostasis Positive Regulation Of Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Homeostasis Of Number Of Cells B Cell Homeostasis Protein Insertion Into ER Membrane Positive Regulation Of T Cell Cytokine Production Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Lymphocyte Mediated Immunity Non-canonical NF-kappaB Signal Transduction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Interleukin-2 Production Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Immune Response Regulation Of T Cell Cytokine Production Regulation Of Mononuclear Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Immune Effector Process Regulation Of Leukocyte Proliferation Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Signal Transduction
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