TNFRSF13B and TRAF5

Number of citations of the paper that reports this interaction (PMID 10880535)
45

Data Source:
HPRD (in vitro, in vivo)

		TNFRSF13B	TRAF5
Gene Name		tumor necrosis factor receptor superfamily, member 13B	TNF receptor-associated factor 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane External Side Of Plasma Membrane	Cytoplasm Centrosome Cytosol Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex
	Molecular Function	Receptor Activity Protein Binding	Ubiquitin-protein Transferase Activity Signal Transducer Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Thioesterase Binding
	Biological Process	B Cell Homeostasis Hematopoietic Progenitor Cell Differentiation Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation	Apoptotic Process Signal Transduction Positive Regulation Of Cell Proliferation Protein Ubiquitination Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways
Drugs
Diseases
GWAS		Diabetic retinopathy ( 21441570) Hematological and biochemical traits ( 20139978) Hematology traits ( 23303382) IgG levels ( 22673310) Non-albumin protein levels ( 22558069) Serum total protein level ( 23022100)
Protein-Protein Interactions		7 interactors: CAMLG SGTA TNFSF13 TNFSF13B TRAF2 TRAF5 TRAF6	42 interactors: CAPNS1 CCDC184 CD27 CD40 COG7 COMMD3 DGKH ENOX2 GORASP2 LTBR MAP3K14 MAP3K5 MAVS MDM2 NGFRAP1 NMI NUMBL RAD23A RIPK1 RIPK2 RNF111 SDCBP SEC13 SERPINB9 TDP2 THAP1 TNFRSF11A TNFRSF12A TNFRSF13B TNFRSF14 TNFRSF19 TNFRSF4 TNFRSF8 TRAF2 TRAF3 TRAF3IP2 TRAF6 TRIM27 TRIM37 TRIM8 USP7 ZFAND6
Entrez ID		23495	7188
HPRD ID		05365	03834
Ensembl ID		ENSG00000240505	ENSG00000082512
Uniprot IDs		B7Z6V8 O14836 Q4ACX1	D3DT93 O00463
PDB IDs		1XU1 1XUT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Adaptive Immune Response Regulation Of Adaptive Immune Response Positive Regulation Of Germinal Center Formation Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cell Activation Regulation Of Immunoglobulin Secretion Regulation Of Germinal Center Formation Positive Regulation Of T Cell Cytokine Production Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Regulation Of T Cell Cytokine Production Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cell-cell Adhesion Protein K63-linked Ubiquitination Positive Regulation Of Interleukin-2 Production Positive Regulation Of Cell Proliferation NIK/NF-kappaB Signaling Regulation Of NIK/NF-kappaB Signaling Regulation Of Immune Response Protein Autoubiquitination Regulation Of T Cell Activation Positive Regulation Of Immune System Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cytokine Production Involved In Immune Response I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immunoglobulin Production TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of B Cell Activation Toll-like Receptor 4 Signaling Pathway Regulation Of JUN Kinase Activity Positive Regulation Of T Cell Proliferation Immune Response Regulation Of Immune System Process Positive Regulation Of T Cell Mediated Immunity Toll-like Receptor Signaling Pathway Regulation Of Cell Proliferation Protein Ubiquitination Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation	Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Cell Death Death Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of JNK Cascade Cellular Response To Stimulus Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune System Process Regulation Of Protein Metabolic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Signal Transduction Regulation Of JNK Cascade Immune Response Signal Transduction Apoptotic Process Regulation Of Stress-activated MAPK Cascade Response To Tumor Necrosis Factor Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Signaling Positive Regulation Of MAPK Cascade Cell Communication Cellular Response To Organic Substance Regulation Of Apoptotic Process Response To Stimulus Positive Regulation Of Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cytokine Production Response To Cytokine Regulation Of Phosphorylation Regulation Of Cell Death Cellular Response To Cytokine Stimulus Positive Regulation Of MAP Kinase Activity Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Response To Organic Substance Regulation Of Immunoglobulin Secretion Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Regulation Of Lymphocyte Activation Defense Response Positive Regulation Of Protein Serine/threonine Kinase Activity
Tagcloud ?		adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase plcg1 rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold traf2	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf2 traf3 traf6 transduction
Tagcloud (Difference) ?		adjusting associations card11 clear consortium correcting determinants endometrioid eoc highlight histologies histology immunity inherited member modulating mucinous note phospholipase plcg1 rs11696662 rs17250239 rs41324349 rs7501462 serous superfamily threshold	adhesion affinity bind cd40 cd40ct cytoplasmic dispensable dominantly extensive icam ikappabalpha implicated incapable intercellular jak3 kappab mediators molecule much mutants necrosis residues strongly tail traf3 traf6 transduction
Tagcloud (Intersection) ?		traf2