TNFRSF13B and TNFSF13B

Number of citations of the paper that reports this interaction (PubMedID 10801128)
0

Data Source:
HPRD (in vitro, in vivo)

		TNFRSF13B	TNFSF13B
Description		TNF receptor superfamily member 13B	TNF superfamily member 13b
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Focal Adhesion Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Signaling Receptor Activity	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	B Cell Homeostasis Hematopoietic Progenitor Cell Differentiation Adaptive Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation	B Cell Homeostasis Lymphocyte Homeostasis Transitional One Stage B Cell Differentiation Immune System Process Germinal Center Formation Positive Regulation Of Germinal Center Formation Immune Response Cell Communication Signal Transduction Signaling B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation B Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation B Cell Proliferation Positive Regulation Of T Cell Proliferation Skin Development Regulation Of Immune Response
Pathways		TNFs bind their physiological receptors	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs			1,4-Dioxane Belimumab
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Diabetic retinopathy ( 21441570) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hematological and biochemical traits ( 20139978) Hematology traits ( 23303382) IgG levels ( 22673310) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Multiple myeloma ( 32569378 33875642 23955597 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 22558069 29403010) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Serum albumin levels ( 29403010) Serum total protein levels ( 23022100 29403010) Sodium levels ( 29403010) Systemic lupus erythematosus ( 33272962) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Femur bone mineral density x serum urate levels interaction ( 34046847) HDL cholesterol levels ( 32203549) IgG levels ( 28628107) Metabolite levels ( 23823483) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Non-albumin protein levels ( 29403010) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Spleen volume ( 34128465) Tonsillectomy ( 28928442 27182965) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) White blood cell count ( 27863252)
Interacting Genes		7 interacting genes: CAMLG SGTA TNFSF13 TNFSF13B TRAF2 TRAF5 TRAF6	5 interacting genes: APP TNFRSF13B TNFRSF13C TNFRSF17 TNFSF13
Entrez ID		23495	10673
HPRD ID		05365	04914
Ensembl ID		ENSG00000240505	ENSG00000102524
Uniprot IDs		O14836 Q4ACX1	A0A0U5J7Q1 Q9Y275
PDB IDs		1XU1 1XUT	1JH5 1KD7 1KXG 1OQD 1OQE 1OSG 3V56 4V46 4ZCH 5Y9J 6FXN
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding CD40 Receptor Complex CD40 Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Adaptive Immune Response Lymphocyte Homeostasis Leukocyte Homeostasis Positive Regulation Of NF-kappaB Transcription Factor Activity Signaling Adaptor Activity Regulation Of Immunoglobulin Production Thioesterase Binding Positive Regulation Of JUN Kinase Activity Cytoplasmic Side Of Plasma Membrane Negative Regulation Of Catabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Cytokine-mediated Signaling Pathway Tail-anchored Membrane Protein Insertion Into ER Membrane Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Multicellular Organismal-level Homeostasis Positive Regulation Of Leukocyte Proliferation Cell Surface Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Homeostasis Of Number Of Cells B Cell Homeostasis Protein Insertion Into ER Membrane Positive Regulation Of T Cell Cytokine Production Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Lymphocyte Mediated Immunity Non-canonical NF-kappaB Signal Transduction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Interleukin-2 Production Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Immune Response Regulation Of T Cell Cytokine Production Regulation Of Mononuclear Cell Proliferation Positive Regulation Of B Cell Proliferation Positive Regulation Of Immune Effector Process Regulation Of Leukocyte Proliferation Ubiquitin Protein Ligase Binding Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Signal Transduction	Lymphocyte Homeostasis Regulation Of B Cell Proliferation Leukocyte Homeostasis Immune Response Regulation Of B Cell Activation Regulation Of Cell Activation Homeostasis Of Number Of Cells Immune System Process Regulation Of Mononuclear Cell Proliferation Signaling Receptor Activity Regulation Of Leukocyte Proliferation Adaptive Immune Response Positive Regulation Of B Cell Proliferation Positive Regulation Of Cell Activation Tumor Necrosis Factor-mediated Signaling Pathway Homeostatic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Multicellular Organismal-level Homeostasis Regulation Of Lymphocyte Activation Positive Regulation Of B Cell Activation Regulation Of Immune System Process Regulation Of Cell Population Proliferation Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cell Surface Receptor Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation B Cell Costimulation Signal Transduction Positive Regulation Of Leukocyte Proliferation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?