SFTPC and WWP2

Number of citations of the paper that reports this interaction (PMID 19366705)
5

Data Source:
BioGRID (pull down)

		SFTPC	WWP2
Gene Name		surfactant protein C	WW domain containing E3 ubiquitin protein ligase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Multivesicular Body Alveolar Lamellar Body	Ubiquitin Ligase Complex Nucleus Cytoplasm Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein Homodimerization Activity	RNA Polymerase II Transcription Factor Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Ligase Activity
	Biological Process	Respiratory Gaseous Exchange Circadian Rhythm Response To Glucose Response To Lipopolysaccharide Response To Retinoic Acid Response To Vitamin A Protein Homooligomerization Response To Glucocorticoid Response To CAMP Response To Hyperoxia Response To Interleukin-6 Response To Growth Factor Cellular Response To Mechanical Stimulus Cellular Response To Nitric Oxide	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Transporter Activity Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell Negative Regulation Of Protein Transport Protein Autoubiquitination Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transporter Activity
Pathways
Drugs
Diseases
GWAS		Hypertriglyceridemia ( 23505323)	IgE levels ( 23146381)
Protein-Protein Interactions		9 interactors: CXCL9 NEDD4 PQBP1 SEC22A SEC61G SYNE4 TMEM79 WWP1 WWP2	53 interactors: ANKRD44 ARRDC1 ATN1 CDC34 CLCN5 CPSF6 DAG1 DIDO1 EGR2 EWSR1 FAM189A2 FBXL18 HNRNPUL1 IL2RG IL6R LGALS9B NDFIP2 PAIP1 PDLIM7 POLR2A POU5F1 RASA1 RNF11 RUSC1 SCAMP3 SCN5A SCNN1A SCNN1B SCNN1G SF1 SFTPC SMAD3 SMAD7 SNRPC SPG20 TFAP2A TNK2 TP53BP2 TRAF4 UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2J2 UBE2K UBE2L3 USP7 VASP VPS37C WBP1 WBP2 WIPF1
Entrez ID		6440	11060
HPRD ID		01520	03812
Ensembl ID		ENSG00000168484	ENSG00000198373
Uniprot IDs		P11686	B4DHF6 O00308
PDB IDs		2YAD
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Interaction With Host Regulation Of Potassium Ion Transmembrane Transporter Activity Protein K63-linked Ubiquitination Regulation Of Potassium Ion Transmembrane Transport Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Potassium Ion Transport Regulation Of Dendrite Morphogenesis Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Regulation Of Dendrite Development Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Locomotion Viral Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cuticle Development Protein Modification By Small Protein Conjugation Protein Catabolic Process Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Ion Transport Cornification Protein Polyubiquitination Cytoplasmic Transport Establishment Of Epithelial Cell Apical/basal Polarity Progesterone Receptor Signaling Pathway Viral Life Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Glucocorticoid Receptor Signaling Pathway Vesicle Fusion With Golgi Apparatus Cellular Macromolecule Catabolic Process Positive Regulation Of Intracellular Transport T Cell Chemotaxis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Establishment Of Monopolar Cell Polarity Proteasomal Protein Catabolic Process Establishment Of Localization In Cell Protein Targeting To Lysosome Regulation Of Membrane Potential Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of CAMP-mediated Signaling Alternative MRNA Splicing, Via Spliceosome	Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Stimulus Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Proteasomal Protein Catabolic Process Transcription Initiation From RNA Polymerase II Promoter Excretion Response To Organic Substance DNA-templated Transcription, Initiation Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Protein K11-linked Ubiquitination Sodium Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Gene Expression Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Response To Stimulus Positive Regulation Of Ossification Regulation Of Ossification RNA Biosynthetic Process Regulation Of Protein Ubiquitination Apoptotic Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Cellular Protein Metabolic Process Viral Process Apoptotic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Protein Catabolic Process RNA Processing Multicellular Organismal Water Homeostasis Programmed Cell Death Negative Regulation Of Transcription By Competitive Promoter Binding Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		activating adenocarcinomas alveolar cdkn2a conditional deaths devastating embryogenesis epithelium foxm1 g12d ikbkb jnk jnk1 jun k kras lung myc nfkb1 nfkb2 oncogene pttg1 ras rela respiratory stimulates sufficient transgenic	accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination
Tagcloud (Difference) ?		activating adenocarcinomas alveolar cdkn2a conditional deaths devastating embryogenesis epithelium foxm1 g12d ikbkb jnk jnk1 jun k kras lung myc nfkb1 nfkb2 oncogene pttg1 ras rela respiratory stimulates sufficient transgenic	accelerating anticancer biomarker cascade catalyzes contributes counterparts deleted dramatic e3 encodes final homologue ligase ligases malignancies member nedd4 neoplastic oscc osccs pi3k promotion pten ten tensin tumoral ubiquitination
Tagcloud (Intersection) ?