SFTPC and HPN

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		SFTPC	HPN
Name		surfactant protein C	hepsin
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen	Endoplasmic Reticulum Membrane Plasma Membrane Cell-cell Junction Cell Surface Membrane Apical Plasma Membrane Nuclear Membrane Neuronal Cell Body Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Serine-type Exopeptidase Activity
	Biological Process	Respiratory Gaseous Exchange By Respiratory System	Proteolysis Regulation Of Cell Shape Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Plasminogen Activation Protein Processing Positive Regulation Of Cell Growth Basement Membrane Disassembly Negative Regulation Of Apoptotic Process Host-mediated Activation Of Viral Transcription Negative Regulation Of Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Regulation Of Biological Quality Potassium Ion Transmembrane Transport Cochlea Morphogenesis Response To Thyroid Hormone Pilomotor Reflex Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Thyroid Hormone Generation
Pathways		Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	MET Receptor Activation Signaling by MST1
Drugs		None	Bentiromide Benzylsulfonic acid CRA_1144 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine
Diseases		Pulmonary surfactant metabolism dysfunction (SMDP)	None
GWAS		Coronary artery disease ( 29212778 ) Hypertriglyceridemia ( 23505323 )	Appendicular lean mass ( 33097823 ) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Platelet count ( 32888494 ) Plateletcrit ( 32888494 ) Serum albumin levels ( 23022100 ) Serum total protein levels ( 29403010 ) Triglyceride levels ( 32154731 32203549 ) Urinary albumin-to-creatinine ratio ( 31511532 ) Urinary albumin-to-creatinine ratio in diabetes ( 31511532 )
Novel Interactors		None recorded	2 novel interactors: BRIP1 MEGF8
Interacting Genes		35 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2	7 interacting genes: BNIP3 EGFR F7 GLP1R HGF SFTPC UPK2
Entrez ID		6440	3249
HPRD ID		01520	00801
Ensembl ID		ENSG00000168484	ENSG00000105707
Uniprot IDs		A0A0S2Z4Q0 E5RI64 P11686	A0A140VJK9 B7Z1L4 P05981
PDB IDs		2YAD 8OVI 8OX2	1O5E 1O5F 1P57 1Z8G 3T2N 5CE1
GO Terms Enriched among Interactors		Membrane Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Cobalt Ion Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Regulation Of Mitochondrion Organization Endoplasmic Reticulum-autophagosome Adaptor Activity Regulation Of Release Of Cytochrome C From Mitochondria Autophagic Cell Death Substrate Localization To Autophagosome Negative Regulation Of Mitochondrial Fusion Positive Regulation Of Mitochondrial Calcium Ion Concentration Developmental Process Mitochondrion Autophagosome Adaptor Activity Positive Regulation Of Cell Growth Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Locomotion Epiboly Involved In Gastrulation With Mouth Forming Second Embryonic Heart Tube Left/right Pattern Formation Positive Regulation Of Axon Extension Involved In Axon Guidance Determination Of Heart Left/right Asymmetry Regulation Of Locomotion Determination Of Digestive Tract Left/right Asymmetry Positive Regulation Of Chemotaxis Embryonic Organ Development Fasciculation Of Sensory Neuron Axon Animal Organ Development Regulation Of Protein Kinase C Signaling Epithelial Cell Proliferation Response To Amino Acid Response To Estradiol Positive Regulation Of Cell Migration Epidermal Growth Factor Binding Positive Regulation Of Cell Motility ERBB2-EGFR Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Shc-EGFR Complex Cell Morphogenesis Multivesicular Body, Internal Vesicle Lumen Response To Thyroxine Response To Genistein Response To Vitamin K Endopeptidase Activity Response To Hydroxyisoflavone Response To Astaxanthin Response To Phenylpropanoid Serine-type Peptidase Complex Response To Carbon Dioxide Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Response To L-phenylalanine Derivative Response To Thyroid Stimulating Hormone