SFTPC and TMEM30B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SFTPC	TMEM30B
Description		surfactant protein C	transmembrane protein 30B
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Phospholipid-translocating ATPase Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Aminophospholipid Flippase Activity
	Biological Process	Respiratory Gaseous Exchange By Respiratory System	Lipid Transport Aminophospholipid Transport Phospholipid Translocation Positive Regulation Of Protein Exit From Endoplasmic Reticulum Aminophospholipid Translocation
Pathways		Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4
Drugs
Diseases		Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)	Nickel levels ( 26025379) Obesity-related traits ( 23251661) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		35 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2	4 interacting genes: GPR42 PMP22 SCD SFTPC
Entrez ID		6440	161291
HPRD ID		01520	18567
Ensembl ID		ENSG00000168484	ENSG00000182107
Uniprot IDs		A0A0S2Z4Q0 E5RI64 P11686	Q3MIR4
PDB IDs		2YAD 8OVI 8OX2	7VGH
Enriched GO Terms of Interacting Partners?		Membrane Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Monounsaturated Fatty Acid Biosynthetic Process Palmitoyl-CoA 9-desaturase Activity Compact Myelin Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Stearoyl-CoA 9-desaturase Activity Multivesicular Body Lumen Alveolar Lamellar Body Lamellar Body Bleb Assembly Myelin Assembly Clathrin-coated Endocytic Vesicle
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