SFTPC and CD200R1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SFTPC	CD200R1
Description		surfactant protein C	CD200 receptor 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Immunoglobulin Receptor Activity Signaling Receptor Activity Glycosylated Region Protein Binding
	Biological Process	Respiratory Gaseous Exchange By Respiratory System	Signal Transduction Negative Regulation Of Interleukin-6 Production Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration
Pathways		Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)	Asthma ( 32296059) Blood protein levels ( 30072576) Economic and political preferences ( 22566634) Eosinophil count ( 27863252 32888494) Eosinophil percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neurological blood protein biomarker levels ( 31320639) Rheumatoid arthritis ( 28118524) Rheumatoid arthritis (rheumatoid factor and/or anti-cyclic citrullinated peptide seropositive) ( 28118524) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		35 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2	9 interacting genes: ADIPOQ CD200 CLDN19 ERMP1 GALNT15 NINJ1 PTCH1 SFTPC SGTB
Entrez ID		6440	131450
HPRD ID		01520	09609
Ensembl ID		ENSG00000168484	ENSG00000163606
Uniprot IDs		A0A0S2Z4Q0 E5RI64 P11686	Q8TD46
PDB IDs		2YAD 8OVI 8OX2	9GWT
Enriched GO Terms of Interacting Partners?		Membrane Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Negative Regulation Of Cell Population Proliferation Cell-cell Adhesion Mediator Activity Negative Regulation Of Cell Migration Heterotypic Cell-cell Adhesion Ferroptosis Neural Plate Axis Specification Positive Regulation Of Cholesterol Efflux Regulation Of Cholesterol Transport Regulation Of Cholesterol Efflux Positive Regulation Of Cholesterol Transport Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of Cell Migration Regulation Of Inflammatory Response Response To Chlorate Positive Regulation Of Lipid Transport Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Detection Of Oxidative Stress TRC Complex Mesaxon Regulation Of Cell Motility Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Locomotion Glycosylated Region Protein Binding Hedgehog Family Protein Binding Hedgehog Receptor Activity Response To Linoleic Acid Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cholesterol Import Cell-cell Adhesion Protein Binding Involved In Heterotypic Cell-cell Adhesion Negative Regulation Of Protein Transport Regeneration Membrane Destabilizing Activity Epidermal Cell Fate Specification Smoothened Binding Localization Within Membrane Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Receptor Binding Regulation Of Glycogen (starch) Synthase Activity Regulation Of Transepithelial Transport Negative Regulation Of Establishment Of Protein Localization Regulation Of Lipid Transport Regulation Of Mononuclear Cell Migration Negative Regulation Of Secretion By Cell Regulation Of Cholesterol Import
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