SFTPC and SIGLEC9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SFTPC	SIGLEC9
Description		surfactant protein C	sialic acid binding Ig like lectin 9
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Alveolar Lamellar Body Multivesicular Body Lumen	Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Carbohydrate Binding Sialic Acid Binding
	Biological Process	Respiratory Gaseous Exchange By Respiratory System	Cell Adhesion Cell Surface Receptor Signaling Pathway
Pathways		Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation
Drugs
Diseases		Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)	Body mass index ( 29273807) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252 32888494) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		35 interacting genes: BSCL2 CD200R1 CD79A CLDN5 CPLX4 CREB3 CXCL9 FAM209A FNDC9 GJA8 GOLM1 GPR152 GPX8 HPN ICAM3 IFNGR2 KLRC1 LMNA LSMEM2 MUC1 NEDD4 PDZK1IP1 PQBP1 SEC22A SEC61G SIGLEC9 SMIM3 SYNE4 TMEM106C TMEM139 TMEM30B TMEM79 TMPRSS2 WWP1 WWP2	4 interacting genes: BRICD5 LGALS3BP NCS1 SFTPC
Entrez ID		6440	27180
HPRD ID		01520	16133
Ensembl ID		ENSG00000168484	ENSG00000129450
Uniprot IDs		A0A0S2Z4Q0 E5RI64 P11686	Q9Y336
PDB IDs		2YAD 8OVI 8OX2
Enriched GO Terms of Interacting Partners?		Membrane Negative Regulation Of Potassium Ion Export Across Plasma Membrane	Extracellular Space Lamellar Body Multivesicular Body Lumen Alveolar Lamellar Body Calcium Sensitive Guanylate Cyclase Activator Activity Mitochondrial Intermembrane Space Chaperone Complex
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