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UCHL3 and LONRF1
Number of citations of the paper that reports this interaction (PMID
23105109
)
4
Data Source:
BioGRID
(two hybrid)
UCHL3
LONRF1
Gene Name
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
LON peptidase N-terminal domain and ring finger 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
Ubiquitin-specific Protease Activity
Protein Binding
Peptidase Activity
Ubiquitin Binding
ATP-dependent Peptidase Activity
Zinc Ion Binding
Biological Process
Ubiquitin-dependent Protein Catabolic Process
Protein Catabolic Process
Proteolysis
Pathways
Drugs
Diseases
GWAS
Diabetic retinopathy (
23562823
)
Protein-Protein Interactions
17 interactors:
ATXN7L3
CDH1
HMP19
LONRF1
NEDD8
PJA1
PLA2G2A
POGK
TRIM27
TRIM54
TRIM55
TRIM63
UBC
UBE2S
USP15
USP21
USP28
32 interactors:
ADAMTSL4
ALAS1
ATG9A
BRCA1
BYSL
CALCOCO2
CCDC36
CRX
EFHC2
GORASP1
GORASP2
IKZF2
IQCF2
KAT5
KCTD9
KRT31
KRTAP13-1
LHX4
NR4A1
PLSCR1
RBPMS
SFN
SPRY2
STAU1
STX11
TRIM42
TRIM9
UBE2L6
UCHL3
USP2
WDYHV1
XIAP
Entrez ID
7347
91694
HPRD ID
04367
08674
Ensembl ID
ENSG00000118939
ENSG00000154359
Uniprot IDs
P15374
Q17RB8
PDB IDs
1UCH
1XD3
Enriched GO Terms of Interacting Partners
?
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Catabolic Process
Protein Modification By Small Protein Conjugation
Proteolysis
Histone Deubiquitination
Protein Deubiquitination
Protein Modification By Small Protein Removal
Cellular Protein Modification Process
Protein Ubiquitination
Protein Polyubiquitination
Regulation Of Protein Catabolic Process
Activation Of Anaphase-promoting Complex Activity
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Cellular Protein Metabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Protein Metabolic Process
Regulation Of Proteolysis
Positive Regulation Of Protein Ubiquitination
Protein K11-linked Ubiquitination
Transforming Growth Factor Beta Receptor Signaling Pathway
DNA Damage Checkpoint
Regulation Of Cellular Protein Metabolic Process
Protein K63-linked Ubiquitination
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Transforming Growth Factor Beta
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Protein Ubiquitination
Regulation Of Protein Metabolic Process
Cell Cycle Checkpoint
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cellular Process
Negative Regulation Of Transferase Activity
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Free Ubiquitin Chain Polymerization
Negative Regulation Of Interleukin-2 Secretion
Histone H2B Conserved C-terminal Lysine Deubiquitination
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
DNA Damage Response, Signal Transduction Resulting In Transcription
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity
Modification-dependent Protein Catabolic Process
Positive Regulation Of Protein Acetylation
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Protein Catabolic Process
Apoptotic Process
Negative Regulation Of Cell Death
Programmed Cell Death
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Apoptotic Process
Cell Death
Death
Negative Regulation Of Hydrolase Activity
Androgen Receptor Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Gene Expression
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cell Death
Positive Regulation Of Histone H4-K20 Methylation
Positive Regulation Of Histone H4-K16 Acetylation
Positive Regulation Of Photoreceptor Cell Differentiation
Positive Regulation Of Cellular Metabolic Process
Intracellular Receptor Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity
Innate Immune Response
Negative Regulation Of Cellular Protein Metabolic Process
Synaptic Vesicle Exocytosis
Regulation Of Protein Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Medial Motor Column Neuron Differentiation
Positive Regulation Of Histone H3-K9 Acetylation
Negative Regulation Of SNARE Complex Assembly
Positive Regulation Of Protein Linear Polyubiquitination
Late Nucleophagy
Piecemeal Microautophagy Of Nucleus
Negative Regulation Of Protein Metabolic Process
Response To Stress
Positive Regulation Of Transcription, DNA-templated
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cellular Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Viral Genome Replication
Tagcloud
?
attempts
c2
canine
changed
chemokine
depends
eia3
eia4
epo
folding
gstt3
hours
hsp90
hypothetical
introduced
kit
masitinib
mast
neoplastic
pdia3
pro
proliferative
proteome
selenbp1
steroid
tardbp
transcriptionally
transcriptome
tumour
Tagcloud (Difference)
?
attempts
c2
canine
changed
chemokine
depends
eia3
eia4
epo
folding
gstt3
hours
hsp90
hypothetical
introduced
kit
masitinib
mast
neoplastic
pdia3
pro
proliferative
proteome
selenbp1
steroid
tardbp
transcriptionally
transcriptome
tumour
Tagcloud (Intersection)
?