UCHL3 and ATXN7L3

Number of citations of the paper that reports this interaction (PubMedID 16713569)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UCHL3	ATXN7L3
Description		ubiquitin C-terminal hydrolase L3	ataxin 7 like 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol	SAGA Complex Nucleus Transcription Factor TFTC Complex SAGA-type Complex DUBm Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Ubiquitin Binding Deubiquitinase Activity	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Catabolic Process Post-translational Protein Modification	Regulation Of DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription
Pathways		UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation	HATs acetylate histones
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)	Bipolar disorder ( 31043756) Height ( 31562340)
Interacting Genes		23 interacting genes: ATM ATXN7L3 CCNB1 CDH1 CEBPA FOXM1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5 YAP1	9 interacting genes: APP H2AC20 H2BC21 PICK1 SECISBP2 SERTAD1 UBC UCHL3 USP6
Entrez ID		7347	56970
HPRD ID		04367	12507
Ensembl ID		ENSG00000118939	ENSG00000087152
Uniprot IDs		A0A140VJZ4 P15374	Q14CW9
PDB IDs		1UCH 1XD3 6ISU 6QML 7YV4	2KKT
Enriched GO Terms of Interacting Partners?		Cellular Response To Gamma Radiation Post-translational Protein Modification Response To Gamma Radiation Response To Ionizing Radiation Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Protein K63-linked Ubiquitination Cellular Response To Ionizing Radiation Protein Ubiquitination Response To Stress Cellular Response To Camptothecin Regulation Of Primary Metabolic Process Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Ubiquitin Protein Ligase Activity Cellular Response To Oxygen-containing Compound Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Lithium Ion Nucleoplasm Interleukin-6-mediated Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Lithium Ion Cysteine-type Deubiquitinase Activity Regulation Of DNA Repair Response To Radiation Regulation Of Cell Cycle Phase Transition Regulation Of Metabolic Process Protein Deubiquitination Telomere Maintenance Signal Transduction By P53 Class Mediator Response To Toxic Substance Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Protein-containing Complex Organization Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of DNA Metabolic Process Gland Development Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Deubiquitinase Activity Protein Polyubiquitination Protein Modification By Small Protein Removal DNA Damage Response	Regulation Of Receptor Internalization Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Receptor Internalization Amyloid-beta Complex Growth Cone Lamellipodium Neuron Projection Organization Regulation Of Response To Calcium Ion Amylin Binding Antibacterial Humoral Response Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Receptor-mediated Endocytosis Glial Cell Development Regulation Of Endocytosis Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Trans-Golgi Network Membrane Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Defense Response To Gram-positive Bacterium G Protein-coupled Receptor Binding Protein Heterodimerization Activity Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Endocytic Vesicle Membrane Cysteine-type Deubiquitinase Activity Protein Deubiquitination Protein Modification By Small Protein Removal Nucleosome Structural Constituent Of Chromatin Membrane Curvature Sensor Activity Selenocysteine Insertion Sequence Binding Dephospho-CoA Kinase Activity Intermediate-density Lipoprotein Particle Protein Metabolic Process Axon Midline Choice Point Recognition Recycling Endosome Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding
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