UCHL3 and TRIM55

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		UCHL3	TRIM55
Gene Name		ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)	tripartite motif containing 55
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Extracellular Vesicular Exosome	Nucleus Cytoplasm Microtubule
	Molecular Function	Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Ubiquitin Binding	Signal Transducer Activity Zinc Ion Binding Identical Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process	Signal Transduction
Pathways
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823)	Response to statin therapy ( 22666496)
Protein-Protein Interactions		17 interactors: ATXN7L3 CDH1 HMP19 LONRF1 NEDD8 PJA1 PLA2G2A POGK TRIM27 TRIM54 TRIM55 TRIM63 UBC UBE2S USP15 USP21 USP28	61 interactors: ACTA1 ANKRD1 ATP5B ATXN3 ATXN3L BRAP CKM DCAF6 DES EEF1G EHHADH EIF3E ESPL1 FHL2 FLNA FLNB FLNC GFM1 GMEB1 LMCD1 MDM4 MRPL19 MRPL41 MYBPC1 MYBPC3 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 OTUB1 OTUB2 PCGF1 PIAS1 PIAS2 PIAS3 RNF114 SQSTM1 STAM TCAP TNNI1 TNNI2 TNNI3 TRIM27 TRIM54 TRIM63 TTN UBE2D1 UBE2D2 UBE2D3 UCHL3 UCHL5 USP13 USP28 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		7347	84675
HPRD ID		04367	05927
Ensembl ID		ENSG00000118939	ENSG00000147573
Uniprot IDs		P15374	Q9BYV6
PDB IDs		1UCH 1XD3
Enriched GO Terms of Interacting Partners?		Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Catabolic Process Protein Modification By Small Protein Conjugation Proteolysis Histone Deubiquitination Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Protein Modification Process Protein Ubiquitination Protein Polyubiquitination Regulation Of Protein Catabolic Process Activation Of Anaphase-promoting Complex Activity Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Metabolic Process Regulation Of Proteolysis Positive Regulation Of Protein Ubiquitination Protein K11-linked Ubiquitination Transforming Growth Factor Beta Receptor Signaling Pathway DNA Damage Checkpoint Regulation Of Cellular Protein Metabolic Process Protein K63-linked Ubiquitination Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Metabolic Process Cell Cycle Checkpoint Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cellular Process Negative Regulation Of Transferase Activity Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Free Ubiquitin Chain Polymerization Negative Regulation Of Interleukin-2 Secretion Histone H2B Conserved C-terminal Lysine Deubiquitination Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Actin-myosin Filament Sliding Muscle Filament Sliding Actin-mediated Cell Contraction Protein Deubiquitination Protein Modification By Small Protein Removal Actin Filament-based Movement Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Muscle Contraction Actin Filament-based Process Cellular Protein Catabolic Process Protein Catabolic Process Muscle System Process Protein K48-linked Deubiquitination Cellular Macromolecule Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Striated Muscle Cell Development Cellular Protein Metabolic Process Muscle Structure Development Muscle Cell Development Protein K63-linked Deubiquitination Myofibril Assembly Proteolysis Cellular Protein Modification Process Striated Muscle Tissue Development Cardiac Muscle Tissue Morphogenesis Striated Muscle Cell Differentiation Muscle Tissue Development Muscle Tissue Morphogenesis Actomyosin Structure Organization Muscle Organ Morphogenesis Cardiac Muscle Tissue Development Protein Metabolic Process Muscle Organ Development Protein Modification By Small Protein Conjugation Muscle Cell Differentiation Myosin Filament Assembly Catabolic Process Actin Cytoskeleton Organization Skeletal Muscle Thin Filament Assembly Cytoskeleton Organization Skeletal Myofibril Assembly Response To Muscle Stretch Heart Morphogenesis Striated Muscle Contraction Cellular Process
Tagcloud ?		attempts c2 canine changed chemokine depends eia3 eia4 epo folding gstt3 hours hsp90 hypothetical introduced kit masitinib mast neoplastic pdia3 pro proliferative proteome selenbp1 steroid tardbp transcriptionally transcriptome tumour
Tagcloud (Difference) ?		attempts c2 canine changed chemokine depends eia3 eia4 epo folding gstt3 hours hsp90 hypothetical introduced kit masitinib mast neoplastic pdia3 pro proliferative proteome selenbp1 steroid tardbp transcriptionally transcriptome tumour
Tagcloud (Intersection) ?