SPTBN1 and PLEKHA5

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		SPTBN1	PLEKHA5
Description		spectrin beta, non-erythrocytic 1	pleckstrin homology domain containing A5
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Spectrin Postsynaptic Density Spectrin-associated Cytoskeleton Membrane Cell Junction Axolemma Cortical Cytoskeleton Cortical Actin Cytoskeleton M Band Cuticular Plate Protein-containing Complex Cell Projection Extracellular Exosome Postsynapse Glutamatergic Synapse	Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein-containing Complex Binding Cadherin Binding Actin Filament Binding GTPase Binding	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Mitotic Cytokinesis Plasma Membrane Organization Central Nervous System Development Vesicle-mediated Transport Central Nervous System Formation Actin Cytoskeleton Organization Positive Regulation Of Interleukin-2 Production Golgi To Plasma Membrane Protein Transport Actin Filament Capping Regulation Of SMAD Protein Signal Transduction Membrane Assembly Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane	Reproductive System Development
Pathways		Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	Synthesis of PIPs at the plasma membrane
Drugs		Calcium 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Age-related hearing impairment ( 34108613) Basophil percentage of white cells ( 32888494) Bone mineral density (spine) ( 19079262 18445777 19801982) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chronic kidney disease ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fractures ( 30158200) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 30591961 29785010 29617998 30054594 31959993) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 22504420 29499414) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean platelet volume ( 32888494) Myopia (pathological) ( 22685421) Neutrophil count ( 32888494) Pars triangularis volume ( 31530798) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528) White blood cell count ( 32888494)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)
Interacting Genes		59 interacting genes: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 COPB1 CPNE1 CPNE4 CSNK2A1 CTNNA1 DSCAM DSCR9 DYRK1A EIF3H EPB41 EPB41L3 FTCD GOLGA6L10 GRB2 GRIA2 HSPB1 ITSN1 MAPK14 MEF2C NF2 NOP53 NRIP1 PACSIN1 PCNT PJA1 PKNOX1 PLCB1 PLEKHA5 PRKACA PTEN PYGO1 RINT1 RNF10 SEPTIN8 SH3BP5 SMAD3 SMAD4 SMAD9 SNAPIN SNCA SPTAN1 SREBF2 STAT1 STXBP1 SUMO2 THAP3 TNIK TRAF3IP1 TTC3 YWHAG ZNF251 ZNF512B	30 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX MTCL2 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		6711	54477
HPRD ID		01683	09684
Ensembl ID		ENSG00000115306	ENSG00000052126
Uniprot IDs		B2ZZ89 Q01082	A0A8V8TQ09 A0A8V8TQJ8 A0A9L9PX43 Q9HAU0
PDB IDs		1AA2 1BKR 3EDV	2DKP
Enriched GO Terms of Interacting Partners?		Cytosol Intracellular Signal Transduction Cytoplasm Regulation Of Protein Stability Cytoskeletal Protein Binding Regulation Of Transport Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling SMAD Protein Complex Protein Stabilization Regulation Of Protein Localization Positive Regulation Of Metabolic Process Heteromeric SMAD Protein Complex Glutamatergic Synapse Regulation Of Cellular Component Organization Regulation Of Intracellular Transport Negative Regulation Of Protein Catabolic Process Signal Transduction Negative Regulation Of Cell Cycle Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Cytoskeleton Osteoblast Differentiation Regulation Of Cell Communication Regulation Of Biological Quality Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Intracellular Transport Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Ligand-gated Ion Channel Signaling Pathway Postsynapse Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Vesicle-mediated Transport In Synapse Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport I-SMAD Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Component Organization Cell Junction Organization	Structural Constituent Of Cytoskeleton Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Cytoskeleton Cytoskeleton Organization Double-stranded DNA Helicase Activity Intermediate Filament Organization Intermediate Filament Cadherin Binding Supramolecular Fiber Organization Extracellular Exosome Spectrin Vesicle Cytoskeletal Trafficking Contractile Muscle Fiber Centriole-centriole Cohesion Centriole Cytoskeletal Protein Binding Costamere Structural Molecule Activity Intracellular Protein Localization Ankyrin Binding Cytoskeleton-dependent Intracellular Transport Actin Cytoskeleton Organization Actin Filament Binding Purine Nucleoside Metabolic Process Epithelial Cell Differentiation Microtubule Anchoring Protein Localization To Centrosome Establishment Of Vesicle Localization Actin Filament-based Process Cytosol DATP Biosynthetic Process Adenosine Kinase Activity Membrane Organization Sarcolemma Metanephric Glomerular Basement Membrane Development MLL1 Complex Microtubule Binding Cilium Assembly Vesicle Localization Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Actin Filament Capping Establishment Of Organelle Localization Regulation Of Protein-containing Complex Disassembly
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