SPTBN1 and SH3BP5

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		SPTBN1	SH3BP5
Gene Name		spectrin, beta, non-erythrocytic 1	SH3-domain binding protein 5 (BTK-associated)
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Spectrin Spectrin-associated Cytoskeleton Axolemma M Band Cuticular Plate Protein Complex Extracellular Vesicular Exosome	Cytoplasm Mitochondrion
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein Complex Binding Poly(A) RNA Binding	Protein Kinase Inhibitor Activity Protein Binding SH3 Domain Binding
	Biological Process	Mitotic Cytokinesis Plasma Membrane Organization Common-partner SMAD Protein Phosphorylation SMAD Protein Import Into Nucleus Axon Guidance Golgi To Plasma Membrane Protein Transport Actin Filament Capping Membrane Assembly Protein Targeting To Plasma Membrane	Negative Regulation Of Protein Kinase Activity Signal Transduction Intracellular Signal Transduction
Pathways		Interaction between L1 and Ankyrins Axon guidance Nephrin interactions L1CAM interactions NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Bone mineral density (spine) ( 19079262 19801982 18445777) Myopia (pathological) ( 22685421)	Alcohol and nictotine co-dependence ( 22488850) Alcohol dependence ( 21956439)
Protein-Protein Interactions		39 interactors: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 CPNE1 CPNE4 CSNK2A1 CTNNA1 DISC1 EPB41 EPB41L3 GRB2 GRIA2 MAPK14 MEF2C NF2 PACSIN1 PDE4D PJA1 PLCB1 PLEKHA5 PRKACA PYGO1 RINT1 SH3BP5 SMAD3 SMAD4 SMAD9 SNCA SPTAN1 SREBF2 STAT1 TNIK TRAF3IP1 YWHAG ZNF512B	14 interactors: APP BTK CDC5L DISC1 DST EXOC1 MAPK10 MAPK12 MAPK8 MAPK9 SOS1 SPTBN1 SYNE1 TNKS
Entrez ID		6711	9467
HPRD ID		01683	12030
Ensembl ID		ENSG00000115306	ENSG00000131370
Uniprot IDs		B2ZZ89 Q01082	O60239
PDB IDs		1AA2 1BKR 3EDV	4H3B
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization System Development Intracellular Signal Transduction Nervous System Development Regulation Of Cellular Localization Cell Differentiation Positive Regulation Of Cell Differentiation Regulation Of Cell Differentiation Regulation Of Phosphorylation Regulation Of Signal Transduction Multicellular Organismal Development Anatomical Structure Development Cell-cell Junction Organization Regulation Of Intracellular Transport Developmental Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Protein Phosphorylation Neurogenesis Negative Regulation Of Phosphorylation Apoptotic Process Signaling Anatomical Structure Morphogenesis Negative Regulation Of Cellular Metabolic Process Cell Development Organelle Organization Programmed Cell Death Cell Communication Generation Of Neurons Kidney Development Cell Death Cell Morphogenesis Death Regulation Of Protein Metabolic Process Cell-cell Junction Assembly Epithelium Development Cellular Response To Organonitrogen Compound Renal System Development Cell Activation Organ Development Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Protein Metabolic Process Cell Projection Organization Regulation Of Organelle Organization Positive Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Neuron Development	JUN Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Cell Surface Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Phosphorylation Fc Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Signaling Cell Communication Phosphorylation Intracellular Signal Transduction Positive Regulation Of Innate Immune Response Innate Immune Response Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MAPK Cascade MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Stimulus Signal Transduction By Phosphorylation JNK Cascade Cellular Localization Positive Regulation Of Proteolysis Regulation Of Circadian Rhythm Response To Stress Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Light Stimulus Apoptotic Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Peptidyl-serine Phosphorylation Positive Regulation Of Signal Transduction Immune Response Defense Response Phosphate-containing Compound Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Immune Response
Tagcloud ?		adipocyte analyzing classified cytoskeletal differentially exposed exposure fact fatty insights k18 keratin mediating morphogenesis nicotine obstructive osf3 peroxiredoxin phosphoprotein phosphoproteins phosphoproteomic regeneration semi sixteen smoke sought spectrin spt16 tobacco	activator apollon bioactive bruce context deaths effector familial heterotrimeric hthnr humanin inhibits jaks janus linked london member neuronal occurs precursor sole stat3 transducer unusual upregulated v642i variety via
Tagcloud (Difference) ?		adipocyte analyzing classified cytoskeletal differentially exposed exposure fact fatty insights k18 keratin mediating morphogenesis nicotine obstructive osf3 peroxiredoxin phosphoprotein phosphoproteins phosphoproteomic regeneration semi sixteen smoke sought spectrin spt16 tobacco	activator apollon bioactive bruce context deaths effector familial heterotrimeric hthnr humanin inhibits jaks janus linked london member neuronal occurs precursor sole stat3 transducer unusual upregulated v642i variety via
Tagcloud (Intersection) ?