SPTBN1 and MEF2C

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		SPTBN1	MEF2C
Description		spectrin beta, non-erythrocytic 1	myocyte enhancer factor 2C
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Spectrin Postsynaptic Density Spectrin-associated Cytoskeleton Membrane Cell Junction Axolemma Cortical Cytoskeleton Cortical Actin Cytoskeleton M Band Cuticular Plate Protein-containing Complex Cell Projection Extracellular Exosome Postsynapse Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Sarcoplasm Nuclear Speck Protein-containing Complex Postsynapse
	Molecular Function	RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein-containing Complex Binding Cadherin Binding Actin Filament Binding GTPase Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Minor Groove Of Adenine-thymine-rich DNA Binding DNA-binding Transcription Factor Activity Protein Binding Histone Deacetylase Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cytokinesis Plasma Membrane Organization Central Nervous System Development Vesicle-mediated Transport Central Nervous System Formation Actin Cytoskeleton Organization Positive Regulation Of Interleukin-2 Production Golgi To Plasma Membrane Protein Transport Actin Filament Capping Regulation Of SMAD Protein Signal Transduction Membrane Assembly Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Blood Vessel Development Osteoblast Differentiation Neuron Migration B Cell Homeostasis Heart Looping Endochondral Ossification Blood Vessel Remodeling Chondrocyte Differentiation Germinal Center Formation Regulation Of Germinal Center Formation Response To Ischemia Primary Heart Field Specification Secondary Heart Field Specification Outflow Tract Morphogenesis Sinoatrial Valve Morphogenesis Cardiac Ventricle Formation Regulation Of DNA-templated Transcription Apoptotic Process Humoral Immune Response Nervous System Development Heart Development Muscle Organ Development Skeletal Muscle Tissue Development Muscle Cell Fate Determination Learning Or Memory Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Neural Crest Cell Differentiation Myotube Differentiation Cell Differentiation Neuron Differentiation Platelet Formation Negative Regulation Of Ossification Melanocyte Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of B Cell Proliferation Cellular Response To Trichostatin A B Cell Proliferation Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Megakaryocyte Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurotransmitter Secretion Regulation Of Synaptic Plasticity Positive Regulation Of Skeletal Muscle Tissue Development Neuron Development Cell Morphogenesis Involved In Neuron Differentiation B Cell Receptor Signaling Pathway Smooth Muscle Cell Differentiation Regulation Of Synapse Assembly Regulation Of Synaptic Transmission, Glutamatergic Ventricular Cardiac Muscle Cell Differentiation Regulation Of Synaptic Activity Positive Regulation Of Cardiac Muscle Cell Proliferation Excitatory Postsynaptic Potential Regulation Of Dendritic Spine Development Renal Tubule Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Calcium Ion Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Glomerulus Morphogenesis Nephron Tubule Epithelial Cell Differentiation NMDA Selective Glutamate Receptor Signaling Pathway AMPA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Cardiac Muscle Cell Differentiation Positive Regulation Of Behavioral Fear Response Epithelial Cell Proliferation Involved In Renal Tubule Morphogenesis Positive Regulation Of Skeletal Muscle Cell Differentiation
Pathways		Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	ERK/MAPK targets Transcriptional activation of mitochondrial biogenesis Myogenesis MECP2 regulates transcription factors Heme signaling Cardiogenesis Expression of BMAL (ARNTL), CLOCK, and NPAS2
Drugs		Calcium 1D-myo-inositol 1,4,5-trisphosphate
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Age-related hearing impairment ( 34108613) Basophil percentage of white cells ( 32888494) Bone mineral density (spine) ( 19079262 18445777 19801982) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chronic kidney disease ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fractures ( 30158200) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 30591961 29785010 29617998 30054594 31959993) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 22504420 29499414) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean platelet volume ( 32888494) Myopia (pathological) ( 22685421) Neutrophil count ( 32888494) Pars triangularis volume ( 31530798) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528) White blood cell count ( 32888494)	Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Adult body size ( 32376654) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 24162737) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention deficit hyperactivity disorder ( 29325848) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Body mass index ( 26426971) Bone mineral density ( 23572186 24249740 21533022) Bone mineral density (hip) ( 19801982) Bone mineral density (total hip) ( 29883787) Bone mineral density (Ward's triangle area) ( 27397699) Caffeine consumption from coffee ( 33287642) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Depression ( 29700475) Femoral neck bone mineral density ( 32239398 29499414 22504420) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) General cognitive ability ( 29844566) Glomerular filtration rate in chronic kidney disease ( 26420894) Height ( 20881960 25282103 25429064) Hematocrit ( 32888494) Hemoglobin ( 32888494) Household income (MTAG) ( 31844048) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 27479909) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 27863252 22139419 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Morning person ( 30696823) Multiple sclerosis ( 31604244) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Platelet count ( 32888494 27863252 22139419) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 27863252 32888494) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Retinal arteriolar caliber ( 23776548) Retinal vascular caliber ( 21060863) Rosacea symptom severity ( 29771307) Schizophrenia ( 25056061 30285260) Serum alkaline phosphatase levels ( 33547301) Smoking status (ever vs never smokers) ( 30643258) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Tonometry ( 17903302) Vascular endothelial growth factor levels ( 26910538) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		59 interacting genes: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 COPB1 CPNE1 CPNE4 CSNK2A1 CTNNA1 DSCAM DSCR9 DYRK1A EIF3H EPB41 EPB41L3 FTCD GOLGA6L10 GRB2 GRIA2 HSPB1 ITSN1 MAPK14 MEF2C NF2 NOP53 NRIP1 PACSIN1 PCNT PJA1 PKNOX1 PLCB1 PLEKHA5 PRKACA PTEN PYGO1 RINT1 RNF10 SEPTIN8 SH3BP5 SMAD3 SMAD4 SMAD9 SNAPIN SNCA SPTAN1 SREBF2 STAT1 STXBP1 SUMO2 THAP3 TNIK TRAF3IP1 TTC3 YWHAG ZNF251 ZNF512B	31 interacting genes: ASCL1 CCNB1 CDK1 COPS5 CSNK2A1 EP300 EPAS1 GATA4 HDAC4 HDAC5 HDAC7 HDAC9 KPNA4 MAPK14 MAPK7 MEF2D MYOD1 MYOG NCOA2 NOTCH1 PLA2G12A SMAD2 SOX18 SP1 SPTBN1 TEAD1 TWIST2 UBE2I VGLL2 VGLL4 YWHAZ
Entrez ID		6711	4208
HPRD ID		01683	02809
Ensembl ID		ENSG00000115306	ENSG00000081189
Uniprot IDs		B2ZZ89 Q01082	A0A0D9SFD0 A0A0D9SGI5 A0A0R4J2G5 A0A9L9PYA3 D8L7E9 Q06413
PDB IDs		1AA2 1BKR 3EDV
Enriched GO Terms of Interacting Partners?		Cytosol Intracellular Signal Transduction Cytoplasm Regulation Of Protein Stability Cytoskeletal Protein Binding Regulation Of Transport Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling SMAD Protein Complex Protein Stabilization Regulation Of Protein Localization Positive Regulation Of Metabolic Process Heteromeric SMAD Protein Complex Glutamatergic Synapse Regulation Of Cellular Component Organization Regulation Of Intracellular Transport Negative Regulation Of Protein Catabolic Process Signal Transduction Negative Regulation Of Cell Cycle Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Cytoskeleton Osteoblast Differentiation Regulation Of Cell Communication Regulation Of Biological Quality Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Intracellular Transport Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Ligand-gated Ion Channel Signaling Pathway Postsynapse Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Vesicle-mediated Transport In Synapse Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport I-SMAD Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Component Organization Cell Junction Organization	Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Myotube Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Binding Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Nucleoplasm DNA-binding Transcription Activator Activity Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Fate Commitment Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Nucleus Regulation Of Developmental Process Striated Muscle Tissue Development Protein Lysine Deacetylase Activity Negative Regulation Of Metabolic Process Chromatin Regulation Of Cardiac Muscle Cell Proliferation Muscle Tissue Development Regulation Of Muscle Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Cell Differentiation Histone Deacetylase Activity Heart Development DNA-binding Transcription Factor Activity
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