SPTBN1 and ZNF512B

Number of citations of the paper that reports this interaction (PubMedID 15231748)
54

Data Source:
BioGRID (two hybrid)

		SPTBN1	ZNF512B
Description		spectrin beta, non-erythrocytic 1	zinc finger protein 512B
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Spectrin Postsynaptic Density Spectrin-associated Cytoskeleton Membrane Cell Junction Axolemma Cortical Cytoskeleton Cortical Actin Cytoskeleton M Band Cuticular Plate Protein-containing Complex Cell Projection Extracellular Exosome Postsynapse Glutamatergic Synapse	Nucleus Nucleoplasm
	Molecular Function	RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein-containing Complex Binding Cadherin Binding Actin Filament Binding GTPase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Plasma Membrane Organization Central Nervous System Development Vesicle-mediated Transport Central Nervous System Formation Actin Cytoskeleton Organization Positive Regulation Of Interleukin-2 Production Golgi To Plasma Membrane Protein Transport Actin Filament Capping Regulation Of SMAD Protein Signal Transduction Membrane Assembly Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MiRNA Transcription
Pathways		Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	RHOV GTPase cycle
Drugs		Calcium 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Age-related hearing impairment ( 34108613) Basophil percentage of white cells ( 32888494) Bone mineral density (spine) ( 19079262 18445777 19801982) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chronic kidney disease ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fractures ( 30158200) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 30591961 29785010 29617998 30054594 31959993) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 22504420 29499414) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean platelet volume ( 32888494) Myopia (pathological) ( 22685421) Neutrophil count ( 32888494) Pars triangularis volume ( 31530798) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528) White blood cell count ( 32888494)	Birth weight ( 31043758) Mean platelet volume ( 32888494) Offspring birth weight ( 31043758) Prostate cancer ( 23535732) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		59 interacting genes: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 COPB1 CPNE1 CPNE4 CSNK2A1 CTNNA1 DSCAM DSCR9 DYRK1A EIF3H EPB41 EPB41L3 FTCD GOLGA6L10 GRB2 GRIA2 HSPB1 ITSN1 MAPK14 MEF2C NF2 NOP53 NRIP1 PACSIN1 PCNT PJA1 PKNOX1 PLCB1 PLEKHA5 PRKACA PTEN PYGO1 RINT1 RNF10 SEPTIN8 SH3BP5 SMAD3 SMAD4 SMAD9 SNAPIN SNCA SPTAN1 SREBF2 STAT1 STXBP1 SUMO2 THAP3 TNIK TRAF3IP1 TTC3 YWHAG ZNF251 ZNF512B	72 interacting genes: AJUBA ANKLE2 ANKRD28 AP1G1 APLP2 ATRX BANP BRD1 BTBD2 C11orf68 CDC123 CREBZF CTBP2 DCTN1 DDX3X DROSHA DVL3 EHMT2 FHL3 GLRX3 GOLGA2 HEYL HTATSF1 IL36RN INVS KDM2A KDM3B KLF10 KMT2B L1TD1 LAMB2 LZTS2 MBD1 MDFI MEOX2 MTUS2 MYH10 NACC1 NIBAN2 OS9 PAPPA2 PBRM1 PDE4DIP PEG10 PIAS4 PLCG2 PPP1R15A PTPRF RABEP1 RPS27A RSPH1 SDF4 SIAH1 SMAD1 SPTBN1 SUPT5H TGM2 TNKS2 TOM1 TOX4 TRAF1 TRAF4 VHL VPS35 VPS41 VWF XPC XRCC6 YES1 ZMYM2 ZNF143 ZYX
Entrez ID		6711	57473
HPRD ID		01683	13840
Ensembl ID		ENSG00000115306	ENSG00000196700
Uniprot IDs		B2ZZ89 Q01082	Q96KM6
PDB IDs		1AA2 1BKR 3EDV	2GQJ 8TX8
Enriched GO Terms of Interacting Partners?		Cytosol Intracellular Signal Transduction Cytoplasm Regulation Of Protein Stability Cytoskeletal Protein Binding Regulation Of Transport Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling SMAD Protein Complex Protein Stabilization Regulation Of Protein Localization Positive Regulation Of Metabolic Process Heteromeric SMAD Protein Complex Glutamatergic Synapse Regulation Of Cellular Component Organization Regulation Of Intracellular Transport Negative Regulation Of Protein Catabolic Process Signal Transduction Negative Regulation Of Cell Cycle Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Cytoskeleton Osteoblast Differentiation Regulation Of Cell Communication Regulation Of Biological Quality Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Intracellular Transport Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Ligand-gated Ion Channel Signaling Pathway Postsynapse Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Vesicle-mediated Transport In Synapse Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport I-SMAD Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Component Organization Cell Junction Organization	Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Wnt Signaling Pathway Chromosome Unmethylated CpG Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Cytoplasm Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Protein Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process DNA Binding Zinc Ion Binding Negative Regulation Of Biosynthetic Process Metal Ion Binding Chromatin Remodeling Regulation Of Protein-containing Complex Assembly Positive Regulation Of Microtubule Nucleation Chromatin DEAD/H-box RNA Helicase Binding Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Primary MiRNA Binding Protein Phosphatase Regulator Activity Regulation Of Translation In Response To Endoplasmic Reticulum Stress Cellular Response To Cocaine Thioesterase Binding Protein Localization To Chromosome, Telomeric Region Regulation Of Cellular Component Organization Primary MiRNA Processing
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