USP51 and H2BC3

Number of citations of the paper that reports this interaction (PubMedID 30192049)
0

Data Source:
BioGRID (enzymatic study)

		USP51	H2BC3
Description		ubiquitin specific peptidase 51	H2B clustered histone 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome	Chromosome, Telomeric Region Nucleosome Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Chromatin Binding Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2A Deubiquitinase Activity	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	DNA Repair Proteolysis DNA Damage Response Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Deubiquitination DNA Repair-dependent Chromatin Remodeling Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Nucleosome Assembly
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Educational attainment (years of education) ( 30038396) Mean corpuscular volume ( 29403010) Smoking initiation ( 24665060)
Interacting Genes		11 interacting genes: CDK4 CDK6 DGCR8 ELOC H2AC20 H2AC4 H2BC3 PJA1 USP15 USP21 USP28	49 interacting genes: AKT1 ANAPC11 APP BAP1 BARD1 BMI1 BRCA1 CDC20 CDK1 CDK2 CHD4 CREBBP DNMT1 DYRK1A EID1 EP300 ERCC6 FANCD2 HUWE1 KAT2A KAT2B KMT2A KMT2C KMT2D MYB PALB2 PIAS1 PSMD4 PTPN6 RHBDD2 RNF168 RNF2 RNF20 RNF40 RNF8 RPS6KA5 SMYD5 TSPYL5 UBE2A UBR7 UHRF1 USP16 USP2 USP21 USP22 USP36 USP43 USP51 USP7
Entrez ID		158880	3018
HPRD ID		07167	07536
Ensembl ID		ENSG00000247746	ENSG00000276410
Uniprot IDs		Q70EK9	P33778
PDB IDs			3X1S 3X1U 9C62 9FGQ
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Structural Constituent Of Chromatin Cysteine-type Deubiquitinase Activity Protein Deubiquitination Nucleosome Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Chromatin Organization Post-translational Protein Modification Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Deubiquitinase Activity Cyclin Binding Nucleus Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Epigenetic Regulation Of Gene Expression Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Heterodimerization Activity Negative Regulation Of Antifungal Innate Immune Response Microprocessor Complex Positive Regulation Of Pre-miRNA Processing Nuclear Body Regulation Of Fibroblast Proliferation Cyclin D2-CDK4 Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Modification Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Phase Transition Target-directed MiRNA Degradation Elongin Complex Peptidase Activity Protein K27-linked Deubiquitination Protein-RNA Adaptor Activity Cellular Response To Ionomycin Gliogenesis Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Heterochromatin Formation DeNEDDylase Activity	Chromatin Remodeling Chromatin Organization Post-translational Protein Modification Protein Modification Process Nucleoplasm Protein Metabolic Process Macromolecule Metabolic Process Epigenetic Regulation Of Gene Expression Protein Deubiquitination DNA Repair Chromatin Binding Protein Modification By Small Protein Removal DNA Damage Response Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Transferase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Proteolysis Nucleus DNA Metabolic Process Cellular Response To Stress Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Response To Radiation Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation Cysteine-type Deubiquitinase Activity Negative Regulation Of Biosynthetic Process Protein Ubiquitination Transcription Coactivator Activity Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Double-strand Break Repair Regulation Of DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription
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