USP51 and USP21

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		USP51	USP21
Description		ubiquitin specific peptidase 51	ubiquitin specific peptidase 21
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Chromatin Binding Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2A Deubiquitinase Activity	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Metal Ion Binding
	Biological Process	DNA Repair Proteolysis DNA Damage Response Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Deubiquitination DNA Repair-dependent Chromatin Remodeling Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Chromatin Organization Proteolysis Protein Deubiquitination Ribosome Disassembly Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Rescue Of Stalled Ribosome
Pathways			TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS		Educational attainment (years of education) ( 30038396) Mean corpuscular volume ( 29403010) Smoking initiation ( 24665060)
Interacting Genes		11 interacting genes: CDK4 CDK6 DGCR8 ELOC H2AC20 H2AC4 H2BC3 PJA1 USP15 USP21 USP28	65 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXD1 FOXM1 H2AC18 H2BC3 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RIPK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 YY1 ZNF350
Entrez ID		158880	27005
HPRD ID		07167	05291
Ensembl ID		ENSG00000247746	ENSG00000143258
Uniprot IDs		Q70EK9	Q9UK80
PDB IDs			2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Structural Constituent Of Chromatin Cysteine-type Deubiquitinase Activity Protein Deubiquitination Nucleosome Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Chromatin Organization Post-translational Protein Modification Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Deubiquitinase Activity Cyclin Binding Nucleus Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Epigenetic Regulation Of Gene Expression Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Heterodimerization Activity Negative Regulation Of Antifungal Innate Immune Response Microprocessor Complex Positive Regulation Of Pre-miRNA Processing Nuclear Body Regulation Of Fibroblast Proliferation Cyclin D2-CDK4 Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Modification Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Phase Transition Target-directed MiRNA Degradation Elongin Complex Peptidase Activity Protein K27-linked Deubiquitination Protein-RNA Adaptor Activity Cellular Response To Ionomycin Gliogenesis Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Heterochromatin Formation DeNEDDylase Activity	Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification Process Protein Deubiquitination Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Proteolysis Protein Metabolic Process Peptidase Activity Macromolecule Metabolic Process Protein K48-linked Deubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Deubiquitinase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity Ubiquitin Protein Ligase Activity Protein K63-linked Deubiquitination Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Catabolic Process K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Polyubiquitination Hydrolase Activity Ubiquitin Protein Ligase Binding Monoubiquitinated Protein Deubiquitination Regulation Of Cellular Response To Stress Ubiquitin Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process TOR Signaling Response To Stress Nucleoplasm DeNEDDylase Activity DNA Damage Response Zinc Ion Binding Negative Regulation Of TOR Signaling Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction DNA Repair Regulation Of Telomere Maintenance Positive Regulation Of Autophagy Negative Regulation Of Intracellular Signal Transduction
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