USP51

Description		ubiquitin specific peptidase 51
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome
	Molecular Function	Chromatin Binding Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2A Deubiquitinase Activity
	Biological Process	DNA Repair Proteolysis DNA Damage Response Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Deubiquitination DNA Repair-dependent Chromatin Remodeling Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Drugs
Diseases
GWAS		Educational attainment (years of education) ( 30038396) Mean corpuscular volume ( 29403010) Smoking initiation ( 24665060)
Interacting Genes		11 interacting genes: CDK4 CDK6 DGCR8 ELOC H2AC20 H2AC4 H2BC3 PJA1 USP15 USP21 USP28
Entrez ID		158880
HPRD ID		07167
Ensembl ID		ENSG00000247746
Uniprot IDs		Q70EK9
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Structural Constituent Of Chromatin Cysteine-type Deubiquitinase Activity Protein Deubiquitination Nucleosome Protein Modification By Small Protein Removal Cysteine-type Peptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Chromatin Organization Post-translational Protein Modification Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Deubiquitinase Activity Cyclin Binding Nucleus Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm Positive Regulation Of Fibroblast Proliferation Cyclin D2-CDK6 Complex Epigenetic Regulation Of Gene Expression Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Protein Heterodimerization Activity Negative Regulation Of Antifungal Innate Immune Response Microprocessor Complex Positive Regulation Of Pre-miRNA Processing Nuclear Body Regulation Of Fibroblast Proliferation Cyclin D2-CDK4 Complex Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Modification Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Cycle Phase Transition Target-directed MiRNA Degradation Elongin Complex Peptidase Activity Protein K27-linked Deubiquitination Protein-RNA Adaptor Activity Cellular Response To Ionomycin Gliogenesis Negative Regulation Of Monocyte Differentiation Cell Dedifferentiation Heterochromatin Formation DeNEDDylase Activity
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