CASP3 and PDE10A

Number of citations of the paper that reports this interaction (PubMedID 11602184)
0

Data Source:
HPRD (in vitro)

		CASP3	PDE10A
Description		caspase 3	phosphodiesterase 10A
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Death-inducing Signaling Complex Neuronal Cell Body Glutamatergic Synapse	Cytoplasm Cytosol Synapse Glutamatergic Synapse
	Molecular Function	Protease Binding Endopeptidase Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Peptidase Activity Cysteine-type Peptidase Activity Phospholipase A2 Activator Activity Hydrolase Activity Protein-containing Complex Binding	Nucleotide Binding Catalytic Activity Cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Phosphoric Diester Hydrolase Activity Hydrolase Activity CAMP Binding CGMP Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Luteolysis Response To Hypoxia B Cell Homeostasis Negative Regulation Of Cytokine Production Proteolysis Apoptotic Process DNA Damage Response Axonal Fasciculation Heart Development Sensory Perception Of Sound Learning Or Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Response To Xenobiotic Stimulus Response To UV Response To Wounding Response To Glucose Response To Metal Ion Response To X-ray Regulation Of Macroautophagy Protein Processing Hippocampus Development Protein Catabolic Process Neuron Differentiation Keratinocyte Differentiation Erythrocyte Differentiation Platelet Formation Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Response To Tumor Necrosis Factor Response To Nicotine Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Response To Hydrogen Peroxide T Cell Homeostasis Positive Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Cell Fate Commitment Negative Regulation Of Cell Cycle Negative Regulation Of Activated T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Striated Muscle Cell Differentiation Response To Glucocorticoid Neuron Apoptotic Process Protein Maturation Anterior Neural Tube Closure Protein Poly-ADP-ribosylation Pyroptotic Inflammatory Response Leukocyte Apoptotic Process Response To Anesthetic Cellular Response To Staurosporine Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Regulation Of Synaptic Vesicle Cycle Positive Regulation Of Pyroptotic Inflammatory Response Positive Regulation Of Amyloid-beta Formation Epithelial Cell Apoptotic Process	CAMP Catabolic Process Signal Transduction Negative Regulation Of CGMP-mediated Signaling CGMP Catabolic Process Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Apoptosis induced DNA fragmentation Degradation of the extracellular matrix Signaling by Hippo NADE modulates death signalling Stimulation of the cell death response by PAK-2p34 Caspase-mediated cleavage of cytoskeletal proteins Apoptotic cleavage of cell adhesion proteins Caspase activation via Dependence Receptors in the absence of ligand Caspase activation via Dependence Receptors in the absence of ligand Other interleukin signaling Pyroptosis CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage	cGMP effects G alpha (s) signalling events
Drugs		Pamidronic acid Acetylsalicylic acid Minocycline 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid Emricasan Incadronic acid 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide Tributyrin Oleandrin PAC-1 Glycyrrhizic acid	Caffeine Dipyridamole Papaverine 4,5-bis(4-methoxyphenyl)-2-thiophen-2-yl-1H-imidazole 2-({4-[4-(pyridin-4-ylmethyl)-1H-pyrazol-3-yl]phenoxy}methyl)quinoline 2-{[4-(4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy]methyl}quinoline Mardepodect 6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINE PQ-10 Tofisopam Triflusal Trapidil
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Kawasaki disease ( 33106546 33772158)	Age-related nuclear cataracts ( 24951543) Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758) Body mass index ( 28552196) Body size at age 10 ( 32376654) Chronotype ( 30696823) Conduct disorder (symptom count) ( 20585324) Cortisol levels (saliva) ( 28843169) Diastolic blood pressure ( 27841878 28135244) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Heel bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 32902719) Hyperthyroidism ( 30367059) Hypothyroidism ( 30367059 27182965) Inhibitory control ( 29251981) Medication use (thyroid preparations) ( 31015401) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma thyroid-stimulating hormone levels ( 28333968) Platelet count ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 32888494) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Systolic blood pressure ( 27841878) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997 25743335)
Interacting Genes		157 interacting genes: ACIN1 ADD1 AFP AIFM1 AKAP8 AKT1 APAF1 APP AR ARHGDIA ARHGDIB ARNT ATG4D ATN1 BCAP31 BCAR1 BCL2 BECN1 BID BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BLM BMX BRCA1 CAD CASP10 CASP2 CASP4 CASP6 CASP7 CASP8 CASP9 CAST CDC27 CDC42 CDH1 CDK11B CDKN1A CFLAR COPS6 CRYAB CTNNB1 CTTN DBNL DCC DCTN1 DEDD DFFA DSG3 EIF2AK2 EIF2S1 EIF3J EIF4B EIF4G2 FYN GATA1 GLRX GMNN GOLGA3 GORASP1 GRIPAP1 GSN GZMB HCLS1 HIP1 HMGB1 HNRNPU HSPD1 HSPE1 HTT IL16 IL18 KCNIP3 KRT18 LMNB1 LYN MAP4K1 MAPK8 MAPK8IP3 MAPK9 MAPT MCL1 MDC1 MDM2 MDM4 MEF2A MET MLH1 MYL3 NDUFS1 NEDD4 NFE2L2 NMT2 PAK2 PARG PARP1 PDE10A PDE5A PICALM PIP5K1A PKN1 PKN2 PLA2G4A PLA2G4B PPP3CA PRKCQ PRKCZ PRKDC PSEN1 PSEN2 PSIP1 PSME3 PTBP1 PTGES3 PTMA PXN RABEP1 RAC1 RAD51 RASA1 RB1 RFC1 RNF2 ROCK1 SARS2 SLK SNRNP70 SOCS5 SOHLH1 SP1 SPTAN1 SREBF2 SRF SRP72 STAT1 STK24 STK3 STK4 TFAP2A TGM2 THAP11 TNFSF10 TOP1 TRAF1 TRAF3 UBE4B USO1 VAV1 VIM WEE1 XIAP YWHAE YWHAG ZBTB16	3 interacting genes: CASP3 TOP1 WDR3
Entrez ID		836	10846
HPRD ID		02799	17828
Ensembl ID		ENSG00000164305	ENSG00000112541
Uniprot IDs		A8MVM1 P42574	A0A1B1UZQ1 A0A1B1UZR0 Q9Y233
PDB IDs		1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4 7XN4 7XN5 7XN6	2OUN 2OUP 2OUQ 2OUR 2OUS 2OUU 2OUV 2OUY 2WEY 2Y0J 2ZMF 3SN7 3SNI 3SNL 3UI7 3UUO 3WI2 3WS8 3WS9 3WYK 3WYL 3WYM 4AEL 4AJD 4AJF 4AJG 4AJM 4BBX 4DDL 4DFF 4FCB 4FCD 4HEU 4HF4 4LKQ 4LLJ 4LLK 4LLP 4LLX 4LM0 4LM1 4LM2 4LM3 4LM4 4MRW 4MRZ 4MS0 4MSA 4MSC 4MSE 4MSH 4MSN 4MUW 4MVH 4P0N 4P1R 4PHW 4TPM 4TPP 4WN1 4XY2 4YQH 4YS7 4ZO5 5AXP 5AXQ 5B4K 5B4L 5C1W 5C28 5C29 5C2A 5C2E 5C2H 5DH4 5DH5 5EDE 5EDG 5EDH 5EDI 5I2R 5K9R 5SDU 5SDV 5SDW 5SDX 5SDY 5SDZ 5SE0 5SE1 5SE2 5SE3 5SE4 5SE5 5SE6 5SE7 5SE8 5SE9 5SEA 5SEB 5SEC 5SED 5SEE 5SEF 5SEG 5SEH 5SEI 5SEJ 5SEK 5SEL 5SEM 5SEN 5SEO 5SEP 5SEQ 5SER 5SES 5SET 5SEU 5SEV 5SEW 5SEX 5SEY 5SEZ 5SF0 5SF1 5SF2 5SF3 5SF4 5SF5 5SF6 5SF7 5SF8 5SF9 5SFA 5SFB 5SFC 5SFD 5SFE 5SFF 5SFG 5SFH 5SFI 5SFJ 5SFK 5SFL 5SFM 5SFN 5SFO 5SFP 5SFQ 5SFR 5SFS 5SFT 5SFU 5SFV 5SFW 5SFX 5SFY 5SFZ 5SG0 5SG1 5SG2 5SG3 5SG4 5SG5 5SG6 5SG7 5SG8 5SG9 5SGB 5SGC 5SGD 5SGE 5SGF 5SGG 5SGH 5SGI 5SGJ 5SGK 5SGL 5SGM 5SGN 5SGO 5SGP 5SGQ 5SGR 5SGS 5SGT 5SGU 5SGV 5SGW 5SGX 5SGY 5SGZ 5SH0 5SH1 5SH2 5SH3 5SH4 5SH5 5SH6 5SH7 5SH8 5SH9 5SHA 5SHB 5SHC 5SHD 5SHE 5SHF 5SHG 5SHH 5SHI 5SHJ 5SHK 5SHL 5SHM 5SHN 5SHO 5SHP 5SHQ 5SHR 5SHS 5SHT 5SHU 5SHV 5SHW 5SHX 5SHY 5SHZ 5SI0 5SI1 5SI2 5SI3 5SI4 5SI5 5SI6 5SI7 5SI8 5SI9 5SIA 5SIB 5SID 5SIE 5SIF 5SIG 5SIH 5SII 5SIJ 5SIK 5SIL 5SIM 5SIN 5SIO 5SIP 5SIQ 5SIR 5SIS 5SIT 5SIU 5SIV 5SIW 5SIX 5SIY 5SIZ 5SJ0 5SJ1 5SJ2 5SJ3 5SJ4 5SJ5 5SJ6 5SJ7 5SJ8 5SJ9 5SJA 5SJB 5SJC 5SJD 5SJE 5SJF 5SJG 5SJH 5SJI 5SJJ 5SJK 5SJL 5SJM 5SJN 5SJO 5SJP 5SJQ 5SJR 5SJS 5SJT 5SJU 5SJV 5SJW 5SJX 5SJY 5SJZ 5SK0 5SK1 5SK2 5SK3 5SK4 5SK5 5SK6 5SK7 5SK8 5SK9 5SKA 5SKB 5SKC 5SKD 5SKE 5SKF 5SKG 5SKH 5SKI 5SKJ 5SKK 5SKL 5SKM 5SKN 5SKO 5SKP 5SKQ 5SKR 5SKS 5SKT 5SKU 5SKV 5UWF 5XUI 5XUJ 5ZNL 6IJH 6IJI 6KDX 6KDZ 6KE0 6KO0 6KO1 6KZE 6MSA 6MSC 7BPI 7QPF 7QPM 7QPQ 7QPV 7QQ4 8DI4 8XV3 9JA8
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cell Death Programmed Cell Death Apoptotic Process Cytosol Intracellular Signal Transduction Cytoplasm Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Signal Transduction Protein-containing Complex Regulation Of Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Apoptotic Signaling Pathway Enzyme Binding Cellular Response To Oxygen-containing Compound Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Stress Regulation Of Protein Metabolic Process Positive Regulation Of Signaling Nucleus Regulation Of Neuron Apoptotic Process Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Neuron Apoptotic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Immune System Process Protein Modification Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Immune Response Protein Phosphorylation Negative Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Developmental Process Positive Regulation Of Multicellular Organismal Process	Response To Xenobiotic Stimulus Anterior Neural Tube Closure Rhythmic Process Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Staurosporine Luteolysis Glial Cell Apoptotic Process Response To Ionizing Radiation Phospholipase A2 Activator Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Cellular Response To Luteinizing Hormone Stimulus Dense Fibrillar Component RRNA Metabolic Process Pwp2p-containing Subcomplex Of 90S Preribosome Response To Anesthetic Protein-containing Complex Binding Death-inducing Signaling Complex DNA Topoisomerase Activity Response To Luteinizing Hormone Supercoiled DNA Binding Positive Regulation Of Pyroptotic Inflammatory Response Embryonic Cleavage Response To Cobalt Ion DNA Topological Change Response To Radiation Fibroblast Apoptotic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Activated T Cell Proliferation Interleukin-18-mediated Signaling Pathway Regulation Of Synaptic Vesicle Cycle Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation Positive Regulation Of Amyloid-beta Formation Death Receptor Binding Aspartic-type Endopeptidase Activity Axonal Fasciculation Neuron Projection Fasciculation Protein Poly-ADP-ribosylation DNA Binding, Bending Cellular Response To Gonadotropin Stimulus DNA Conformation Change SnoRNA Binding Response To Hormone Platelet Formation RRNA Transcription Execution Phase Of Apoptosis Positive Regulation Of Amyloid Precursor Protein Catabolic Process Neurotrophin Signaling Pathway Response To X-ray Response To Gonadotropin
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