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CASP3 and MAPK8IP3
Number of citations of the paper that reports this interaction (PMID
10629060
)
49
Data Source:
HPRD
(in vitro)
CASP3
MAPK8IP3
Gene Name
caspase 3, apoptosis-related cysteine peptidase
mitogen-activated protein kinase 8 interacting protein 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Golgi Membrane
Cytoplasm
Smooth Endoplasmic Reticulum
Dendrite
Axolemma
Molecular Function
Aspartic-type Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Peptidase Activity
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
MAP-kinase Scaffold Activity
JUN Kinase Binding
Kinesin Binding
Receptor Signaling Complex Scaffold Activity
Mitogen-activated Protein Kinase Kinase Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Biological Process
B Cell Homeostasis
Release Of Cytochrome C From Mitochondria
Apoptotic DNA Fragmentation
Proteolysis
Apoptotic Process
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Cellular Response To DNA Damage Stimulus
Heart Development
Sensory Perception Of Sound
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Response To UV
Response To Wounding
Extracellular Matrix Disassembly
Neuron Differentiation
Extracellular Matrix Organization
Keratinocyte Differentiation
Erythrocyte Differentiation
Platelet Formation
Negative Regulation Of B Cell Proliferation
Glial Cell Apoptotic Process
Response To Tumor Necrosis Factor
Hippo Signaling
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Cell Fate Commitment
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Activated T Cell Proliferation
Neurotrophin TRK Receptor Signaling Pathway
Neuron Apoptotic Process
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Regulation Of Apoptotic DNA Fragmentation
In Utero Embryonic Development
Activation Of JUN Kinase Activity
Axon Guidance
Respiratory Gaseous Exchange
Protein Localization
Post-embryonic Development
Regulation Of Gene Expression
Vesicle-mediated Transport
Forebrain Development
Positive Regulation Of Neuron Differentiation
Regulation Of JNK Cascade
Lung Alveolus Development
Lung Morphogenesis
Pathways
SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
SMAC-mediated apoptotic response
Cytochrome c-mediated apoptotic response
Caspase-mediated cleavage of cytoskeletal proteins
Degradation of the extracellular matrix
Role of DCC in regulating apoptosis
Activation of caspases through apoptosome-mediated cleavage
Activation of DNA fragmentation factor
Apoptotic factor-mediated response
Programmed Cell Death
Intrinsic Pathway for Apoptosis
Signalling by NGF
Apoptotic cleavage of cellular proteins
Cell death signalling via NRAGE, NRIF and NADE
Apoptotic execution phase
p75 NTR receptor-mediated signalling
Stimulation of the cell death response by PAK-2p34
Apoptotic cleavage of cell adhesion proteins
Signaling by Hippo
Apoptosis induced DNA fragmentation
Extrinsic Pathway
NADE modulates death signalling
Drugs
Minocycline
5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
[N-(3-DIBENZYLCARBAMOYL-OXIRANECARBONYL)-HYDRAZINO]-ACETIC ACID
4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
(1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
N-[3-(2-fluoroethoxy)phenyl]-N\'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
Diseases
GWAS
Protein-Protein Interactions
153 interactors:
ACIN1
ADD1
AIFM1
AKAP8
AKT1
APAF1
APP
AR
ARHGDIA
ARHGDIB
ATG4D
ATN1
BCAP31
BCAR1
BCL2
BECN1
BID
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
BLM
BMX
BRCA1
CAD
CASP10
CASP2
CASP4
CASP6
CASP7
CASP8
CASP9
CAST
CDC27
CDC42
CDH1
CDK11B
CDKN1A
CFLAR
COPS6
CRYAB
CTNNB1
CTTN
DBNL
DCC
DCTN1
DEDD
DFFA
DSG3
EIF2AK2
EIF2S1
EIF3J
EIF4B
EIF4G2
FYN
GATA1
GLRX
GMNN
GOLGA3
GORASP1
GRIPAP1
GSN
GZMB
HCLS1
HIP1
HMGB1
HNRNPU
HSPD1
HSPE1
HTT
IL16
IL18
KCNIP3
KRT18
LMNB1
LYN
MAP4K1
MAPK8
MAPK8IP3
MAPK9
MAPT
MCL1
MDC1
MDM2
MDM4
MEF2A
MET
MLH1
MYL3
NDUFS1
NEDD4
NFE2L2
NMT2
PAK2
PARG
PARP1
PDE10A
PDE5A
PICALM
PIP5K1A
PKN1
PKN2
PLA2G4A
PLA2G4B
PPP3CA
PRKCQ
PRKCZ
PRKDC
PSEN1
PSEN2
PSIP1
PSME3
PTBP1
PTGES3
PTMA
PXN
RABEP1
RAC1
RAD51
RASA1
RB1
RFC1
RNF2
ROCK1
SARS2
SLK
SOCS5
SP1
SPTAN1
SREBF2
SRF
SRP72
STAT1
STK24
STK3
STK4
TFAP2A
TGM2
THAP11
TNFSF10
TOP1
TRAF1
TRAF3
UBE4B
USO1
VAV1
VIM
WEE1
XIAP
YWHAE
YWHAG
ZBTB16
21 interactors:
ARL4D
CASP3
KLC1
KLC2
MAP2K1
MAP2K4
MAP2K7
MAP3K11
MAP3K5
MAPK10
MAPK8
MAPK8IP1
MAPK8IP2
MAPK9
PTK2
RAF1
RIC8A
SRC
TLR2
TLR4
TLR9
Entrez ID
836
23162
HPRD ID
02799
12014
Ensembl ID
ENSG00000164305
ENSG00000138834
Uniprot IDs
A8MVM1
P42574
E9PFH7
Q9UPT6
PDB IDs
1CP3
1GFW
1I3O
1NME
1NMQ
1NMS
1PAU
1QX3
1RE1
1RHJ
1RHK
1RHM
1RHQ
1RHR
1RHU
2C1E
2C2K
2C2M
2C2O
2CDR
2CJX
2CJY
2CNK
2CNL
2CNN
2CNO
2DKO
2H5I
2H5J
2H65
2J30
2J31
2J32
2J33
2XYG
2XYH
2XYP
2XZD
2XZT
2Y0B
3DEH
3DEI
3DEJ
3DEK
3EDQ
3GJQ
3GJR
3GJS
3GJT
3H0E
3ITN
3KJF
3PCX
3PD0
3PD1
4DCJ
4DCO
4DCP
4EHA
4EHD
4EHF
4EHH
4EHK
4EHL
4EHN
4JJE
4JQY
4JQZ
4JR0
Enriched GO Terms of Interacting Partners
?
Cell Death
Programmed Cell Death
Apoptotic Process
Death
Regulation Of Cell Death
Regulation Of Apoptotic Process
Execution Phase Of Apoptosis
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Regulation Of Protein Metabolic Process
Cellular Response To Stimulus
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Cell Communication
Positive Regulation Of Cell Death
Positive Regulation Of Programmed Cell Death
Response To Stimulus
Regulation Of Catalytic Activity
Response To Stress
Signal Transduction
Positive Regulation Of Cellular Metabolic Process
Signaling
Positive Regulation Of Apoptotic Process
Regulation Of Metabolic Process
Regulation Of Signal Transduction
Apoptotic Signaling Pathway
Intracellular Signal Transduction
Negative Regulation Of Programmed Cell Death
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Signaling
Positive Regulation Of Catalytic Activity
Regulation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Cell Death
Regulation Of Endopeptidase Activity
Negative Regulation Of Apoptotic Process
Regulation Of Cellular Component Organization
Regulation Of Peptidase Activity
Positive Regulation Of Signal Transduction
Regulation Of Cellular Process
Regulation Of Proteolysis
Cellular Response To Stress
Immune System Process
Multicellular Organismal Development
Anatomical Structure Development
Developmental Process
Response To Organic Substance
System Development
Cell Differentiation
Intrinsic Apoptotic Signaling Pathway
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
MyD88-dependent Toll-like Receptor Signaling Pathway
MAPK Cascade
JNK Cascade
Positive Regulation Of Signal Transduction
Regulation Of Protein Kinase Activity
Signal Transduction By Phosphorylation
Toll-like Receptor TLR6:TLR2 Signaling Pathway
Toll-like Receptor TLR1:TLR2 Signaling Pathway
Regulation Of Kinase Activity
Toll-like Receptor Signaling Pathway
Toll-like Receptor 2 Signaling Pathway
Regulation Of Stress-activated MAPK Cascade
Regulation Of Protein Phosphorylation
Regulation Of MAPK Cascade
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Kinase Activity
Intracellular Signal Transduction
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Positive Regulation Of Kinase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Protein Metabolic Process
Activation Of Innate Immune Response
Toll-like Receptor 4 Signaling Pathway
Positive Regulation Of Protein Phosphorylation
Protein Phosphorylation
Regulation Of Phosphorylation
Positive Regulation Of Transferase Activity
Regulation Of JNK Cascade
Regulation Of Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of MAP Kinase Activity
Response To Stress
Positive Regulation Of Innate Immune Response
Phosphorylation
Positive Regulation Of MAPK Cascade
Positive Regulation Of Phosphorylation
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Protein Modification Process
Toll-like Receptor 9 Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Tagcloud
?
abeta1
accelerated
amyloid
apoe4
bace1
becomes
deposits
event
hallmark
hyperphosphorylation
increasingly
later
losses
nonetheless
nonsynonymous
nontransgenic
oxys
picalm
posits
precede
proof
psen1
psen2
snps
sorl1
sporadic
triggers
turn
unlikely
Tagcloud (Difference)
?
abeta1
accelerated
amyloid
apoe4
bace1
becomes
deposits
event
hallmark
hyperphosphorylation
increasingly
later
losses
nonetheless
nonsynonymous
nontransgenic
oxys
picalm
posits
precede
proof
psen1
psen2
snps
sorl1
sporadic
triggers
turn
unlikely
Tagcloud (Intersection)
?