CASP3 and CASP7

Number of citations of the paper that reports this interaction (PubMedID 18723680)
17

Data Source:
BioGRID (enzymatic study)

		CASP3	CASP7
Description		caspase 3	caspase 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Death-inducing Signaling Complex Neuronal Cell Body Glutamatergic Synapse	Fibrillar Center Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protease Binding Endopeptidase Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Death Receptor Binding Protein Binding Enzyme Activator Activity Peptidase Activity Cysteine-type Peptidase Activity Phospholipase A2 Activator Activity Hydrolase Activity Protein-containing Complex Binding	RNA Binding Catalytic Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Luteolysis Response To Hypoxia B Cell Homeostasis Negative Regulation Of Cytokine Production Proteolysis Apoptotic Process DNA Damage Response Axonal Fasciculation Heart Development Sensory Perception Of Sound Learning Or Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Response To Xenobiotic Stimulus Response To UV Response To Wounding Response To Glucose Response To Metal Ion Response To X-ray Regulation Of Macroautophagy Protein Processing Hippocampus Development Protein Catabolic Process Neuron Differentiation Keratinocyte Differentiation Erythrocyte Differentiation Platelet Formation Negative Regulation Of B Cell Proliferation Regulation Of Protein Stability Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Response To Tumor Necrosis Factor Response To Nicotine Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Response To Hydrogen Peroxide T Cell Homeostasis Positive Regulation Of Apoptotic Process Response To Amino Acid Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Cell Fate Commitment Negative Regulation Of Cell Cycle Negative Regulation Of Activated T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Striated Muscle Cell Differentiation Response To Glucocorticoid Neuron Apoptotic Process Protein Maturation Anterior Neural Tube Closure Protein Poly-ADP-ribosylation Pyroptotic Inflammatory Response Leukocyte Apoptotic Process Response To Anesthetic Cellular Response To Staurosporine Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Regulation Of Synaptic Vesicle Cycle Positive Regulation Of Pyroptotic Inflammatory Response Positive Regulation Of Amyloid-beta Formation Epithelial Cell Apoptotic Process	Negative Regulation Of Transcription By RNA Polymerase II Plasma Membrane Repair Regulation Of Transcription By RNA Polymerase II Proteolysis Apoptotic Process Heart Development Response To UV Protein Processing Protein Catabolic Process Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Fibroblast Apoptotic Process Ceramide Biosynthetic Process Striated Muscle Cell Differentiation Neuron Apoptotic Process Protein Maturation Protein Poly-ADP-ribosylation Lymphocyte Apoptotic Process Pyroptotic Inflammatory Response Cellular Response To Lipopolysaccharide Leukocyte Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis Positive Regulation Of Plasma Membrane Repair
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Apoptosis induced DNA fragmentation Degradation of the extracellular matrix Signaling by Hippo NADE modulates death signalling Stimulation of the cell death response by PAK-2p34 Caspase-mediated cleavage of cytoskeletal proteins Apoptotic cleavage of cell adhesion proteins Caspase activation via Dependence Receptors in the absence of ligand Caspase activation via Dependence Receptors in the absence of ligand Other interleukin signaling Pyroptosis CASP4-mediated substrate cleavage CASP5-mediated substrate cleavage	Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins
Drugs		Pamidronic acid Acetylsalicylic acid Minocycline 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid Emricasan Incadronic acid 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE [N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide Tributyrin Oleandrin PAC-1 Glycyrrhizic acid	Fica Emricasan Incadronic acid
Diseases
GWAS		Hippocampal volume in Alzheimer's disease dementia ( 29274321) Kawasaki disease ( 33106546 33772158)	Cataracts ( 34127677) Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 22561518 27723757)
Interacting Genes		157 interacting genes: ACIN1 ADD1 AFP AIFM1 AKAP8 AKT1 APAF1 APP AR ARHGDIA ARHGDIB ARNT ATG4D ATN1 BCAP31 BCAR1 BCL2 BECN1 BID BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BLM BMX BRCA1 CAD CASP10 CASP2 CASP4 CASP6 CASP7 CASP8 CASP9 CAST CDC27 CDC42 CDH1 CDK11B CDKN1A CFLAR COPS6 CRYAB CTNNB1 CTTN DBNL DCC DCTN1 DEDD DFFA DSG3 EIF2AK2 EIF2S1 EIF3J EIF4B EIF4G2 FYN GATA1 GLRX GMNN GOLGA3 GORASP1 GRIPAP1 GSN GZMB HCLS1 HIP1 HMGB1 HNRNPU HSPD1 HSPE1 HTT IL16 IL18 KCNIP3 KRT18 LMNB1 LYN MAP4K1 MAPK8 MAPK8IP3 MAPK9 MAPT MCL1 MDC1 MDM2 MDM4 MEF2A MET MLH1 MYL3 NDUFS1 NEDD4 NFE2L2 NMT2 PAK2 PARG PARP1 PDE10A PDE5A PICALM PIP5K1A PKN1 PKN2 PLA2G4A PLA2G4B PPP3CA PRKCQ PRKCZ PRKDC PSEN1 PSEN2 PSIP1 PSME3 PTBP1 PTGES3 PTMA PXN RABEP1 RAC1 RAD51 RASA1 RB1 RFC1 RNF2 ROCK1 SARS2 SLK SNRNP70 SOCS5 SOHLH1 SP1 SPTAN1 SREBF2 SRF SRP72 STAT1 STK24 STK3 STK4 TFAP2A TGM2 THAP11 TNFSF10 TOP1 TRAF1 TRAF3 UBE4B USO1 VAV1 VIM WEE1 XIAP YWHAE YWHAG ZBTB16	63 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HNRNPH1 HSPA5 KRT18 LYN MAGEA11 MAPT MAX MEF2A MEF2D NEDD4 NIF3L1 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A TRIM25 UBE4B VIM XIAP
Entrez ID		836	840
HPRD ID		02799	03457
Ensembl ID		ENSG00000164305	ENSG00000165806
Uniprot IDs		A8MVM1 P42574	A0A0A0MRL7 B4DWA2 P55210
PDB IDs		1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4PRY 4PS0 4QTX 4QTY 4QU0 4QU5 4QU8 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL 5I9B 5I9T 5IAB 5IAE 5IAG 5IAJ 5IAK 5IAN 5IAR 5IAS 5IBC 5IBP 5IBR 5IC4 7XN4 7XN5 7XN6	1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z 7WZS 8DGZ 8DJ3
Enriched GO Terms of Interacting Partners?		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cell Death Programmed Cell Death Apoptotic Process Cytosol Intracellular Signal Transduction Cytoplasm Positive Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Signal Transduction Protein-containing Complex Regulation Of Apoptotic Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Apoptotic Signaling Pathway Enzyme Binding Cellular Response To Oxygen-containing Compound Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Stress Regulation Of Protein Metabolic Process Positive Regulation Of Signaling Nucleus Regulation Of Neuron Apoptotic Process Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Neuron Apoptotic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Immune System Process Protein Modification Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Immune Response Protein Phosphorylation Negative Regulation Of Cellular Component Organization Positive Regulation Of Macromolecule Metabolic Process Developmental Process Positive Regulation Of Multicellular Organismal Process	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Apoptotic Process Programmed Cell Death Cell Death Cytosol Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Nucleus Cytoplasm Intracellular Signal Transduction Enzyme Binding Regulation Of Primary Metabolic Process Negative Regulation Of Cellular Component Organization Protein-containing Complex Positive Regulation Of Macromolecule Metabolic Process Response To Stress Execution Phase Of Apoptosis Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Neuron Apoptotic Process Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cellular Component Organization Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Signal Transduction Cellular Response To Stress Myeloid Cell Differentiation Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Protein-containing Complex Assembly Regulation Of Signaling Regulation Of Cell Communication Regulation Of Necroptotic Process Protein Metabolic Process Cysteine-type Endopeptidase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteolysis Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Protein Maturation Regulation Of Programmed Necrotic Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process DNA-binding Transcription Factor Binding Protein Processing
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