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CASP3 and MDM2
Number of citations of the paper that reports this interaction (PubMedID
24842904
)
61
Data Source:
BioGRID
(imaging technique, enzymatic study, enzymatic study, enzymatic study)
HPRD
(in vitro)
CASP3
MDM2
Description
caspase 3
MDM2 proto-oncogene
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Postsynaptic Density
Death-inducing Signaling Complex
Neuronal Cell Body
Glutamatergic Synapse
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Postsynaptic Density
Nuclear Body
Transcription Repressor Complex
Endocytic Vesicle Membrane
Protein-containing Complex
Centriolar Satellite
Glutamatergic Synapse
Molecular Function
Protease Binding
Endopeptidase Activity
Aspartic-type Endopeptidase Activity
Cysteine-type Endopeptidase Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Death Receptor Binding
Protein Binding
Enzyme Activator Activity
Peptidase Activity
Cysteine-type Peptidase Activity
Phospholipase A2 Activator Activity
Hydrolase Activity
Protein-containing Complex Binding
P53 Binding
Ubiquitin-protein Transferase Activity
Protein Binding
5S RRNA Binding
Zinc Ion Binding
Transferase Activity
Ligase Activity
SUMO Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Receptor Serine/threonine Kinase Binding
Identical Protein Binding
Peroxisome Proliferator Activated Receptor Binding
Ribonucleoprotein Complex Binding
Ubiquitin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Disordered Domain Specific Binding
Biological Process
Luteolysis
Response To Hypoxia
B Cell Homeostasis
Negative Regulation Of Cytokine Production
Proteolysis
Apoptotic Process
DNA Damage Response
Axonal Fasciculation
Heart Development
Sensory Perception Of Sound
Learning Or Memory
Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress
Response To Xenobiotic Stimulus
Response To UV
Response To Wounding
Response To Glucose
Response To Metal Ion
Response To X-ray
Regulation Of Macroautophagy
Protein Processing
Hippocampus Development
Protein Catabolic Process
Neuron Differentiation
Keratinocyte Differentiation
Erythrocyte Differentiation
Platelet Formation
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Stability
Response To Cobalt Ion
Response To Estradiol
Response To Lipopolysaccharide
Glial Cell Apoptotic Process
Response To Tumor Necrosis Factor
Response To Nicotine
Intracellular Signal Transduction
Interleukin-18-mediated Signaling Pathway
Response To Hydrogen Peroxide
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Response To Amino Acid
Positive Regulation Of Neuron Apoptotic Process
Fibroblast Apoptotic Process
Cell Fate Commitment
Negative Regulation Of Cell Cycle
Negative Regulation Of Activated T Cell Proliferation
Neurotrophin TRK Receptor Signaling Pathway
Striated Muscle Cell Differentiation
Response To Glucocorticoid
Neuron Apoptotic Process
Protein Maturation
Anterior Neural Tube Closure
Protein Poly-ADP-ribosylation
Pyroptotic Inflammatory Response
Leukocyte Apoptotic Process
Response To Anesthetic
Cellular Response To Staurosporine
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Execution Phase Of Apoptosis
Regulation Of Synaptic Vesicle Cycle
Positive Regulation Of Pyroptotic Inflammatory Response
Positive Regulation Of Amyloid-beta Formation
Epithelial Cell Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
Blood Vessel Development
Blood Vessel Remodeling
Regulation Of Heart Rate
Heart Valve Development
Atrioventricular Valve Morphogenesis
Endocardial Cushion Morphogenesis
Ventricular Septum Development
Atrial Septum Development
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Traversing Start Control Point Of Mitotic Cell Cycle
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Response To Toxic Substance
Response To Iron Ion
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Protein Processing
Negative Regulation Of Neuron Projection Development
Protein Ubiquitination
Protein Sumoylation
DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein Destabilization
Response To Magnesium Ion
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Localization To Nucleus
Regulation Of Protein Catabolic Process
Response To Cocaine
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Protein-containing Complex Organization
Establishment Of Protein Localization
Response To Ether
Positive Regulation Of Cell Cycle
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of Mitotic Cell Cycle
Response To Antibiotic
Positive Regulation Of Protein Export From Nucleus
Response To Steroid Hormone
Positive Regulation Of Muscle Cell Differentiation
Proteolysis Involved In Protein Catabolic Process
Regulation Of Cell Cycle
Protein Autoubiquitination
Cardiac Septum Morphogenesis
Protein-containing Complex Assembly
Regulation Of Biological Quality
Cellular Response To Hydrogen Peroxide
Cellular Response To Antibiotic
Cellular Response To Vitamin B1
Cellular Response To Alkaloid
Cellular Response To Growth Factor Stimulus
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Estrogen Stimulus
Cellular Response To Hypoxia
Cellular Response To Gamma Radiation
Cellular Response To UV-C
Signal Transduction By P53 Class Mediator
Fibroblast Activation
Cellular Response To Actinomycin D
Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Negative Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Response To Formaldehyde
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Amyloid Fibril Formation
Response To Water-immersion Restraint Stress
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
SMAC, XIAP-regulated apoptotic response
Apoptosis induced DNA fragmentation
Degradation of the extracellular matrix
Signaling by Hippo
NADE modulates death signalling
Stimulation of the cell death response by PAK-2p34
Caspase-mediated cleavage of cytoskeletal proteins
Apoptotic cleavage of cell adhesion proteins
Caspase activation via Dependence Receptors in the absence of ligand
Caspase activation via Dependence Receptors in the absence of ligand
Other interleukin signaling
Pyroptosis
CASP4-mediated substrate cleavage
CASP5-mediated substrate cleavage
AKT phosphorylates targets in the cytosol
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
Trafficking of AMPA receptors
Constitutive Signaling by AKT1 E17K in Cancer
Ub-specific processing proteases
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Stabilization of p53
Regulation of RUNX3 expression and activity
Signaling by ALK fusions and activated point mutants
Degradation of CDH1
NPAS4 regulates expression of target genes
Drugs
Pamidronic acid
Acetylsalicylic acid
Minocycline
5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid
Emricasan
Incadronic acid
2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID
methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate
1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE
[N-(3-dibenzylcarbamoyl-oxiranecarbonyl)-hydrazino]-acetic acid
4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID
(1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
(1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate
N-[3-(2-fluoroethoxy)phenyl]-N'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
Tributyrin
Oleandrin
PAC-1
Glycyrrhizic acid
Zinc
Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Penile cancer
Alveolar rhabdomyosarcoma
Choriocarcinoma
Osteosarcoma
Glioma
GWAS
Hippocampal volume in Alzheimer's disease dementia (
29274321
)
Kawasaki disease (
33106546
33772158
)
Pneumoconiosis in silica exposure (
24986923
)
Red blood cell count (
32888494
)
Interacting Genes
157 interacting genes:
ACIN1
ADD1
AFP
AIFM1
AKAP8
AKT1
APAF1
APP
AR
ARHGDIA
ARHGDIB
ARNT
ATG4D
ATN1
BCAP31
BCAR1
BCL2
BECN1
BID
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
BLM
BMX
BRCA1
CAD
CASP10
CASP2
CASP4
CASP6
CASP7
CASP8
CASP9
CAST
CDC27
CDC42
CDH1
CDK11B
CDKN1A
CFLAR
COPS6
CRYAB
CTNNB1
CTTN
DBNL
DCC
DCTN1
DEDD
DFFA
DSG3
EIF2AK2
EIF2S1
EIF3J
EIF4B
EIF4G2
FYN
GATA1
GLRX
GMNN
GOLGA3
GORASP1
GRIPAP1
GSN
GZMB
HCLS1
HIP1
HMGB1
HNRNPU
HSPD1
HSPE1
HTT
IL16
IL18
KCNIP3
KRT18
LMNB1
LYN
MAP4K1
MAPK8
MAPK8IP3
MAPK9
MAPT
MCL1
MDC1
MDM2
MDM4
MEF2A
MET
MLH1
MYL3
NDUFS1
NEDD4
NFE2L2
NMT2
PAK2
PARG
PARP1
PDE10A
PDE5A
PICALM
PIP5K1A
PKN1
PKN2
PLA2G4A
PLA2G4B
PPP3CA
PRKCQ
PRKCZ
PRKDC
PSEN1
PSEN2
PSIP1
PSME3
PTBP1
PTGES3
PTMA
PXN
RABEP1
RAC1
RAD51
RASA1
RB1
RFC1
RNF2
ROCK1
SARS2
SLK
SNRNP70
SOCS5
SOHLH1
SP1
SPTAN1
SREBF2
SRF
SRP72
STAT1
STK24
STK3
STK4
TFAP2A
TGM2
THAP11
TNFSF10
TOP1
TRAF1
TRAF3
UBE4B
USO1
VAV1
VIM
WEE1
XIAP
YWHAE
YWHAG
ZBTB16
271 interacting genes:
ABL1
ABL2
ADRB2
AKAP5
AKT1
ANKRD17
APEX1
APOB
APP
AR
ARRB1
ARRB2
ATF3
ATF4
ATM
ATP2A2
ATRX
AURKA
BAIAP2L1
BRINP1
BTK
BTRC
CANX
CASP2
CASP3
CCAR1
CCDC3
CCNG1
CDC34
CDKN2A
CHEK2
CLSTN1
CLU
COPS5
CREBBP
CSNK2A1
CSNK2A2
CSNK2B
CTBP2
CWC25
DAPK1
DAPK3
DAXX
DDX24
DDX42
DHFR
DLG4
DNAJB4
DYRK2
EGLN3
EID1
EP300
ESR1
EZR
F3
FBXO31
FHL2
FKBP1A
FOS
FOXO1
FOXO3
FOXP3
G3BP2
GADD45A
GCAT
GLIS2
GNL3
GORAB
GRK2
GSK3B
GTF2E2
GYS2
H2BC21
H3-4
HCK
HDAC1
HEY1
HIF1A
HIPK2
HLA-DMB
HMGA2
HMGN1
HNRNPK
HSP90B1
IER3
IGF1R
IL33
IRF1
IRF2
JMY
JUN
JUND
KAT2B
KAT5
KIAA1671
KPNA1
LMO7
MAGEA2
MAGEC2
MAP1LC3A
MAP2
MAPKAPK2
MAPT
MDM4
MED1
MKRN3
MS4A1
MTBP
MYC
MYD88
MYDGF
NACA
NAT10
NCL
NDUFS1
NGFR
NOLC1
NOTCH1
NPIPB3
NPM1
NR1I2
NR3C1
NRON
NUCKS1
NUMB
OVOL2
PADI4
PAK6
PBX1
PBXIP1
PDCD1
PDE4D
PDIA3
PDLIM7
PDS5A
PGAM2
PHF7
PHLDB3
PIAS1
PJA1
PKM
PLK1
PML
POLE
POT1
PPIB
PPM1D
PPP1R10
PRDM2
PRKN
PSMA3
PSMC5
PSMD10
PSMD4
PSME3
PTK2
RAB8A
RAD23A
RALY
RANBP1
RANBP2
RARA
RASSF1
RB1
RBBP6
RBM10
RBM38
RESF1
RIDA
RLIM
RNF10
RNF115
RNF126
RNF8
RPL11
RPL22
RPL26
RPL36A
RPL4
RPL5
RPS23
RPS3
RPS5
RRM2B
RRP1
RSL1D1
RUVBL2
RYBP
RYR2
S100A1
S100A2
S100A4
S100A6
S100B
SDHC
SESN2
SET
SETD7
SETDB1
SHPK
SIRT2
SIRT3
SMARCA2
SMARCA4
SMARCE1
SMG7
SNCA
SORBS2
SRC
SREK1
SRSF11
SUMO1
TAF1
TBP
TCAP
TFIP11
TOP1
TP53
TP53I3
TP53RK
TP73
TPR
TPT1
TRAF5
TRIB3
TRIM13
TRIM23
TRIM27
TRIM4
TRIM9
TSG101
UBB
UBC
UBE2A
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G2
UBE2H
UBE2I
UBE2J2
UBE2K
UBE2L3
UBE2N
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
UBE2S
UBE2U
UBE2Z
UBE3A
UBQLN4
UBTF
USP15
USP2
USP7
VCP
VEGFA
WRN
WT1
XBP1
XIAP
XPC
YY1AP1
ZNF133
ZNF420
Entrez ID
836
4193
HPRD ID
02799
01272
Ensembl ID
ENSG00000164305
ENSG00000135679
Uniprot IDs
A8MVM1
P42574
A0A0A8KB75
A7UKX7
A7UKX8
A7UKX9
G3XA89
Q00987
Q96DS0
PDB IDs
1CP3
1GFW
1I3O
1NME
1NMQ
1NMS
1PAU
1QX3
1RE1
1RHJ
1RHK
1RHM
1RHQ
1RHR
1RHU
2C1E
2C2K
2C2M
2C2O
2CDR
2CJX
2CJY
2CNK
2CNL
2CNN
2CNO
2DKO
2H5I
2H5J
2H65
2J30
2J31
2J32
2J33
2XYG
2XYH
2XYP
2XZD
2XZT
2Y0B
3DEH
3DEI
3DEJ
3DEK
3EDQ
3GJQ
3GJR
3GJS
3GJT
3H0E
3ITN
3KJF
3PCX
3PD0
3PD1
4DCJ
4DCO
4DCP
4EHA
4EHD
4EHF
4EHH
4EHK
4EHL
4EHN
4JJE
4JQY
4JQZ
4JR0
4PRY
4PS0
4QTX
4QTY
4QU0
4QU5
4QU8
4QU9
4QUA
4QUB
4QUD
4QUE
4QUG
4QUH
4QUI
4QUJ
4QUL
5I9B
5I9T
5IAB
5IAE
5IAG
5IAJ
5IAK
5IAN
5IAR
5IAS
5IBC
5IBP
5IBR
5IC4
7XN4
7XN5
7XN6
1RV1
1T4E
1T4F
1YCR
1Z1M
2AXI
2C6A
2C6B
2F1Y
2FOP
2GV2
2HDP
2LZG
2M86
2MPS
2RUH
2VJE
2VJF
3EQS
3G03
3IUX
3IWY
3JZK
3JZR
3JZS
3LBK
3LBL
3LNJ
3LNZ
3MQS
3TJ2
3TPX
3TU1
3V3B
3VBG
3VZV
3W69
4DIJ
4ERE
4ERF
4HBM
4HFZ
4HG7
4JV7
4JV9
4JVE
4JVR
4JWR
4MDN
4MDQ
4OAS
4OBA
4OCC
4ODE
4ODF
4OGN
4OGT
4OGV
4OQ3
4QO4
4QOC
4UD7
4UE1
4UMN
4WT2
4XXB
4ZFI
4ZGK
4ZYC
4ZYF
4ZYI
5AFG
5C5A
5HMH
5HMI
5HMK
5J7F
5J7G
5LAV
5LAW
5LAY
5LAZ
5LN2
5MNJ
5OAI
5OC8
5SWK
5TRF
5UMM
5VK0
5WTS
5XXK
5Z02
5ZXF
6AAW
6GGN
6H22
6HFA
6I29
6I3S
6IM9
6KZU
6Q96
6Q9H
6Q9L
6Q9O
6SQO
6T2D
6T2E
6T2F
6Y4Q
6YR6
7AD0
7AI0
7AI1
7AYE
7BIR
7BIT
7BIV
7BJ0
7BJ6
7BMG
7KJM
7NA1
7NA2
7NA3
7NA4
7NUS
7QDQ
8AEU
8BGU
8EI9
8EIA
8EIB
8EIC
8F0Z
8F10
8F12
8F13
8GCG
8J81
8P0D
8PWC
9GFC
Enriched GO Terms of Interacting Partners
?
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Cell Death
Programmed Cell Death
Apoptotic Process
Cytosol
Intracellular Signal Transduction
Cytoplasm
Positive Regulation Of Programmed Cell Death
Negative Regulation Of Programmed Cell Death
Signal Transduction
Negative Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Regulation Of Signal Transduction
Protein-containing Complex
Regulation Of Apoptotic Signaling Pathway
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Intracellular Signal Transduction
Apoptotic Signaling Pathway
Enzyme Binding
Cellular Response To Oxygen-containing Compound
Regulation Of Cellular Component Organization
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Response To Stress
Regulation Of Extrinsic Apoptotic Signaling Pathway
Cellular Response To Stress
Regulation Of Protein Metabolic Process
Positive Regulation Of Signaling
Nucleus
Regulation Of Neuron Apoptotic Process
Protein Metabolic Process
Positive Regulation Of Cell Communication
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Regulation Of Immune System Process
Protein Modification Process
Negative Regulation Of Metabolic Process
Macromolecule Metabolic Process
Positive Regulation Of Immune System Process
Negative Regulation Of Apoptotic Signaling Pathway
Regulation Of Immune Response
Protein Phosphorylation
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Macromolecule Metabolic Process
Developmental Process
Positive Regulation Of Multicellular Organismal Process
Nucleus
Nucleoplasm
Macromolecule Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Cellular Response To Stress
Ubiquitin Conjugating Enzyme Activity
Positive Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of RNA Metabolic Process
Protein Modification Process
Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Protein Metabolic Process
Regulation Of Programmed Cell Death
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Apoptotic Process
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Regulation Of RNA Metabolic Process
Protein Ubiquitination
Regulation Of Signal Transduction
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Proteolysis Involved In Protein Catabolic Process
Positive Regulation Of RNA Biosynthetic Process
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Macromolecule Catabolic Process
DNA Damage Response
Positive Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Signal Transduction By P53 Class Mediator
Cytosol
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of RNA Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Response To Stress
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