CASP3 and BIRC5

Number of citations of the paper that reports this interaction (PMID 9850056)
169

Data Source:
BioGRID (pull down, enzymatic study, pull down)
HPRD (in vitro)

		CASP3	BIRC5
Gene Name		caspase 3, apoptosis-related cysteine peptidase	baculoviral IAP repeat containing 5
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Nuclear Chromosome Chromosome, Centromeric Region Condensed Chromosome Kinetochore Nucleus Cytoplasm Centriole Spindle Cytosol Microtubule Spindle Microtubule Cytoplasmic Microtubule Midbody Interphase Microtubule Organizing Center Chromosome Passenger Complex
	Molecular Function	Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Microtubule Binding Zinc Ion Binding Ran GTPase Binding Tubulin Binding Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Protein Heterodimerization Activity Cofactor Binding Cobalt Ion Binding Chaperone Binding
	Biological Process	B Cell Homeostasis Release Of Cytochrome C From Mitochondria Apoptotic DNA Fragmentation Proteolysis Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To DNA Damage Stimulus Heart Development Sensory Perception Of Sound Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To UV Response To Wounding Extracellular Matrix Disassembly Neuron Differentiation Extracellular Matrix Organization Keratinocyte Differentiation Erythrocyte Differentiation Platelet Formation Negative Regulation Of B Cell Proliferation Glial Cell Apoptotic Process Response To Tumor Necrosis Factor Hippo Signaling T Cell Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cell Fate Commitment Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Activated T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Neuron Apoptotic Process Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Regulation Of Apoptotic DNA Fragmentation	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cytokinesis Transcription, DNA-templated Protein Phosphorylation Chromosome Segregation Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Regulation Of Signal Transduction Protein Ubiquitination Protein Complex Localization Positive Regulation Of Exit From Mitosis Spindle Checkpoint Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle Cell Division Establishment Of Chromosome Localization Mitotic Spindle Assembly Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Pathways		SMAC binds to IAPs SMAC-mediated dissociation of IAP:caspase complexes SMAC-mediated apoptotic response Cytochrome c-mediated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins Degradation of the extracellular matrix Role of DCC in regulating apoptosis Activation of caspases through apoptosome-mediated cleavage Activation of DNA fragmentation factor Apoptotic factor-mediated response Programmed Cell Death Intrinsic Pathway for Apoptosis Signalling by NGF Apoptotic cleavage of cellular proteins Cell death signalling via NRAGE, NRIF and NADE Apoptotic execution phase p75 NTR receptor-mediated signalling Stimulation of the cell death response by PAK-2p34 Apoptotic cleavage of cell adhesion proteins Signaling by Hippo Apoptosis induced DNA fragmentation Extrinsic Pathway NADE modulates death signalling	Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs		Minocycline 5-[4-(1-Carboxymethyl-2-Oxo-Propylcarbamoyl)-Benzylsulfamoyl]-2-Hydroxy-Benzoic Acid 2-HYDROXY-5-(2-MERCAPTO-ETHYLSULFAMOYL)-BENZOIC ACID methyl (3S)-3-[(tert-butoxycarbonyl)amino]-4-oxopentanoate 1-METHYL-5-(2-PHENOXYMETHYL-PYRROLIDINE-1-SULFONYL)-1H-INDOLE-2,3-DIONE [N-(3-DIBENZYLCARBAMOYL-OXIRANECARBONYL)-HYDRAZINO]-ACETIC ACID 4-[5-(2-CARBOXY-1-FORMYL-ETHYLCARBAMOYL)-PYRIDIN-3-YL]-BENZOIC ACID (1S)-2-oxo-1-phenyl-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate (1S)-1-(3-chlorophenyl)-2-oxo-2-[(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-5-yl)amino]ethyl acetate N-[3-(2-fluoroethoxy)phenyl]-N\'-(1,3,4-trioxo-1,2,3,4-tetrahydroisoquinolin-6-yl)butanediamide
Diseases
GWAS			Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		153 interactors: ACIN1 ADD1 AIFM1 AKAP8 AKT1 APAF1 APP AR ARHGDIA ARHGDIB ATG4D ATN1 BCAP31 BCAR1 BCL2 BECN1 BID BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BLM BMX BRCA1 CAD CASP10 CASP2 CASP4 CASP6 CASP7 CASP8 CASP9 CAST CDC27 CDC42 CDH1 CDK11B CDKN1A CFLAR COPS6 CRYAB CTNNB1 CTTN DBNL DCC DCTN1 DEDD DFFA DSG3 EIF2AK2 EIF2S1 EIF3J EIF4B EIF4G2 FYN GATA1 GLRX GMNN GOLGA3 GORASP1 GRIPAP1 GSN GZMB HCLS1 HIP1 HMGB1 HNRNPU HSPD1 HSPE1 HTT IL16 IL18 KCNIP3 KRT18 LMNB1 LYN MAP4K1 MAPK8 MAPK8IP3 MAPK9 MAPT MCL1 MDC1 MDM2 MDM4 MEF2A MET MLH1 MYL3 NDUFS1 NEDD4 NFE2L2 NMT2 PAK2 PARG PARP1 PDE10A PDE5A PICALM PIP5K1A PKN1 PKN2 PLA2G4A PLA2G4B PPP3CA PRKCQ PRKCZ PRKDC PSEN1 PSEN2 PSIP1 PSME3 PTBP1 PTGES3 PTMA PXN RABEP1 RAC1 RAD51 RASA1 RB1 RFC1 RNF2 ROCK1 SARS2 SLK SOCS5 SP1 SPTAN1 SREBF2 SRF SRP72 STAT1 STK24 STK3 STK4 TFAP2A TGM2 THAP11 TNFSF10 TOP1 TRAF1 TRAF3 UBE4B USO1 VAV1 VIM WEE1 XIAP YWHAE YWHAG ZBTB16	22 interactors: AURKA AURKB AURKC BIRC2 BIRC3 BIRC6 CASP3 CASP7 CASP9 CDCA8 CDK1 CDK4 DIABLO EVI5 HIST2H3C HIST3H3 HSP90AA1 INCENP KCNJ6 RASA1 XIAP XPO1
Entrez ID		836	332
HPRD ID		02799	04520
Ensembl ID		ENSG00000164305	ENSG00000089685
Uniprot IDs		A8MVM1 P42574	H3BLT4 O15392
PDB IDs		1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0	1E31 1F3H 1XOX 2QFA 2RAW 2RAX 3UEC 3UED 3UEE 3UEF 3UEG 3UEH 3UEI 3UIG 3UIH 3UII 3UIJ 3UIK 4A0I 4A0J 4A0N
Enriched GO Terms of Interacting Partners?		Cell Death Programmed Cell Death Apoptotic Process Death Regulation Of Cell Death Regulation Of Apoptotic Process Execution Phase Of Apoptosis Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Regulation Of Protein Metabolic Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cell Communication Positive Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Response To Stimulus Regulation Of Catalytic Activity Response To Stress Signal Transduction Positive Regulation Of Cellular Metabolic Process Signaling Positive Regulation Of Apoptotic Process Regulation Of Metabolic Process Regulation Of Signal Transduction Apoptotic Signaling Pathway Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Signaling Positive Regulation Of Catalytic Activity Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cell Death Regulation Of Endopeptidase Activity Negative Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Regulation Of Peptidase Activity Positive Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Proteolysis Cellular Response To Stress Immune System Process Multicellular Organismal Development Anatomical Structure Development Developmental Process Response To Organic Substance System Development Cell Differentiation Intrinsic Apoptotic Signaling Pathway	Cell Division Mitotic Cell Cycle Regulation Of Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Cell Death Regulation Of Proteolysis Mitotic Cell Cycle Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Mitotic Nuclear Division Cell Cycle Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Histone Phosphorylation Positive Regulation Of Protein Metabolic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Cell Cycle Negative Regulation Of Programmed Cell Death Apoptotic Process Regulation Of Protein Metabolic Process Negative Regulation Of Cell Death Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Programmed Cell Death Cell Death Death Regulation Of Cytokinesis Histone-serine Phosphorylation Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Metabolic Process Zymogen Activation Cytokinesis Peptidyl-serine Phosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cell Cycle Process Positive Regulation Of Cysteine-type Endopeptidase Activity Spindle Stabilization Positive Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Mitotic Spindle Organization Positive Regulation Of Protein Ubiquitination Positive Regulation Of Peptidase Activity
Tagcloud ?		abeta1 accelerated amyloid apoe4 bace1 becomes deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely	autophagy bcl2 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Difference) ?		abeta1 accelerated amyloid apoe4 bace1 becomes deposits event hallmark hyperphosphorylation increasingly later losses nonetheless nonsynonymous nontransgenic oxys picalm posits precede proof psen1 psen2 snps sorl1 sporadic triggers turn unlikely	autophagy bcl2 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups vegfa wiley
Tagcloud (Intersection) ?