UBE2E1 and MAP3K1

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		UBE2E1	MAP3K1
Gene Name		ubiquitin-conjugating enzyme E2E 1	mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding JUN Kinase Kinase Activity Protein Kinase Binding
	Biological Process	Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Histone Monoubiquitination Protein Ubiquitination Cytokine-mediated Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ISG15-protein Conjugation Histone H2B Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K48-linked Ubiquitination	Activation Of MAPKK Activity Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Epithelial Cell Morphogenesis Protein Phosphorylation Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of JUN Kinase Activity Apoptotic Mitochondrial Changes Actin Cytoskeleton Organization Regulation Of Cell Migration Positive Regulation Of Actin Filament Polymerization Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Wound Healing Innate Immune Response Eyelid Development In Camera-type Eye Cellular Response To Mechanical Stimulus
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation ISG15 antiviral mechanism Interferon Signaling Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Cytokine Signaling in Immune system APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins Antiviral mechanism by IFN-stimulated genes APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System	Toll Like Receptor 7/8 (TLR7/8) Cascade FCERI mediated MAPK activation Toll Like Receptor TLR6:TLR2 Cascade Toll Like Receptor 2 (TLR2) Cascade Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades MyD88 cascade initiated on plasma membrane Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 5 (TLR5) Cascade Toll Like Receptor 4 (TLR4) Cascade MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Fc epsilon receptor (FCERI) signaling TRAF6 mediated NF-kB activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System
Drugs
Diseases
GWAS			Breast cancer ( 17529967 23535729 20453838 19330030) Triglycerides ( 20686565) Type 2 diabetes ( 23209189)
Protein-Protein Interactions		100 interactors: ARIH2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBWD5 CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCH3 MARCH5 MARCH7 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PARK2 PBX2 POLL POLM RELA RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF25 RNF26 RNF4 RNF40 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM17 TRIM2 TRIM23 TRIM27 TRIM28 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM7 UBA1 UBASH3B UBE2G1 UBE3A UBOX5 UFM1 USP7 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	30 interactors: ACTN1 ARHGAP4 BRCA1 CHUK CRTC1 DCAF7 DTX1 GRB2 GSK3B IKBKB JUN MAP2K4 MAP2K7 MAPK1 MAPK3 MAPK8 MAPK9 NFKBIA NR4A1 PAK1 RAF1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L6 UBE2W YWHAE
Entrez ID		7324	4214
HPRD ID		04225	19599
Ensembl ID		ENSG00000170142	ENSG00000095015
Uniprot IDs		B7Z306 P51965	Q13233
PDB IDs		1XR9 3BZH 4JJQ
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Autoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Cellular Metabolic Process Protein Monoubiquitination Proteolysis Catabolic Process Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Proteasomal Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Ubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Histone H2A Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Histone H2A Monoubiquitination Response To Misfolded Protein Regulation Of Signal Transduction Histone Modification Positive Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Response To DNA Damage Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Cellular Process Positive Regulation Of Protein Catabolic Process	TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Fc Receptor Signaling Pathway Activation Of Innate Immune Response Innate Immune Response Positive Regulation Of Innate Immune Response Toll-like Receptor 5 Signaling Pathway Cellular Response To Organic Substance Toll-like Receptor 10 Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Regulation Of Immune Response MyD88-dependent Toll-like Receptor Signaling Pathway Regulation Of Innate Immune Response Cellular Response To Growth Factor Stimulus Response To Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response Regulation Of Immune System Process Response To Abiotic Stimulus Response To Organic Substance Defense Response Positive Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Response To Stress Positive Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Cellular Response To Stress Immune System Process Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2i ube2n ube2z ubiquitin ubiquitination	5q11 alleles ancestry attempt biologically coincided composing consortium gata3 gwass ichav1 ichav2 ichav2a ichav3 looping minor pcond prioritized ptrend rs113317823 rs11949391 rs16886397 rs17432750 rs62355900 rs62355902 rs74345699 rs889312 strongest variants
Tagcloud (Difference) ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2i ube2n ube2z ubiquitin ubiquitination	5q11 alleles ancestry attempt biologically coincided composing consortium gata3 gwass ichav1 ichav2 ichav2a ichav3 looping minor pcond prioritized ptrend rs113317823 rs11949391 rs16886397 rs17432750 rs62355900 rs62355902 rs74345699 rs889312 strongest variants
Tagcloud (Intersection) ?