UBE2E1 and MUL1

Number of citations of the paper that reports this interaction (PubMedID 28763789)
37

Data Source:
BioGRID (pull down)

		UBE2E1	MUL1
Description		ubiquitin conjugating enzyme E2 E1	mitochondrial E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol	Mitochondrion Mitochondrial Outer Membrane Peroxisome Membrane Axon Neuronal Cell Body
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	P53 Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Transcription By RNA Polymerase II Protein K48-linked Ubiquitination	Protein Polyubiquitination Mitochondrial Fission Apoptotic Process Positive Regulation Of Metabolic Process Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Protein Ubiquitination Protein Sumoylation Regulation Of Anatomical Structure Morphogenesis Regulation Of Protein Stability Protein Destabilization Positive Regulation Of Protein Sumoylation Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Positive Regulation Of Developmental Process Mitochondrion Localization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Dendrite Extension Positive Regulation Of Type 2 Mitophagy
Pathways		ISG15 antiviral mechanism Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Ub-specific processing proteases Neddylation KEAP1-NFE2L2 pathway
Drugs
Diseases
GWAS		Academic attainment (English) ( 33594131) Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) Metabolite levels ( 23823483)	Proportion of activated microglia (inferior temporal cortex) ( 30679421)
Interacting Genes		116 interacting genes: ARIH2 ARK2C ASXL2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 FBXO7 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCHF2 MARCHF3 MARCHF5 MARCHF7 MDM2 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PBX2 POLL POLM PRKN RBX1 RELA RFWD3 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF26 RNF31 RNF34 RNF4 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM3 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM69 TRIM7 UBA1 UBA6 UBA7 UBASH3B UBC UBE2G1 UBE3A UBOX5 UBR5 UBR7 UFM1 USP7 UVSSA WWP2 XIAP ZNG1E ZNRF1 ZNRF2 ZNRF4	34 interacting genes: AKT1 APPBP2 CDC34 DNM1L EHD1 HTRA2 KRTAP10-8 MAP3K7 RANGAP1 REEP2 STING1 SUMO1 TAP1 TP53 TP73 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2U UBE2V2 UBE2W UBXN7 ULK1
Entrez ID		7324	79594
HPRD ID		04225	07799
Ensembl ID		ENSG00000170142	ENSG00000090432
Uniprot IDs		B7Z306 P51965	Q969V5
PDB IDs		1XR9 3BZH 4JJQ 5LBN 6FGA 8IYA	6K2K 6M2C 6M2D
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Transferase Activity Protein Metabolic Process Zinc Ion Binding Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Metal Ion Binding Macromolecule Metabolic Process Protein Autoubiquitination Catabolic Process Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Ubiquitin Ligase Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Response To Stress Regulation Of Post-translational Protein Modification Cytoplasm Positive Regulation Of Catabolic Process Ubiquitin Binding Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Positive Regulation Of Autophagy DNA Damage Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Negative Regulation Of Signal Transduction Innate Immune Response Regulation Of Signal Transduction Immune System Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Protein Polyubiquitination Modification-dependent Protein Catabolic Process Post-translational Protein Modification Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Ubiquitin-protein Transferase Activity Proteolysis Protein K48-linked Ubiquitination Catabolic Process Protein Metabolic Process Nucleotide Binding ATP Binding Protein K11-linked Ubiquitination Ubiquitin Protein Ligase Binding Protein Monoubiquitination Transferase Activity Proteasomal Protein Catabolic Process Protein Catabolic Process Macromolecule Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process ISG15 Transferase Activity Regulation Of Macroautophagy ISG15-protein Conjugation Cellular Response To Interferon-beta DNA Damage Response Protein K63-linked Ubiquitination Response To Interferon-beta Cellular Response To Stress Cytosol Response To Stress DNA Repair Positive Regulation Of Protein Polyubiquitination Ubiquitin-like Protein Transferase Activity Regulation Of Autophagy Nucleoplasm TORC1 Signaling Negative Regulation Of TORC1 Signaling Apoptotic Mitochondrial Changes DNA Metabolic Process Cellular Response To Nutrient Levels UBC13-MMS2 Complex Protein K6-linked Ubiquitination CGAS/STING Signaling Pathway TOR Signaling Ubiquitin Conjugating Enzyme Complex
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