UBE2E1 and TRIM32

Number of citations of the paper that reports this interaction (PMID 16816390)
14

Data Source:
BioGRID (pull down)

		UBE2E1	TRIM32
Gene Name		ubiquitin-conjugating enzyme E2E 1	tripartite motif containing 32
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Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol	Nucleus Cytoplasm Cytosol Striated Muscle Myosin Thick Filament
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Myosin Binding Tat Protein Binding Translation Initiation Factor Binding Ubiquitin Binding Protein Self-association Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Histone Monoubiquitination Protein Ubiquitination Cytokine-mediated Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ISG15-protein Conjugation Histone H2B Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K48-linked Ubiquitination	Protein Polyubiquitination Response To UV Protein Ubiquitination Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Tumor Necrosis Factor Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Motility
Pathways		Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation ISG15 antiviral mechanism Interferon Signaling Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Cytokine Signaling in Immune system APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins Antiviral mechanism by IFN-stimulated genes APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System	Antigen processing: Ubiquitination & Proteasome degradation Regulation of innate immune responses to cytosolic DNA Cytosolic sensors of pathogen-associated DNA Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		100 interactors: ARIH2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBWD5 CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCH3 MARCH5 MARCH7 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PARK2 PBX2 POLL POLM RELA RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF25 RNF26 RNF4 RNF40 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM17 TRIM2 TRIM23 TRIM27 TRIM28 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM7 UBA1 UBASH3B UBE2G1 UBE3A UBOX5 UFM1 USP7 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	36 interactors: ABI2 ATXN1 CLIP4 DTNBP1 GLIS2 IRAK1 KCTD9 MID2 MYCN PDE9A PIAS3 PIAS4 PTCD2 PTPN11 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP SYT6 TMEM173 TOP1 TRIM23 TRIM27 TRIM5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2U UBQLN1 UBQLN4 VPS11 XIAP
Entrez ID		7324	22954
HPRD ID		04225	03797
Ensembl ID		ENSG00000170142	ENSG00000119401
Uniprot IDs		B7Z306 P51965	Q13049
PDB IDs		1XR9 3BZH 4JJQ	2CT2
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Autoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Cellular Metabolic Process Protein Monoubiquitination Proteolysis Catabolic Process Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Proteasomal Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Ubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Histone H2A Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Histone H2A Monoubiquitination Response To Misfolded Protein Regulation Of Signal Transduction Histone Modification Positive Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Response To DNA Damage Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Cellular Process Positive Regulation Of Protein Catabolic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Regulation Of Innate Immune Response Cellular Protein Modification Process Activation Of Innate Immune Response Protein K63-linked Ubiquitination Positive Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Metabolic Process Cellular Response To Oxygen Levels Cellular Protein Metabolic Process Regulation Of Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response Innate Immune Response-activating Signal Transduction Negative Regulation Of Viral Release From Host Cell TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of Immune Response MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Response To Stimulus Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Viral Release From Host Cell Protein K11-linked Ubiquitination Response To Stress Toll-like Receptor 4 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor Signaling Pathway Regulation Of Gene Expression Proteasomal Protein Catabolic Process Protein Metabolic Process ISG15-protein Conjugation Immune Response-regulating Signaling Pathway Immune Response Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Defense Response Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Response To Stimulus Cellular Protein Catabolic Process Regulation Of RNA Metabolic Process
Tagcloud ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2i ube2n ube2z ubiquitin ubiquitination	arrest binds e3 element ensure impairing interacts largely ligase maintaining modifications negatively oncogenic overexpressed p53 preventing promotes proper regulator responsive senescence stress tightly transcriptionally translational tumorigenesis turn ubiquitin ubiquitination
Tagcloud (Difference) ?		array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2i ube2n ube2z	arrest binds e3 element ensure impairing interacts largely ligase maintaining modifications negatively oncogenic overexpressed p53 preventing promotes proper regulator responsive senescence stress tightly transcriptionally translational tumorigenesis turn
Tagcloud (Intersection) ?		ubiquitin ubiquitination