UBE2E1 and HDAC6

Number of citations of the paper that reports this interaction (PubMedID 17588522)
0

Data Source:
BioGRID (enzymatic study)

		UBE2E1	HDAC6
Description		ubiquitin conjugating enzyme E2 E1	histone deacetylase 6
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Multivesicular Body Centrosome Cytosol Cytoskeleton Microtubule Microtubule Associated Complex Caveola Cilium Microtubule Cytoskeleton Inclusion Body Aggresome Axon Dendrite Cell Leading Edge Protein-containing Complex Ciliary Basal Body Cell Projection Neuron Projection Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Plasma Membrane Bounded Cell Projection Axon Cytoplasm
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding Actin Binding Histone Deacetylase Activity Protein Binding Beta-catenin Binding Microtubule Binding Zinc Ion Binding Transferase Activity Hydrolase Activity Deacetylase Activity Enzyme Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Protein Ligase Binding Protein Lysine Deacetylase Activity Peroxidase Inhibitor Activity ATPase Inhibitor Activity Histone Deacetylase Binding Tubulin Deacetylase Activity Alpha-tubulin Binding Ubiquitin Binding Metal Ion Binding Acetylspermidine Deacetylase Activity Tau Protein Binding Beta-tubulin Binding Misfolded Protein Binding Hsp90 Protein Binding Dynein Complex Binding Histone Deacetylase Activity, Hydrolytic Mechanism
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Gene Expression Protein Ubiquitination ISG15-protein Conjugation Positive Regulation Of Transcription By RNA Polymerase II Protein K48-linked Ubiquitination	Protein Polyubiquitination Response To Amphetamine Chromatin Organization Protein Deacetylation Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Intracellular Protein Transport Autophagy Response To Stress Actin Filament Organization Negative Regulation Of Microtubule Depolymerization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Autophagy Positive Regulation Of Epithelial Cell Migration Negative Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Mitochondrion Organization Negative Regulation Of Neuron Projection Development Macroautophagy Regulation Of Macroautophagy Axonal Transport Of Mitochondrion Neuron Differentiation Negative Regulation Of Protein-containing Complex Assembly Regulation Of Protein Stability Protein Destabilization Lysosome Localization Positive Regulation Of Protein Oligomerization Regulation Of Microtubule-based Process Protein-containing Complex Disassembly Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Response To Heat Response To Immobilization Stress Cellular Response To Topologically Incorrect Protein Aggrephagy Erythrocyte Enucleation Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Fat Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Collateral Sprouting Negative Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Dendrite Morphogenesis Negative Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Response To Corticosterone Mitochondrion Localization Response To Misfolded Protein Positive Regulation Of Synaptic Transmission, Glutamatergic Cilium Assembly Regulation Of Microtubule-based Movement Regulation Of Androgen Receptor Signaling Pathway Dendritic Spine Morphogenesis Cilium Disassembly Type 2 Mitophagy Regulation Of Biological Quality Regulation Of Establishment Of Protein Localization Cellular Response To Hydrogen Peroxide Regulation Of Microtubule Cytoskeleton Organization Aggresome Assembly Polyubiquitinated Misfolded Protein Transport Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Misfolded Protein Cellular Response To Parathyroid Hormone Stimulus Response To Dexamethasone Tubulin Deacetylation Macromolecule Deacylation Polyamine Deacetylation Spermidine Deacetylation Membraneless Organelle Assembly Positive Regulation Of Cellular Response To Oxidative Stress Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Cholangiocyte Proliferation Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Aggrephagy
Pathways		ISG15 antiviral mechanism Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HSF1 activation Notch-HLH transcription pathway Cargo trafficking to the periciliary membrane Transcriptional regulation by RUNX2 RUNX2 regulates osteoblast differentiation Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
Drugs			Valproic acid Decitabine Vorinostat Vorinostat Belinostat Pracinostat Romidepsin Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide Bufexamac
Diseases
GWAS		Academic attainment (English) ( 33594131) Acne (severe) ( 24927181) Extremely high intelligence ( 29520040) Metabolite levels ( 23823483)
Interacting Genes		116 interacting genes: ARIH2 ARK2C ASXL2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBL CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 FBXO7 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCHF2 MARCHF3 MARCHF5 MARCHF7 MDM2 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PBX2 POLL POLM PRKN RBX1 RELA RFWD3 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF26 RNF31 RNF34 RNF4 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM3 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM69 TRIM7 UBA1 UBA6 UBA7 UBASH3B UBC UBE2G1 UBE3A UBOX5 UBR5 UBR7 UFM1 USP7 UVSSA WWP2 XIAP ZNG1E ZNRF1 ZNRF2 ZNRF4	83 interacting genes: ADRB2 APOBEC3G ARHGDIA ATF3 BBS10 BCL3 BCOR BRMS1 CDKN1A CEP70 CRBN CSNK2A2 CYLD DSCR9 DYNLL2 EP300 ERBB2 ERBB3 ERBB4 FBP1 FBXO11 FNTA FNTB GRK2 H2AX H4C16 HDAC11 HES1 HTATIP2 HTATSF1 ISG15 JDP2 KPNA1 LCOR LINC00624 LPXN MAPK1 MAPK3 MAPT MLH1 MOB1A MSH2 NACAD NASP NEDD8 NR0B2 NR3C1 PLAA POLA2 POLDIP2 POLR1B PPP1CC PRDX4 PRKCZ PRKN PROM1 PTOV1 PXN RELB RNF168 RNF31 RUNX2 SEPTIN7 SIRT2 SYK TEKT4 TPPP TRIM50 TUBA1B TUBA4A TUBB TUBB2B UBB UBC UBE2D1 UBE2D3 UBE2E1 UBE2H USP10 VCP VKORC1 ZBTB16 ZNF205
Entrez ID		7324	10013
HPRD ID		04225	02228
Ensembl ID		ENSG00000170142	ENSG00000094631
Uniprot IDs		B7Z306 P51965	B4DZH6 Q9BRX7 Q9UBN7
PDB IDs		1XR9 3BZH 4JJQ 5LBN 6FGA 8IYA	3C5K 3GV4 3PHD 5B8D 5EDU 5KH3 5KH7 5KH9 5WBN 5WPB 6CE6 6CE8 6CEA 6CEC 6CED 6CEE 6CEF 7ZYU 8G43 8G44 8G45
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Transferase Activity Protein Metabolic Process Zinc Ion Binding Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Metal Ion Binding Macromolecule Metabolic Process Protein Autoubiquitination Catabolic Process Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Ubiquitin Ligase Complex Cellular Response To Stress Ubiquitin Protein Ligase Binding Response To Stress Regulation Of Post-translational Protein Modification Cytoplasm Positive Regulation Of Catabolic Process Ubiquitin Binding Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Ubiquitination Positive Regulation Of Autophagy DNA Damage Response Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Protein K6-linked Ubiquitination Negative Regulation Of Signal Transduction Innate Immune Response Regulation Of Signal Transduction Immune System Process Positive Regulation Of Metabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Protein Catabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Signaling	Nucleus Protein Modification Process Cytosol Protein Ubiquitination Post-translational Protein Modification Modification-dependent Protein Catabolic Process Negative Regulation Of Metabolic Process Protein-containing Complex Protein Modification By Small Protein Conjugation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Response To Stress Microtubule Cytoskeleton ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Protein Modification Process ERBB2 Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Protein Deacetylation Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Ubiquitin Protein Ligase Binding Macromolecule Metabolic Process Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Canonical NF-kappaB Signal Transduction Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Nucleoplasm Protein Tag Activity Regulation Of Signal Transduction Negative Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Gene Expression Regulation Of Protein-containing Complex Assembly Glial Cell Differentiation Positive Regulation Of Developmental Process DNA Damage Response Cell Differentiation Cellular Response To Stress Developmental Process Regulation Of DNA-templated Transcription Regulation Of Signaling Regulation Of Cell Communication
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