RIT1 and AP2A1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		RIT1	AP2A1
Description		Ras like without CAAX 1	adaptor related protein complex 2 subunit alpha 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Membrane Coat AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Adaptor Complex Clathrin-coated Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Filopodium Tip Protein-containing Complex Endolysosome Membrane Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding	Protein Binding Protein Kinase Binding Clathrin Adaptor Activity Protein-containing Complex Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Hyaluronan Biosynthetic Process
Pathways		Signalling to p38 via RIT and RIN	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Appendicular lean mass ( 33097823)
Interacting Genes		16 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2	29 interacting genes: AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 DSCAM DUX4 EHD1 EPN1 EPS15 GHR HIP1 NAGPA NUMB PICALM PIN1 PLK2 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1 UBC
Entrez ID		6016	160
HPRD ID		10195	03016
Ensembl ID		ENSG00000143622	ENSG00000196961
Uniprot IDs		Q92963	O95782
PDB IDs		4KLZ
Enriched GO Terms of Interacting Partners?		I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Signal Transduction Wnt Signaling Pathway Paraxial Mesoderm Morphogenesis R-SMAD Binding Intracellular Signaling Cassette Mesoderm Morphogenesis Gastrulation Pericardium Development SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Tissue Development Regulation Of Neuron Projection Development Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Ras Protein Signal Transduction Positive Regulation Of Gene Expression Primary MiRNA Processing Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Neuron Projection Arborization Cell Surface Receptor Signaling Pathway Regulation Of Ossification COPII Vesicle Coating Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Localization SMAD Protein Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Developmental Growth Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cellular Developmental Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytosol Endoderm Development MiRNA Processing Vesicle Coating Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Ureteric Bud Development Negative Regulation Of Ossification Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Cellular Component Organization Mesonephric Epithelium Development	Endocytosis Import Into Cell Vesicle-mediated Transport Clathrin Binding Clathrin Coat Assembly Clathrin-coated Pit Clathrin-coated Vesicle Phospholipid Binding Receptor Internalization Clathrin Coat Of Coated Pit Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Endosome Protein-containing Complex Assembly Phosphatidylinositol-4,5-bisphosphate Binding Ciliary Pocket Membrane Protein-containing Complex Organization Receptor-mediated Endocytosis Plasma Membrane Regulation Of Endocytosis Synaptic Vesicle Endocytosis Presynapse Presynaptic Endocytosis Regulation Of Amyloid-beta Formation Tau Protein Binding Cytoplasmic Vesicle Postsynaptic Neurotransmitter Receptor Internalization Endomembrane System Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Clathrin Vesicle Coat Ciliary Membrane Establishment Of Localization In Cell AP-2 Adaptor Complex Cytosol Establishment Of Protein Localization Vesicle Organization Cadherin Binding SNARE Binding Lipid Binding Endocytic Vesicle Membrane Cellular Component Assembly Glutamatergic Synapse Protein Transport Regulation Of Amide Metabolic Process Synaptic Vesicle Priming Membrane Clathrin Adaptor Activity Calcium Ion Sensor Activity Organelle Organization
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