AP2A1 and TOE1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		AP2A1	TOE1
Gene Name		adaptor-related protein complex 2, alpha 1 subunit	target of EGR1, member 1 (nuclear)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Nucleus Nucleoplasm Nucleolus Nuclear Speck
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	Nucleic Acid Binding Protein Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process
Pathways		Trafficking of GluR2-containing AMPA receptors Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AMPH AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 MYO6 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1	25 interactors: ABCF3 AGGF1 AP2A1 APLP1 CA12 HNRNPF IK IL7R LSM4 PPP1CA PRCC RAB40C RBM39 RBM8A RPS3A SF3B2 SF3B3 SH3GL3 SQSTM1 SRSF6 SUMO1 U2AF1 UNC13B WDR77 WDR83
Entrez ID		160	114034
HPRD ID		03016	18212
Ensembl ID		ENSG00000196961	ENSG00000132773
Uniprot IDs		O95782	B4DEM6 Q96GM8
PDB IDs			2FC6
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Establishment Of Localization In Cell Synaptic Vesicle Transport Cellular Localization Regulation Of Vesicle-mediated Transport Membrane Budding Transport Cellular Protein Complex Assembly Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Synaptic Transmission Signaling Membrane Organization Cell Communication Cellular Macromolecular Complex Assembly Cell-cell Signaling Establishment Of Organelle Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Endocytosis Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Organelle Localization Neuron Development Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Protein Complex Assembly Positive Regulation Of Transport Secretion By Cell Cellular Component Assembly Receptor Internalization Neuron Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of ERBB Signaling Pathway Generation Of Neurons Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Priming ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurogenesis Secretion Neuron Projection Morphogenesis Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	MRNA Metabolic Process RNA Processing MRNA Processing RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA 3'-end Processing RNA 3'-end Processing RNA Metabolic Process Termination Of RNA Polymerase II Transcription Gene Expression Nucleobase-containing Compound Metabolic Process MRNA Export From Nucleus DNA-templated Transcription, Termination RNA Export From Nucleus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Nuclear Export MRNA Transport Nitrogen Compound Metabolic Process RNA Transport Regulation Of Alternative MRNA Splicing, Via Spliceosome Cellular Localization Nuclear-transcribed MRNA Catabolic Process RNA Localization MRNA Catabolic Process Cytoplasmic Transport Establishment Of Localization In Cell Intracellular Transport RNA Catabolic Process Positive Regulation Of Synaptic Vesicle Priming Positive Regulation Of Synaptic Vesicle Exocytosis Interleukin-7-mediated Signaling Pathway Regulation Of MRNA Splicing, Via Spliceosome Nucleocytoplasmic Transport Cellular Metabolic Process Nuclear Transport Negative Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Norepinephrine Stimulus Regulation Of Epithelial Cell Proliferation Regulation Of MRNA Processing PML Body Organization Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Negative Regulation Of T Cell Mediated Cytotoxicity Cellular Process
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