AP2A1 and RAB11FIP2

Number of citations of the paper that reports this interaction (PMID 12364336)
25

Data Source:
HPRD (in vitro)

		AP2A1	RAB11FIP2
Gene Name		adaptor-related protein complex 2, alpha 1 subunit	RAB11 family interacting protein 2 (class I)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Nucleoplasm Endosome Plasma Membrane Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	Protein Binding Rab GTPase Binding Protein Kinase Binding Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Renal Water Homeostasis Water Transport Protein Transport Establishment Of Cell Polarity Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulated Secretory Pathway Transmembrane Transport
Pathways		Trafficking of GluR2-containing AMPA receptors Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses	Vasopressin regulates renal water homeostasis via Aquaporins Aquaporin-mediated transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AMPH AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 MYO6 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1	12 interactors: AP2A1 CXCR2 EHD1 ITSN1 MARK2 MYO5B RAB11A RAB11B RAB11FIP4 RAB25 REPS1 YWHAG
Entrez ID		160	22841
HPRD ID		03016	10548
Ensembl ID		ENSG00000196961	ENSG00000107560
Uniprot IDs		O95782	Q3I768 Q7L804
PDB IDs			2GZD 2GZH 2K6S 3TSO 4C4P
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Establishment Of Localization In Cell Synaptic Vesicle Transport Cellular Localization Regulation Of Vesicle-mediated Transport Membrane Budding Transport Cellular Protein Complex Assembly Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Synaptic Transmission Signaling Membrane Organization Cell Communication Cellular Macromolecular Complex Assembly Cell-cell Signaling Establishment Of Organelle Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Endocytosis Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Organelle Localization Neuron Development Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Protein Complex Assembly Positive Regulation Of Transport Secretion By Cell Cellular Component Assembly Receptor Internalization Neuron Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of ERBB Signaling Pathway Generation Of Neurons Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Priming ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurogenesis Secretion Neuron Projection Morphogenesis Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	Vesicle-mediated Transport Organelle Localization Cellular Localization Transport Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Regulation Of Endocytic Recycling Protein Transport Establishment Of Protein Localization Establishment Of Vesicle Localization Intracellular Protein Transport Endosomal Transport Vesicle Localization Cellular Pigmentation Rab Protein Signal Transduction Endocytosis Protein Localization Establishment Of Organelle Localization Establishment Of Localization In Cell Cellular Protein Localization Pigmentation Regulation Of Vesicle-mediated Transport Chemical Homeostasis Nervous System Development Intracellular Transport Generation Of Neurons Neurogenesis Renal Water Homeostasis Intracellular Signal Transduction Cellular Response To Organic Substance Cell Projection Organization Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Water Transport Fluid Transport Multicellular Organismal Water Homeostasis Homeostatic Process Water Homeostasis Cell Differentiation Positive Regulation Of Cell Migration Neuron Projection Development Negative Regulation Of Neutrophil Apoptotic Process Multivesicular Body Assembly Regulation Of Multivesicular Body Size Positive Regulation Of Cell Motility Exocytosis Positive Regulation Of Cellular Component Movement Receptor-mediated Endocytosis
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