RIT1 and RGL3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RIT1	RGL3
Description		Ras like without CAAX 1	ral guanine nucleotide dissociation stimulator like 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction
Pathways		Signalling to p38 via RIT and RIN	RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Coronary artery disease ( 29212778) Diastolic blood pressure ( 27618447 27618448 27841878) Hypertension ( 27618447 27618448 32709000 31879980) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878 27618447) Systolic blood pressure ( 28135244 27841878 30578418 27618448 27618447)
Interacting Genes		16 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2	6 interacting genes: FAM200A KLHL12 NRAS RIT1 RIT2 RRAS2
Entrez ID		6016	57139
HPRD ID		10195	18844
Ensembl ID		ENSG00000143622	ENSG00000205517
Uniprot IDs		Q92963	Q3MIN7
PDB IDs		4KLZ
Enriched GO Terms of Interacting Partners?		I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Signal Transduction Wnt Signaling Pathway Paraxial Mesoderm Morphogenesis R-SMAD Binding Intracellular Signaling Cassette Mesoderm Morphogenesis Gastrulation Pericardium Development SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Tissue Development Regulation Of Neuron Projection Development Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Ras Protein Signal Transduction Positive Regulation Of Gene Expression Primary MiRNA Processing Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Neuron Projection Arborization Cell Surface Receptor Signaling Pathway Regulation Of Ossification COPII Vesicle Coating Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Localization SMAD Protein Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Developmental Growth Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cellular Developmental Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytosol Endoderm Development MiRNA Processing Vesicle Coating Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Ureteric Bud Development Negative Regulation Of Ossification Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Cellular Component Organization Mesonephric Epithelium Development	Ras Protein Signal Transduction GDP Binding Small GTPase-mediated Signal Transduction G Protein Activity GTPase Activity GTP Binding Intracellular Signaling Cassette Hydrolase Activity Dendritic Tree Positive Regulation Of Schwann Cell Migration Schwann Cell Migration Nucleotide Binding Intracellular Signal Transduction Calmodulin Binding MAPK Cascade Neural Crest Formation Positive Regulation Of Glial Cell Migration Regulation Of Cdc42 Protein Signal Transduction Signal Transduction
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