AP2A1 and SYT7

Number of citations of the paper that reports this interaction (PMID 7791877)
118

Data Source:
HPRD (in vitro)

		AP2A1	SYT7
Gene Name		adaptor-related protein complex 2, alpha 1 subunit	synaptotagmin VII
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Lysosome Plasma Membrane Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	Transporter Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Plasma Membrane Repair Exocytosis Positive Regulation Of Calcium Ion-dependent Exocytosis Regulation Of Insulin Secretion
Pathways		Trafficking of GluR2-containing AMPA receptors Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AMPH AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 MYO6 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1	8 interactors: AP2A1 NRXN1 SIAH1 STX1A STX2 STX3 STX4 SYNCRIP
Entrez ID		160	9066
HPRD ID		03016	11965
Ensembl ID		ENSG00000196961
Uniprot IDs		O95782	F5GZC2 F5H126 F5H1N2 F5H6C1 O43581
PDB IDs			2D8K
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Establishment Of Localization In Cell Synaptic Vesicle Transport Cellular Localization Regulation Of Vesicle-mediated Transport Membrane Budding Transport Cellular Protein Complex Assembly Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Synaptic Transmission Signaling Membrane Organization Cell Communication Cellular Macromolecular Complex Assembly Cell-cell Signaling Establishment Of Organelle Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Endocytosis Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Organelle Localization Neuron Development Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Protein Complex Assembly Positive Regulation Of Transport Secretion By Cell Cellular Component Assembly Receptor Internalization Neuron Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of ERBB Signaling Pathway Generation Of Neurons Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Priming ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurogenesis Secretion Neuron Projection Morphogenesis Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	Synaptic Vesicle Fusion To Presynaptic Membrane Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Neurotransmitter Transport Vesicle Fusion Synaptic Vesicle Exocytosis Vesicle Localization Synaptic Transmission Organelle Fusion Vesicle Docking Membrane Docking Positive Regulation Of Synaptic Transmission Synaptic Vesicle Transport Membrane Fusion Positive Regulation Of Protein Localization To Plasma Membrane Cell-cell Signaling Organelle Localization Secretion By Cell Establishment Of Vesicle Localization Vesicle Organization Regulation Of Protein Localization To Plasma Membrane Secretion Cellular Protein Localization Establishment Of Protein Localization Regulation Of Synaptic Transmission Positive Regulation Of Protein Localization To Cell Surface Establishment Of Organelle Localization Exocytosis Membrane Organization Intracellular Protein Transport Protein Localization Establishment Of Localization In Cell Regulation Of Protein Localization To Cell Surface Response To Hydroperoxide Regulation Of Behavior Cellular Localization Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Regulation Of Insulin Secretion Protein Transport Vesicle-mediated Transport Regulation Of Peptide Hormone Secretion Positive Regulation Of Excitatory Postsynaptic Membrane Potential Intracellular Transport Regulation Of Hormone Secretion Regulation Of Protein Localization Positive Regulation Of Membrane Potential Regulation Of Establishment Of Protein Localization To Plasma Membrane Neuron Projection Development Calcium Ion-dependent Exocytosis Regulation Of Signaling
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