AP2A1 and DPYSL2

Number of citations of the paper that reports this interaction (PubMedID 35831314)
73

Data Source:
BioGRID (pull down, biochemical)

		AP2A1	DPYSL2
Description		adaptor related protein complex 2 subunit alpha 1	dihydropyrimidinase like 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Membrane Coat AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Adaptor Complex Clathrin-coated Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Filopodium Tip Protein-containing Complex Endolysosome Membrane Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Membrane Extracellular Exosome Mitotic Spindle Plasma Membrane Bounded Cell Projection
	Molecular Function	Protein Binding Protein Kinase Binding Clathrin Adaptor Activity Protein-containing Complex Binding Low-density Lipoprotein Particle Receptor Binding	Dihydropyrimidinase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Identical Protein Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Hyaluronan Biosynthetic Process	Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Cell Differentiation
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	CRMPs in Sema3A signaling Recycling pathway of L1
Drugs			Artenimol
Diseases
GWAS		Appendicular lean mass ( 33097823)	Barrett's esophagus or Esophageal adenocarcinoma ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (1df test) ( 32918910) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		29 interacting genes: AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 DSCAM DUX4 EHD1 EPN1 EPS15 GHR HIP1 NAGPA NUMB PICALM PIN1 PLK2 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1 UBC	18 interacting genes: AP2A1 CDC42 CRMP1 DISC1 DPYSL5 DSCAM DSCR9 EXOSC7 GORASP2 GSK3B LEF1 LUC7L NUMB PLD2 ROCK1 TNIK TUBB UBE2I
Entrez ID		160	1808
HPRD ID		03016	03914
Ensembl ID		ENSG00000196961	ENSG00000092964
Uniprot IDs		O95782	A0A1C7CYX9 Q16555 Q59GB4
PDB IDs			2GSE 2VM8 5LXX 5MKV 5MLE 5X1A 5X1C 5X1D 5YZ5 5YZA 5YZB 6JV9 6JVB 7X68 8DNM
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Vesicle-mediated Transport Clathrin Binding Clathrin Coat Assembly Clathrin-coated Pit Clathrin-coated Vesicle Phospholipid Binding Receptor Internalization Clathrin Coat Of Coated Pit Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Endosome Protein-containing Complex Assembly Phosphatidylinositol-4,5-bisphosphate Binding Ciliary Pocket Membrane Protein-containing Complex Organization Receptor-mediated Endocytosis Plasma Membrane Regulation Of Endocytosis Synaptic Vesicle Endocytosis Presynapse Presynaptic Endocytosis Regulation Of Amyloid-beta Formation Tau Protein Binding Cytoplasmic Vesicle Postsynaptic Neurotransmitter Receptor Internalization Endomembrane System Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Clathrin Vesicle Coat Ciliary Membrane Establishment Of Localization In Cell AP-2 Adaptor Complex Cytosol Establishment Of Protein Localization Vesicle Organization Cadherin Binding SNARE Binding Lipid Binding Endocytic Vesicle Membrane Cellular Component Assembly Glutamatergic Synapse Protein Transport Regulation Of Amide Metabolic Process Synaptic Vesicle Priming Membrane Clathrin Adaptor Activity Calcium Ion Sensor Activity Organelle Organization	Glutamatergic Synapse Nervous System Development Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Projection Development Positive Regulation Of Cell-substrate Adhesion Regulation Of Cell Projection Organization Positive Regulation Of Cell-matrix Adhesion System Development Cell Projection Organization Positive Regulation Of Cell Projection Organization Regulation Of Cell Development Regulation Of Neurogenesis Regulation Of Cell-substrate Adhesion Presynapse Cytoskeleton Organization Regulation Of Nervous System Development Wnt Signaling Pathway Neuron Projection Morphogenesis Regulation Of Cell-matrix Adhesion Cell Projection Morphogenesis Dihydropyrimidinase Activity Regulation Of Synapse Organization Regulation Of Cellular Component Organization Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Plasma Membrane Bounded Cell Projection Organization Pyrimidine Nucleobase Catabolic Process Positive Regulation Of Locomotion Regulation Of Dendrite Morphogenesis Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Negative Regulation Of Striated Muscle Tissue Development Negative Regulation Of Muscle Organ Development Negative Regulation Of Muscle Tissue Development Regulation Of Axon Extension Epithelial To Mesenchymal Transition Regulation Of Locomotion Apical Part Of Cell Cytoskeleton Cellular Component Assembly Regulation Of Developmental Process Dendrite Positive Regulation Of Cellular Component Organization Neuron Projection Development Regulation Of Dendrite Development Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Organelle Organization Positive Regulation Of Cell Adhesion Regulation Of Cell Adhesion Beta-catenin Binding Pyrimidine Nucleobase Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?