AP2A1 and DPYSL2

Number of citations of the paper that reports this interaction (PMID 12942088)
54

Data Source:
BioGRID (pull down)

		AP2A1	DPYSL2
Gene Name		adaptor-related protein complex 2, alpha 1 subunit	dihydropyrimidinase-like 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Mitochondrion Cytosol Microtubule Membrane Dendrite Growth Cone Neuronal Cell Body Terminal Bouton Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	Dihydropyrimidinase Activity Protein Binding Protein Kinase Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Response To Amphetamine Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Endocytosis Cytoskeleton Organization Signal Transduction Nervous System Development Axon Guidance Regulation Of Neuron Projection Development Positive Regulation Of Glutamate Secretion Spinal Cord Development Olfactory Bulb Development Response To Cocaine Response To Drug Synaptic Vesicle Transport
Pathways		Trafficking of GluR2-containing AMPA receptors Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses	Axon guidance Semaphorin interactions L1CAM interactions CRMPs in Sema3A signaling Recycling pathway of L1
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AMPH AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 MYO6 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1	14 interactors: AP2A1 CRMP1 DISC1 DPYSL3 DPYSL4 DPYSL5 GORASP2 GSK3B LEF1 NUMB PLD2 ROCK1 TNIK TUBB
Entrez ID		160	1808
HPRD ID		03016	03914
Ensembl ID		ENSG00000196961	ENSG00000092964
Uniprot IDs		O95782	Q16555 Q59GB4
PDB IDs			2GSE 2VM8
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Establishment Of Localization In Cell Synaptic Vesicle Transport Cellular Localization Regulation Of Vesicle-mediated Transport Membrane Budding Transport Cellular Protein Complex Assembly Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Synaptic Transmission Signaling Membrane Organization Cell Communication Cellular Macromolecular Complex Assembly Cell-cell Signaling Establishment Of Organelle Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Endocytosis Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Organelle Localization Neuron Development Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Protein Complex Assembly Positive Regulation Of Transport Secretion By Cell Cellular Component Assembly Receptor Internalization Neuron Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of ERBB Signaling Pathway Generation Of Neurons Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Priming ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurogenesis Secretion Neuron Projection Morphogenesis Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	Pyrimidine Nucleobase Catabolic Process Chemotaxis Axon Guidance Movement Of Cell Or Subcellular Component Generation Of Neurons Cell Morphogenesis Involved In Differentiation Neurogenesis Locomotion Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Neuron Differentiation Nervous System Development Cell Projection Organization Neuron Projection Development Pyrimidine Nucleobase Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Development Response To External Stimulus Cell Differentiation System Development Anatomical Structure Morphogenesis Multicellular Organismal Development Regulation Of Cell Development Anatomical Structure Development Positive Regulation Of Cell Development Response To Stimulus Regulation Of Cell Differentiation Wnt Signaling Pathway Developmental Process Telencephalon Development Canonical Wnt Signaling Pathway Cytoskeleton Organization Forebrain Neuroblast Division Neural Precursor Cell Proliferation Regulation Of Neurogenesis Regulation Of Cellular Component Organization Regulation Of Neuron Projection Development Regulation Of Epithelial Cell Differentiation Positive Regulation Of Neurogenesis Positive Regulation Of Cell Differentiation Forebrain Development Somatic Stem Cell Division Cell Surface Receptor Signaling Pathway Organelle Organization Regulation Of Cell Projection Organization
Tagcloud ?			24months 2de 8months astrocytic avenues coactosin creatine diamond dihydropyrimidinase dynamin e693delta glutamic glyoxalase illuminate isocitrate littermates oligomers pea phosphoprotein phosphoproteins possessed presumed profilin ruby sh3 sypro transgenic triphosphatase vacuolar
Tagcloud (Difference) ?			24months 2de 8months astrocytic avenues coactosin creatine diamond dihydropyrimidinase dynamin e693delta glutamic glyoxalase illuminate isocitrate littermates oligomers pea phosphoprotein phosphoproteins possessed presumed profilin ruby sh3 sypro transgenic triphosphatase vacuolar
Tagcloud (Intersection) ?