RIT1 and RGL1

Number of citations of the paper that reports this interaction (PMID 10545207)
18

Data Source:
HPRD (in vitro)

		RIT1	RGL1
Gene Name		Ras-like without CAAX 1	ral guanine nucleotide dissociation stimulator-like 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane	Cellular_component Cytosol
	Molecular Function	Protein Binding Calmodulin Binding GTP Binding	Ral Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway	Small GTPase Mediated Signal Transduction Positive Regulation Of Ral GTPase Activity Cellular Lipid Metabolic Process Small Molecule Metabolic Process
Pathways		Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Conduct disorder (interaction) ( 18846501) Inflammatory bowel disease ( 23128233)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Response to antidepressants ( 20360315)
Protein-Protein Interactions		14 interactors: AP2A1 CUL3 IFRD1 KLHL12 LRIF1 MLLT4 PTN RALGDS RGL1 RLF SMAD2 SMAD3 SMURF1 SRPK2	4 interactors: APP HRAS RIT1 RIT2
Entrez ID		6016	23179
HPRD ID		10195	12032
Ensembl ID		ENSG00000143622	ENSG00000143344
Uniprot IDs		Q92963	B7Z2W5 F5H6U6 Q9NZL6
PDB IDs
Enriched GO Terms of Interacting Partners?		Signal Transduction Signaling Cell Communication Primary MiRNA Processing Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Signaling Paraxial Mesoderm Morphogenesis Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Signal Transduction Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Nodal Signaling Pathway Regulation Of Metabolic Process Embryonic Foregut Morphogenesis Foregut Morphogenesis Paraxial Mesoderm Development COPII Vesicle Coating Anatomical Structure Development Transforming Growth Factor Beta Receptor Signaling Pathway Production Of MiRNAs Involved In Gene Silencing By MiRNA COPII-coated Vesicle Budding Pericardium Development Regulation Of Cell Proliferation Response To Stimulus Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Transforming Growth Factor Beta Stimulus Vesicle Targeting, To, From Or Within Golgi Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Gastrulation Developmental Process In Utero Embryonic Development Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of Metabolic Process Posttranscriptional Gene Silencing Protein Monoubiquitination Vesicle Targeting Localization Within Membrane	Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Axon Guidance Visual Learning Axonogenesis Visual Behavior Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Response To Growth Factor Small GTPase Mediated Signal Transduction Associative Learning Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Olfactory Bulb Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Learning Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Striatal Medium Spiny Neuron Differentiation Synaptic Growth At Neuromuscular Junction Cell Morphogenesis Neuron Differentiation Cell Projection Organization Collateral Sprouting In Absence Of Injury Ras Protein Signal Transduction Locomotion Positive Regulation Of Transcription, DNA-templated Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Rac Protein Signal Transduction Regulation Of Epithelial Cell Proliferation Cognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of MiRNA Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Axon Choice Point Recognition Positive Regulation Of Ruffle Assembly Generation Of Neurons Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		aberrations adenocarcinoma adenocarcinomas copy driver eighteen exclusive explained focal foundation highlighted megabase messenger met mga microrna mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic splicing unexplained worldwide
Tagcloud (Difference) ?		aberrations adenocarcinoma adenocarcinomas copy driver eighteen exclusive explained focal foundation highlighted megabase messenger met mga microrna mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic splicing unexplained worldwide
Tagcloud (Intersection) ?