RIT1 and IFRD1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
HPRD (two hybrid)

		RIT1	IFRD1
Description		Ras like without CAAX 1	interferon related developmental regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Cytoplasm Sarcoplasm
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Regulation Of Transcription By RNA Polymerase II Myoblast Fate Determination Striated Muscle Tissue Development Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Axon Extension Muscle Cell Differentiation Skeletal Muscle Tissue Regeneration Fat Cell Differentiation Negative Regulation Of Collateral Sprouting Adipose Tissue Development
Pathways		Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Amyotrophic lateral sclerosis (age of onset) ( 22959728) Dental caries (decayed, missing and filled teeth) ( 31533690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Mortality in heart failure ( 20400778) Osteoarthritis (hip) ( 23989986) Refractive error ( 32231278)
Interacting Genes		16 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2	7 interacting genes: CSNK2A1 HDAC2 HDAC4 KLHL41 MYOD1 PDE4B RIT1
Entrez ID		6016	3475
HPRD ID		10195	04612
Ensembl ID		ENSG00000143622	ENSG00000006652
Uniprot IDs		Q92963	A4D0U1 O00458
PDB IDs		4KLZ
Enriched GO Terms of Interacting Partners?		I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Signal Transduction Wnt Signaling Pathway Paraxial Mesoderm Morphogenesis R-SMAD Binding Intracellular Signaling Cassette Mesoderm Morphogenesis Gastrulation Pericardium Development SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Tissue Development Regulation Of Neuron Projection Development Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Ras Protein Signal Transduction Positive Regulation Of Gene Expression Primary MiRNA Processing Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Neuron Projection Arborization Cell Surface Receptor Signaling Pathway Regulation Of Ossification COPII Vesicle Coating Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Localization SMAD Protein Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Developmental Growth Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cellular Developmental Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytosol Endoderm Development MiRNA Processing Vesicle Coating Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Ureteric Bud Development Negative Regulation Of Ossification Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Cellular Component Organization Mesonephric Epithelium Development	Negative Regulation Of Transcription By Competitive Promoter Binding Protein Lysine Deacetylase Activity Histone Deacetylase Activity, Hydrolytic Mechanism Sin3-type Complex Histone Deacetylase Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cardiac Muscle Hypertrophy Muscle Hypertrophy Regulation Of Myoblast Proliferation DNA-binding Transcription Activator Activity Muscle System Process Histone Deacetylase Complex Regulation Of Cell Population Proliferation Regulation Of Myotube Differentiation Skeletal Muscle Cell Differentiation Positive Regulation Of Male Mating Behavior Promoter-specific Chromatin Binding Regulation Of Myoblast Differentiation Regulation Of Striated Muscle Cell Differentiation Cellular Response To Lipid Protein De-2-hydroxyisobutyrylase Activity Myoblast Fate Determination Negative Regulation Of Relaxation Of Cardiac Muscle Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Histone Deacetylase Binding Protein Lysine Delactylase Activity Fungiform Papilla Formation Skeletal Muscle Fiber Adaptation Negative Regulation Of Myoblast Proliferation Protein Decrotonylase Activity Histone Decrotonylase Activity Positive Regulation Of SnRNA Transcription By RNA Polymerase II Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Muscle Cell Differentiation Positive Regulation Of Aggrephagy Hair Follicle Placode Formation Histone Binding Negative Regulation Of Gene Expression, Epigenetic Regulation Of Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Hydrolase Activity Protein Metabolic Process Protein Modification Process DNA-binding Transcription Factor Binding Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Dopamine
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