RIT1 and AFDN

Number of citations of the paper that reports this interaction (PubMedID 10545207)
0

Data Source:
HPRD (two hybrid)

		RIT1	AFDN
Description		Ras like without CAAX 1	afadin, adherens junction formation factor
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Nuclear Speck Cell Junction Cell-cell Contact Zone Pore Complex Tight Junction Anchoring Junction
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding	Protein Binding Small GTPase Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Cell Adhesion Signal Transduction Cell-cell Signaling Positive Regulation Of Gene Expression Positive Regulation Of Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Regulation Of Protein Localization Cell Junction Organization Cell-cell Adhesion Mediated By Cadherin Pore Complex Assembly Establishment Of Protein Localization To Plasma Membrane Bicellular Tight Junction Assembly Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		Signalling to p38 via RIT and RIN
Drugs			(5R)-2-sulfanyl-5-[4-(trifluoromethyl)benzyl]-1,3-thiazol-4(5H)-one
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Number of alcoholic drinks required to feel an effect (long-term average) ( 31270906)
Interacting Genes		16 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2	39 interacting genes: BCR CTNNA1 DSCAM EPHA7 EPHB2 EPHB3 EPHB6 F11R HRAS JAG1 LMO2 MRAS NECTIN1 NECTIN2 NECTIN3 NECTIN4 NRXN1 NRXN2 NRXN3 PFN1 PICK1 RALGDS RAP1A RAP1GAP RAP2A RIN1 RIT1 RIT2 RNF10 RRAS RRAS2 SMAD2 SORBS1 SORBS2 SSX2IP TJP1 USP9X YWHAB YWHAG
Entrez ID		6016	4301
HPRD ID		10195	01164
Ensembl ID		ENSG00000143622	ENSG00000130396
Uniprot IDs		Q92963	A0A1P7ZIN0 A0A804HJ20 A8MQ02 G1UI22 J3KN01 P55196
PDB IDs		4KLZ	1T2M 1XZ9 2AIN 2EXG 5A6C 7QCR
Enriched GO Terms of Interacting Partners?		I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Signal Transduction Wnt Signaling Pathway Paraxial Mesoderm Morphogenesis R-SMAD Binding Intracellular Signaling Cassette Mesoderm Morphogenesis Gastrulation Pericardium Development SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Tissue Development Regulation Of Neuron Projection Development Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Ras Protein Signal Transduction Positive Regulation Of Gene Expression Primary MiRNA Processing Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Neuron Projection Arborization Cell Surface Receptor Signaling Pathway Regulation Of Ossification COPII Vesicle Coating Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Localization SMAD Protein Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Developmental Growth Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cellular Developmental Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytosol Endoderm Development MiRNA Processing Vesicle Coating Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Ureteric Bud Development Negative Regulation Of Ossification Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Cellular Component Organization Mesonephric Epithelium Development	Signal Transduction GDP Binding Regulation Of Cell Junction Assembly Plasma Membrane Small GTPase-mediated Signal Transduction Cell Adhesion Ras Protein Signal Transduction Cell-cell Adhesion Cell Adhesion Molecule Binding Membrane Regulation Of Synapse Assembly Adherens Junction G Protein Activity Regulation Of Plasma Membrane Bounded Cell Projection Organization Anchoring Junction Ephrin Receptor Activity Regulation Of Cell Projection Organization Transmembrane-ephrin Receptor Activity Neuron Projection Guidance Axon Guidance Protein Localization To Cell Junction GTPase Activity Plasma Membrane Bounded Cell Projection Organization Cell Junction Organization Neuroligin Family Protein Binding Synapse Regulation Of Cellular Component Organization Cell Junction Assembly Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Membrane Assembly Intracellular Signaling Cassette Regulation Of Synapse Organization Focal Adhesion Negative Regulation Of Cellular Component Organization Apical Junction Complex Regulation Of Locomotion Zonula Adherens Presynaptic Membrane Cell Projection Organization Postsynaptic Membrane Organization Dendrite Regulation Of Cell Projection Assembly Neuron Projection Development GTP Binding Axon Guidance Receptor Activity Cell Adhesion Mediator Activity Regulation Of Cell Motility Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
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