RIT1 and RALGDS

Number of citations of the paper that reports this interaction (PMID 10545207)
18

Data Source:
HPRD (two hybrid)

		RIT1	RALGDS
Gene Name		Ras-like without CAAX 1	ral guanine nucleotide dissociation stimulator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane	Nucleus Cytosol Brush Border
	Molecular Function	Protein Binding Calmodulin Binding GTP Binding	Small GTPase Regulator Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway	Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN	Signalling to ERKs Signalling by NGF Signalling to RAS p38MAPK events NGF signalling via TRKA from the plasma membrane
Drugs
Diseases
GWAS		Conduct disorder (interaction) ( 18846501) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		14 interactors: AP2A1 CUL3 IFRD1 KLHL12 LRIF1 MLLT4 PTN RALGDS RGL1 RLF SMAD2 SMAD3 SMURF1 SRPK2	23 interactors: ARRB1 ARRB2 CD68 CNKSR1 HRAS KRAS LRPAP1 MAPK3 MLLT4 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		6016	5900
HPRD ID		10195	03371
Ensembl ID		ENSG00000143622	ENSG00000160271
Uniprot IDs		Q92963	B7Z753 E7ER93 E7ERZ0 Q12967 Q6PCE1 Q6ZSD5 Q8N4Y1
PDB IDs			1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?		Signal Transduction Signaling Cell Communication Primary MiRNA Processing Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Signaling Paraxial Mesoderm Morphogenesis Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Signal Transduction Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Nodal Signaling Pathway Regulation Of Metabolic Process Embryonic Foregut Morphogenesis Foregut Morphogenesis Paraxial Mesoderm Development COPII Vesicle Coating Anatomical Structure Development Transforming Growth Factor Beta Receptor Signaling Pathway Production Of MiRNAs Involved In Gene Silencing By MiRNA COPII-coated Vesicle Budding Pericardium Development Regulation Of Cell Proliferation Response To Stimulus Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Transforming Growth Factor Beta Stimulus Vesicle Targeting, To, From Or Within Golgi Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Gastrulation Developmental Process In Utero Embryonic Development Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of Metabolic Process Posttranscriptional Gene Silencing Protein Monoubiquitination Vesicle Targeting Localization Within Membrane	Ras Protein Signal Transduction Small GTPase Mediated Signal Transduction Rap Protein Signal Transduction Neurotrophin Signaling Pathway Positive Regulation Of Rap GTPase Activity Regulation Of MAPK Cascade Regulation Of ERK1 And ERK2 Cascade Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Protein Phosphorylation Regulation Of Rap Protein Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Signal Transduction Response To Growth Factor Positive Regulation Of Phosphorylation Blood Coagulation Regulation Of Phosphorus Metabolic Process Hemostasis Positive Regulation Of Protein Modification Process Signaling Cellular Response To Stimulus Cell Communication Platelet Activation Regulation Of Signaling Neurotrophin TRK Receptor Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Wound Healing Regulation Of Catalytic Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Synaptic Transmission Response To Wounding Regulation Of Protein Kinase Activity Establishment Of Endothelial Barrier Response To Stimulus Regulation Of GTPase Activity Regulation Of Kinase Activity Positive Regulation Of Metabolic Process Epithelial Cell Development Regulation Of Cell Migration Positive Regulation Of Catalytic Activity Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		aberrations adenocarcinoma adenocarcinomas copy driver eighteen exclusive explained focal foundation highlighted megabase messenger met mga microrna mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic splicing unexplained worldwide	abi1 atlas bitbucket ccnd3 ctnnd1 doi driver drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 regulatorygenomicsupf signatures splicing switches transcript
Tagcloud (Difference) ?		aberrations adenocarcinoma adenocarcinomas copy eighteen exclusive explained focal foundation highlighted megabase messenger met mga microrna mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic unexplained worldwide	abi1 atlas bitbucket ccnd3 ctnnd1 doi drivers dx fbln2 figshare hindered http https identifies implies isoform ktsp m9 mitf myh11 org pparg prdm1 regulatorygenomicsupf signatures switches transcript
Tagcloud (Intersection) ?		driver splicing