RIT1 and RALGDS

Number of citations of the paper that reports this interaction (PubMedID 10545207)
0

Data Source:
HPRD (two hybrid)

		RIT1	RALGDS
Description		Ras like without CAAX 1	ral guanine nucleotide dissociation stimulator
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Brush Border
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Signal Transduction Ras Protein Signal Transduction	Signal Transduction Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction
Pathways		Signalling to p38 via RIT and RIN	p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		16 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2	26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		6016	5900
HPRD ID		10195	03371
Ensembl ID		ENSG00000143622	ENSG00000160271
Uniprot IDs		Q92963	Q12967 Q8N4Y1
PDB IDs		4KLZ	1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?		I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Signal Transduction Wnt Signaling Pathway Paraxial Mesoderm Morphogenesis R-SMAD Binding Intracellular Signaling Cassette Mesoderm Morphogenesis Gastrulation Pericardium Development SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Tissue Development Regulation Of Neuron Projection Development Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Ras Protein Signal Transduction Positive Regulation Of Gene Expression Primary MiRNA Processing Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Neuron Projection Arborization Cell Surface Receptor Signaling Pathway Regulation Of Ossification COPII Vesicle Coating Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Localization SMAD Protein Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Developmental Growth Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cellular Developmental Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytosol Endoderm Development MiRNA Processing Vesicle Coating Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Ureteric Bud Development Negative Regulation Of Ossification Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Cellular Component Organization Mesonephric Epithelium Development	GDP Binding G Protein Activity Small GTPase-mediated Signal Transduction Intracellular Signaling Cassette GTPase Activity Ras Protein Signal Transduction Rap Protein Signal Transduction GTP Binding Intracellular Signal Transduction Plasma Membrane Signal Transduction Regulation Of MAPK Cascade Establishment Of Endothelial Barrier Regulation Of Vesicle-mediated Transport Endothelial Cell Development Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cellular Component Organization Epithelial Cell Development Positive Regulation Of MAPK Cascade Regulation Of Intracellular Signal Transduction Regulation Of Microvillus Assembly Nucleotide Binding Positive Regulation Of Vasculogenesis Regulation Of Cell Migration MAPK Cascade Establishment Of Endothelial Intestinal Barrier Regulation Of Cell Motility Regulation Of Vasculogenesis Angiotensin Receptor Binding Regulation Of Locomotion Cell Development Positive Regulation Of Intracellular Signal Transduction Regulation Of Endocytosis Schwann Cell Migration Modulation Of Chemical Synaptic Transmission Regulation Of Signal Transduction Membrane Hydrolase Activity Actin Cytoskeleton Organization Positive Regulation Of Cell Projection Organization Positive Regulation Of Cell Migration Positive Regulation Of Microvillus Assembly Positive Regulation Of Cell Motility Regulation Of Cell Projection Assembly Positive Regulation Of Locomotion Regulation Of Cellular Component Organization Anchoring Junction Actin Filament-based Process Desensitization Of G Protein-coupled Receptor Signaling Pathway
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