AP2A1 and DEK

Number of citations of the paper that reports this interaction (PMID 12595566)
25

Data Source:
HPRD (in vivo, in vitro)

		AP2A1	DEK
Gene Name		adaptor-related protein complex 2, alpha 1 subunit	DEK proto-oncogene
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Nucleus Contractile Fiber
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	DNA Binding Histone Binding Poly(A) RNA Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Chromatin Modification Viral Genome Replication Regulation Of Double-strand Break Repair Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Trafficking of GluR2-containing AMPA receptors Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AMPH AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 MYO6 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1	10 interactors: AP2A1 CREBBP CSNK2A1 EP300 HIST3H3 HLA-A KAT2B SRRM1 TFAP2A ZIK1
Entrez ID		160	7913
HPRD ID		03016	00503
Ensembl ID		ENSG00000196961	ENSG00000124795
Uniprot IDs		O95782	B4DFG0 P35659
PDB IDs			1Q1V 2JX3
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Establishment Of Localization In Cell Synaptic Vesicle Transport Cellular Localization Regulation Of Vesicle-mediated Transport Membrane Budding Transport Cellular Protein Complex Assembly Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Synaptic Transmission Signaling Membrane Organization Cell Communication Cellular Macromolecular Complex Assembly Cell-cell Signaling Establishment Of Organelle Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Endocytosis Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Organelle Localization Neuron Development Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Protein Complex Assembly Positive Regulation Of Transport Secretion By Cell Cellular Component Assembly Receptor Internalization Neuron Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of ERBB Signaling Pathway Generation Of Neurons Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Priming ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurogenesis Secretion Neuron Projection Morphogenesis Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	N-terminal Peptidyl-lysine Acetylation N-terminal Protein Amino Acid Acetylation N-terminal Protein Amino Acid Modification Viral Process Rhythmic Process Transcription, DNA-templated RNA Biosynthetic Process Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Notch Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Defense Response To Virus By Virus Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Regulation Of Cellular Response To Heat Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Cellular Macromolecule Biosynthetic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Macromolecule Biosynthetic Process Negative Regulation Of ERBB Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Nitrogen Compound Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Transcription From RNA Polymerase II Promoter Cellular Response To Heat Positive Regulation Of Cytokine Production Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Histone H2B Acetylation Optic Cup Structural Organization Positive Regulation Of Type I Interferon Production Histone Modification Regulation Of ERBB Signaling Pathway Regulation Of Defense Response To Virus Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Oculomotor Nerve Formation Positive Regulation Of Memory T Cell Activation Optic Vesicle Morphogenesis
Tagcloud ?			abnormality basophils biomolecular chimaeric chromosomal cml continuously doubled eosinophils fkh granulocyte heterogenous leukaemia leukaemogenesis morphologies multilineage myelocytic myeloid myelomonocytic oft p23 permanent ph1 philadelphia pluripotent proliferating q34 rarely transcript
Tagcloud (Difference) ?			abnormality basophils biomolecular chimaeric chromosomal cml continuously doubled eosinophils fkh granulocyte heterogenous leukaemia leukaemogenesis morphologies multilineage myelocytic myeloid myelomonocytic oft p23 permanent ph1 philadelphia pluripotent proliferating q34 rarely transcript
Tagcloud (Intersection) ?