RIT1 and RLF

Number of citations of the paper that reports this interaction (PMID 10545207)
18

Data Source:
BioGRID (pull down)
HPRD (two hybrid)

		RIT1	RLF
Gene Name		Ras-like without CAAX 1	rearranged L-myc fusion
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane	Nucleus
	Molecular Function	Protein Binding Calmodulin Binding GTP Binding	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Signal Transduction Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Neurotrophin TRK Receptor Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated DNA Integration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization
Pathways		Signalling to ERKs Signalling by NGF NGF signalling via TRKA from the plasma membrane Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Conduct disorder (interaction) ( 18846501) Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		14 interactors: AP2A1 CUL3 IFRD1 KLHL12 LRIF1 MLLT4 PTN RALGDS RGL1 RLF SMAD2 SMAD3 SMURF1 SRPK2	4 interactors: GCH1 PRPF40A RIT1 RIT2
Entrez ID		6016	6018
HPRD ID		10195	01614
Ensembl ID		ENSG00000143622	ENSG00000117000
Uniprot IDs		Q92963	Q13129
PDB IDs
Enriched GO Terms of Interacting Partners?		Signal Transduction Signaling Cell Communication Primary MiRNA Processing Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Signaling Paraxial Mesoderm Morphogenesis Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Signal Transduction Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Nodal Signaling Pathway Regulation Of Metabolic Process Embryonic Foregut Morphogenesis Foregut Morphogenesis Paraxial Mesoderm Development COPII Vesicle Coating Anatomical Structure Development Transforming Growth Factor Beta Receptor Signaling Pathway Production Of MiRNAs Involved In Gene Silencing By MiRNA COPII-coated Vesicle Budding Pericardium Development Regulation Of Cell Proliferation Response To Stimulus Signal Transduction Involved In Regulation Of Gene Expression Cellular Response To Transforming Growth Factor Beta Stimulus Vesicle Targeting, To, From Or Within Golgi Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Gastrulation Developmental Process In Utero Embryonic Development Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of Metabolic Process Posttranscriptional Gene Silencing Protein Monoubiquitination Vesicle Targeting Localization Within Membrane	Olfactory Bulb Axon Guidance Striatal Medium Spiny Neuron Differentiation 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Regulation Of Lung Blood Pressure Dihydrobiopterin Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Tetrahydrofolate Biosynthetic Process Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Tetrahydrobiopterin Biosynthetic Process T Cell Receptor V(D)J Recombination Post-embryonic Camera-type Eye Development Keratinocyte Development Dopamine Biosynthetic Process Nitric Oxide Biosynthetic Process Striatum Development Neuromuscular Process Controlling Posture Positive Regulation Of Nitric-oxide Synthase Activity Forebrain Neuron Fate Commitment Catecholamine Biosynthetic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Keratinocyte Proliferation Tetrahydrofolate Metabolic Process Subpallium Development Small GTPase Mediated Signal Transduction Positive Regulation Of Monooxygenase Activity Response To Organic Substance Positive T Cell Selection Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Dopamine Metabolic Process Nitric Oxide Metabolic Process V(D)J Recombination Folic Acid-containing Compound Biosynthetic Process Reactive Nitrogen Species Metabolic Process Vasodilation Pteridine-containing Compound Biosynthetic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Oxidoreductase Activity Response To Pain T Cell Selection Catecholamine Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Folic Acid-containing Compound Metabolic Process Negative Regulation Of Blood Pressure Epithelial Cell Morphogenesis Pteridine-containing Compound Metabolic Process Regulation Of Cytokinesis Thymus Development Alpha-beta T Cell Differentiation
Tagcloud ?		aberrations adenocarcinoma adenocarcinomas copy driver eighteen exclusive explained focal foundation highlighted megabase messenger met mga microrna mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic splicing unexplained worldwide	adjusted adjustment adults advance august died doi ejcn european examination journal lifestyle nlf nmol nutrition obstruction obstructive oh olf online participated prevalent publication restrictive sociodemographic spirometric us worse
Tagcloud (Difference) ?		aberrations adenocarcinoma adenocarcinomas copy driver eighteen exclusive explained focal foundation highlighted megabase messenger met mga microrna mutually nf1 oncogene otherwise profiling proteomic rbm10 resected skipping somatic splicing unexplained worldwide	adjusted adjustment adults advance august died doi ejcn european examination journal lifestyle nlf nmol nutrition obstruction obstructive oh olf online participated prevalent publication restrictive sociodemographic spirometric us worse
Tagcloud (Intersection) ?