AP2A1 and SYT3

Number of citations of the paper that reports this interaction (PMID 7791877)
118

Data Source:
HPRD (in vitro)

		AP2A1	SYT3
Gene Name		adaptor-related protein complex 2, alpha 1 subunit	synaptotagmin III
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Endosome Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	Phosphatidylserine Binding Transporter Activity Calcium-dependent Phospholipid Binding Syntaxin Binding Clathrin Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Calcium Ion-dependent Exocytosis Positive Regulation Of Vesicle Fusion Response To Calcium Ion
Pathways		Trafficking of GluR2-containing AMPA receptors Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AMPH AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 MYO6 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1	4 interactors: AP2A1 SNAP25 SYNCRIP SYT5
Entrez ID		160	84258
HPRD ID		03016	08977
Ensembl ID		ENSG00000196961	ENSG00000213023
Uniprot IDs		O95782	Q9BQG1
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Establishment Of Localization In Cell Synaptic Vesicle Transport Cellular Localization Regulation Of Vesicle-mediated Transport Membrane Budding Transport Cellular Protein Complex Assembly Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Synaptic Transmission Signaling Membrane Organization Cell Communication Cellular Macromolecular Complex Assembly Cell-cell Signaling Establishment Of Organelle Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Endocytosis Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Organelle Localization Neuron Development Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Protein Complex Assembly Positive Regulation Of Transport Secretion By Cell Cellular Component Assembly Receptor Internalization Neuron Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of ERBB Signaling Pathway Generation Of Neurons Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Priming ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurogenesis Secretion Neuron Projection Morphogenesis Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	Synaptic Transmission Energy Reserve Metabolic Process Cell-cell Signaling Regulation Of Insulin Secretion Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion CRD-mediated MRNA Stabilization Vesicle-mediated Transport Energy Derivation By Oxidation Of Organic Compounds Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Regulation Of Protein Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Generation Of Precursor Metabolites And Energy Neurotransmitter Uptake Establishment Of Localization In Cell Secretion By Cell Golgi To Endosome Transport Viral Process Cellular Localization Regulation Of Protein Transport Glutamate Secretion Secretion Regulation Of Defense Response To Virus By Virus Regulation Of Secretion MRNA Stabilization Regulation Of Establishment Of Protein Localization Clathrin-mediated Endocytosis Regulation Of Protein Localization Calcium Ion-dependent Exocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of ERBB Signaling Pathway Long-term Synaptic Potentiation Vesicle Fusion Regulation Of MRNA Stability Synaptic Vesicle Exocytosis Regulation Of RNA Stability Acid Secretion Vesicle Docking Involved In Exocytosis Cell Differentiation Regulation Of Cellular Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Fusion Regulation Of ERBB Signaling Pathway Vesicle Docking Regulation Of Defense Response To Virus Dicarboxylic Acid Transport
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