AP2A1 and SYT3

Number of citations of the paper that reports this interaction (PubMedID 7791877)
0

Data Source:
HPRD (in vitro)

		AP2A1	SYT3
Description		adaptor related protein complex 2 subunit alpha 1	synaptotagmin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Membrane Coat AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Adaptor Complex Clathrin-coated Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Filopodium Tip Protein-containing Complex Endolysosome Membrane Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Glutamatergic Synapse	Endosome Plasma Membrane Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Synapse Exocytic Vesicle
	Molecular Function	Protein Binding Protein Kinase Binding Clathrin Adaptor Activity Protein-containing Complex Binding Low-density Lipoprotein Particle Receptor Binding	SNARE Binding Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding Calcium Ion Sensor Activity
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Hyaluronan Biosynthetic Process	Chemical Synaptic Transmission Vesicle-mediated Transport Regulation Of Calcium Ion-dependent Exocytosis Cell Differentiation Positive Regulation Of Vesicle Fusion Positive Regulation Of Dendrite Extension
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Adult body size ( 32376654) Superior frontal gyrus volume ( 31530798) Waist circumference ( 28552196)
Interacting Genes		29 interacting genes: AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 DSCAM DUX4 EHD1 EPN1 EPS15 GHR HIP1 NAGPA NUMB PICALM PIN1 PLK2 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1 UBC	9 interacting genes: AP2A1 GRIA2 IQSEC1 KCNJ6 MRM1 SNAP25 SNCA SYNCRIP SYT5
Entrez ID		160	84258
HPRD ID		03016	08977
Ensembl ID		ENSG00000196961	ENSG00000213023
Uniprot IDs		O95782	Q9BQG1
PDB IDs
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Vesicle-mediated Transport Clathrin Binding Clathrin Coat Assembly Clathrin-coated Pit Clathrin-coated Vesicle Phospholipid Binding Receptor Internalization Clathrin Coat Of Coated Pit Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Endosome Protein-containing Complex Assembly Phosphatidylinositol-4,5-bisphosphate Binding Ciliary Pocket Membrane Protein-containing Complex Organization Receptor-mediated Endocytosis Plasma Membrane Regulation Of Endocytosis Synaptic Vesicle Endocytosis Presynapse Presynaptic Endocytosis Regulation Of Amyloid-beta Formation Tau Protein Binding Cytoplasmic Vesicle Postsynaptic Neurotransmitter Receptor Internalization Endomembrane System Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Clathrin Vesicle Coat Ciliary Membrane Establishment Of Localization In Cell AP-2 Adaptor Complex Cytosol Establishment Of Protein Localization Vesicle Organization Cadherin Binding SNARE Binding Lipid Binding Endocytic Vesicle Membrane Cellular Component Assembly Glutamatergic Synapse Protein Transport Regulation Of Amide Metabolic Process Synaptic Vesicle Priming Membrane Clathrin Adaptor Activity Calcium Ion Sensor Activity Organelle Organization	Synaptic Vesicle SNARE Binding Postsynaptic Endocytic Zone Vesicle-mediated Transport In Synapse Chemical Synaptic Transmission Trans-synaptic Signaling Synaptic Signaling Synaptic Vesicle Priming Synapse Positive Regulation Of Vesicle Fusion Modulation Of Chemical Synaptic Transmission Neurotransmitter Uptake Synaptic Vesicle Exocytosis Regulation Of Vesicle Fusion Import Into Cell Synaptic Vesicle Endocytosis Signaling Cell-cell Signaling Neurotransmitter Secretion Presynaptic Endocytosis Cell Communication Long-term Synaptic Potentiation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Receptor Internalization Regulation Of Transport Lipid Binding Endocytic Vesicle Membrane Neuronal Cell Body Voltage-gated Potassium Channel Complex Regulation Of Neurotransmitter Secretion Axon Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process RRNA (guanosine-2'-O-)-methyltransferase Activity Regulation Of Postsynaptic Membrane Potential Neurotransmitter Transport Response To Type II Interferon Regulated Exocytosis Establishment Of Vesicle Localization Ligand-gated Monoatomic Cation Channel Activity Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Proximal Neuron Projection RRNA (guanine) Methyltransferase Activity
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