AP2A1 and SNAP29

Number of citations of the paper that reports this interaction (PMID 11423532)
33

Data Source:
HPRD (in vitro, in vivo)

		AP2A1	SNAP29
Gene Name		adaptor-related protein complex 2, alpha 1 subunit	synaptosomal-associated protein, 29kDa
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Cytoplasm Centrosome Plasma Membrane Cell Junction SNARE Complex Neuron Projection Synapse
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	SNAP Receptor Activity Syntaxin Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Autophagic Vacuole Fusion Exocytosis Vesicle Targeting Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Membrane Fusion
Pathways		Trafficking of GluR2-containing AMPA receptors Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AMPH AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 MYO6 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1	22 interactors: AP2A1 ATF4 CD7 EHD1 EHD3 FAM9B ITSN2 KIFC3 LURAP1 RASSF7 STX12 STX17 STX1A STX3 STX4 STX6 STX7 VAMP1 VAMP2 VAMP4 VAMP5 VAMP7
Entrez ID		160	9342
HPRD ID		03016	11968
Ensembl ID		ENSG00000196961	ENSG00000099940
Uniprot IDs		O95782	O95721
PDB IDs
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Establishment Of Localization In Cell Synaptic Vesicle Transport Cellular Localization Regulation Of Vesicle-mediated Transport Membrane Budding Transport Cellular Protein Complex Assembly Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Synaptic Transmission Signaling Membrane Organization Cell Communication Cellular Macromolecular Complex Assembly Cell-cell Signaling Establishment Of Organelle Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Endocytosis Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Organelle Localization Neuron Development Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Protein Complex Assembly Positive Regulation Of Transport Secretion By Cell Cellular Component Assembly Receptor Internalization Neuron Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of ERBB Signaling Pathway Generation Of Neurons Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Priming ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurogenesis Secretion Neuron Projection Morphogenesis Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	Vesicle Fusion Organelle Fusion Membrane Fusion Vesicle Organization Vesicle-mediated Transport Membrane Organization Intracellular Protein Transport Establishment Of Localization In Cell Cellular Protein Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Cellular Localization Vesicle Docking SNARE Complex Assembly Membrane Docking Exocytosis Protein Localization Endomembrane System Organization Golgi Vesicle Transport Secretion By Cell Post-Golgi Vesicle-mediated Transport Organelle Organization Neurotransmitter Secretion Secretion Transport Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Neurotransmitter Levels Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Exocytosis Regulation Of Protein Localization Neurotransmitter Transport Golgi Organization Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization To Plasma Membrane Endosomal Transport Golgi To Plasma Membrane Protein Transport Regulation Of Cellular Localization Eosinophil Degranulation Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission Golgi To Plasma Membrane Transport Calcium Ion-dependent Exocytosis Protein Localization To Plasma Membrane Regulation Of Exocytosis Long-term Synaptic Potentiation Golgi Ribbon Formation Protein Complex Assembly Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Exocytosis
Tagcloud ?			92e accumulates architecture asparagine autophagic autophagosomes cednik dispensable distinctive dysgenesis highlighting hop hopscotch ichthyosis keratoderma localizes neuropathy npf nsf organelles palmoplantar phenylalanine routes snare stat92e synaptosomal trafficking uncharacterized unlikely
Tagcloud (Difference) ?			92e accumulates architecture asparagine autophagic autophagosomes cednik dispensable distinctive dysgenesis highlighting hop hopscotch ichthyosis keratoderma localizes neuropathy npf nsf organelles palmoplantar phenylalanine routes snare stat92e synaptosomal trafficking uncharacterized unlikely
Tagcloud (Intersection) ?