RIT1 and CUL3

Number of citations of the paper that reports this interaction (PubMedID 18303015)
39

Data Source:
HPRD (in vivo)

		RIT1	CUL3
Description		Ras like without CAAX 1	cullin 3
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Spindle Polar Microtubule Cytosol Cytoskeleton Plasma Membrane Cilium Membrane Cullin-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Motile Cilium Sperm Flagellum Cell Projection Extracellular Exosome Mitotic Spindle Postsynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding Calmodulin Binding GTP Binding Hydrolase Activity GDP Binding	Ubiquitin-protein Transferase Activity Notch Binding Protein Binding Cyclin Binding POZ Domain Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Ubiquitin Protein Ligase Activity Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Signal Transduction Ras Protein Signal Transduction	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Mitotic Cell Cycle Cell Morphogenesis In Utero Embryonic Development Kidney Development Trophectodermal Cellular Morphogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Apoptotic Process Response To Stress Inflammatory Response Response To Oxidative Stress Mitotic Metaphase Chromosome Alignment Signal Transduction Integrin-mediated Signaling Pathway Gastrulation Positive Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Wnt Signaling Pathway Vesicle-mediated Transport Cell Migration Protein Ubiquitination Stem Cell Division Cell Projection Organization Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Cellular Response To Nutrient Levels Positive Regulation Of Cytokinesis Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Negative Regulation Of Rho Protein Signal Transduction Embryonic Cleavage Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fibroblast Apoptotic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition COPII Vesicle Coating Cell Division Protein Autoubiquitination Type I Interferon-mediated Signaling Pathway Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Cellular Response To Amino Acid Stimulus Nuclear Protein Quality Control By The Ubiquitin-proteasome System Liver Morphogenesis Regulation Of Primary Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Protein Catabolic Process At Postsynapse RNA Polymerase II Transcription Initiation Surveillance Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling
Pathways		Signalling to p38 via RIT and RIN	Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle Potential therapeutics for SARS RHOBTB3 ATPase cycle KEAP1-NFE2L2 pathway Antigen processing: Ubiquitination & Proteasome degradation SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 23128233 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)	Acute graft versus host disease in bone marrow transplantation (recipient effect) ( 27595289) Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) General risk tolerance (MTAG) ( 30643258) Response to bupropion and depression ( 27622933) Schizophrenia ( 25056061 28991256 29483656 30285260) Sensorimotor dexterity ( 31596458) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		16 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2	66 interacting genes: ABTB1 ABTB2 ARHGEF12 BTBD10 BTBD2 BTBD3 BTBD6 CAMK1D CAND1 CCND1 CCNE1 CDC25A CDC34 CEBPA CLK1 COMMD1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 DYRK4 EFNB1 FOLR1 GABARAP GABARAPL1 GABARAPL2 GLUD1 GMCL1 GPS1 HLA-DMB HSF2 KCTD10 KCTD11 KCTD7 KLHL12 KLHL22 KLHL42 KLHL6 MAP1LC3B MAP1LC3C MAT2A MTNR1A MTNR1B NEDD8 OLIG2 PDIA2 PDPK1 RBBP8 RBX1 RCBTB1 RHOBTB3 RIT1 RNF7 SHKBP1 SNX6 SUMO2 SUMO3 UBASH3B UBC UBE2D1 UBE2D2 UBE2E1 UBE2E2 UBE2E3 WNT7B ZMAT4
Entrez ID		6016	8452
HPRD ID		10195	09123
Ensembl ID		ENSG00000143622	ENSG00000036257
Uniprot IDs		Q92963	B7Z600 Q13618
PDB IDs		4KLZ	2MYL 2MYM 4AP2 4APF 4EOZ 4HXI 5NLB 6I2M 8GQ6 8H33 8H34 8H35 8H36 8H37 8H38 8H3A 8H3F 8H3Q 8H3R 8I79 8K8T 8K9I 8KHP 8U80 8U81 8U82 8U83 8U84
Enriched GO Terms of Interacting Partners?		I-SMAD Binding Transforming Growth Factor Beta Receptor Binding Signal Transduction Wnt Signaling Pathway Paraxial Mesoderm Morphogenesis R-SMAD Binding Intracellular Signaling Cassette Mesoderm Morphogenesis Gastrulation Pericardium Development SMAD Protein Complex Trophoblast Cell Migration Heteromeric SMAD Protein Complex Tissue Development Regulation Of Neuron Projection Development Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Ras Protein Signal Transduction Positive Regulation Of Gene Expression Primary MiRNA Processing Intracellular Signal Transduction Small GTPase-mediated Signal Transduction Neuron Projection Arborization Cell Surface Receptor Signaling Pathway Regulation Of Ossification COPII Vesicle Coating Regulation Of Plasma Membrane Bounded Cell Projection Organization Cellular Localization SMAD Protein Signal Transduction Regulation Of Cell Projection Organization Positive Regulation Of Cellular Component Organization Developmental Growth Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Cellular Developmental Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cytosol Endoderm Development MiRNA Processing Vesicle Coating Cell Differentiation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Ureteric Bud Development Negative Regulation Of Ossification Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of Cellular Component Organization Mesonephric Epithelium Development	Protein Modification By Small Protein Conjugation Protein Neddylation Post-translational Protein Modification Cellular Response To Nitrogen Starvation Protein Modification Process Cullin Family Protein Binding Ubiquitin-like Protein Binding Positive Regulation Of Protein Neddylation Phosphatidylethanolamine Binding Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Regulation Of Protein Neddylation Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Protein Monoubiquitination Cul3-RING Ubiquitin Ligase Complex Mitophagy Protein K48-linked Ubiquitination Protein Tag Activity Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Autophagy Of Mitochondrion Response To Nutrient Levels Proteolysis Involved In Protein Catabolic Process Regulation Of Post-translational Protein Modification Cellular Response To Starvation Ubiquitin-protein Transferase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Autophagosome Maturation Protein Metabolic Process Protein Polyubiquitination Cytoplasm Autophagosome Assembly Autophagosome Membrane Response To Starvation Autophagosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Binding Ubiquitin Conjugating Enzyme Binding Macromolecule Catabolic Process Autophagosome Proteasomal Protein Catabolic Process Nucleus Mitotic Cell Cycle Phase Transition GABA Receptor Binding Cytosol Macroautophagy
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