AP2A1 and EHD1

Number of citations of the paper that reports this interaction (PubMedID 11423532)
0

Data Source:
BioGRID (pull down)

		AP2A1	EHD1
Description		adaptor related protein complex 2 subunit alpha 1	EH domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Membrane Coat AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Adaptor Complex Clathrin-coated Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Filopodium Tip Protein-containing Complex Endolysosome Membrane Clathrin-coated Endocytic Vesicle Postsynaptic Endocytic Zone Glutamatergic Synapse	Cytoplasm Endosome Early Endosome Lipid Droplet Plasma Membrane Cilium Endosome Membrane Membrane Ciliary Pocket Membrane Endocytic Vesicle Platelet Dense Tubular Network Membrane Early Endosome Membrane Cell Projection Perinuclear Region Of Cytoplasm Presynaptic Active Zone Recycling Endosome Membrane Ciliary Membrane Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Kinase Binding Clathrin Adaptor Activity Protein-containing Complex Binding Low-density Lipoprotein Particle Receptor Binding	Nucleotide Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding Cadherin Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Positive Regulation Of Neuron Projection Development Protein Transport Vesicle-mediated Transport Positive Regulation Of Receptor-mediated Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Hyaluronan Biosynthetic Process	Intracellular Protein Transport Endocytosis Positive Regulation Of Cholesterol Storage Positive Regulation Of Neuron Projection Development Protein Transport Endosomal Transport Cell Projection Organization Neuron Projection Development Endocytic Recycling Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Protein Homooligomerization Cilium Assembly Protein Localization To Cilium Protein Localization To Plasma Membrane Positive Regulation Of Myoblast Fusion Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Endocytic Recycling
Pathways		Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Trafficking of GluR2-containing AMPA receptors Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)
Interacting Genes		29 interacting genes: AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 DSCAM DUX4 EHD1 EPN1 EPS15 GHR HIP1 NAGPA NUMB PICALM PIN1 PLK2 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1 UBC	13 interacting genes: AP2A1 EHBP1 EHD3 HSPB1 IGF1R MICAL1 MUL1 OGT PACSIN2 RAB11FIP2 RBSN RFFL SNAP29
Entrez ID		160	10938
HPRD ID		03016	09325
Ensembl ID		ENSG00000196961	ENSG00000110047
Uniprot IDs		O95782	A0A024R571 B2R5U3 Q9H4M9
PDB IDs			2JQ6 2KFF 2KFG 2KFH 2KSP
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Vesicle-mediated Transport Clathrin Binding Clathrin Coat Assembly Clathrin-coated Pit Clathrin-coated Vesicle Phospholipid Binding Receptor Internalization Clathrin Coat Of Coated Pit Vesicle-mediated Transport In Synapse Regulation Of Vesicle-mediated Transport Endosome Protein-containing Complex Assembly Phosphatidylinositol-4,5-bisphosphate Binding Ciliary Pocket Membrane Protein-containing Complex Organization Receptor-mediated Endocytosis Plasma Membrane Regulation Of Endocytosis Synaptic Vesicle Endocytosis Presynapse Presynaptic Endocytosis Regulation Of Amyloid-beta Formation Tau Protein Binding Cytoplasmic Vesicle Postsynaptic Neurotransmitter Receptor Internalization Endomembrane System Regulation Of Cellular Component Organization Regulation Of Amyloid Precursor Protein Catabolic Process Clathrin Vesicle Coat Ciliary Membrane Establishment Of Localization In Cell AP-2 Adaptor Complex Cytosol Establishment Of Protein Localization Vesicle Organization Cadherin Binding SNARE Binding Lipid Binding Endocytic Vesicle Membrane Cellular Component Assembly Glutamatergic Synapse Protein Transport Regulation Of Amide Metabolic Process Synaptic Vesicle Priming Membrane Clathrin Adaptor Activity Calcium Ion Sensor Activity Organelle Organization	Intracellular Protein Localization Vesicle-mediated Transport Protein Transport Endosome Establishment Of Protein Localization Recycling Endosome Membrane Plasma Membrane Ciliary Pocket Membrane Protein Kinase Binding Endocytosis Golgi To Lysosome Transport Cilium Endosome Membrane Import Into Cell Post-Golgi Vesicle-mediated Transport Early Endosome To Golgi Transport Regulation Of Golgi Organization Golgi To Vacuole Transport Cytosolic Transport Membrane Establishment Of Localization In Cell Negative Regulation Of Protein Kinase C Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Ciliary Membrane Cytosol Regulation Of Cellular Component Organization Cellular Response To Glucose Stimulus Golgi Vesicle Transport Small GTPase Binding Intracellular Transport P53 Binding Cellular Response To Carbohydrate Stimulus Sulfur Oxidation Hippocampal Mossy Fiber Expansion Cell Projection Early Endosome Negative Regulation Of Intracellular Signal Transduction Protein Kinase C Inhibitor Activity Insulin-like Growth Factor Receptor Activity Protein Kinase Complex Intracellular Glucose Homeostasis Insulin Receptor Activity Protein O-acetylglucosaminyltransferase Activity TRAM-dependent Toll-like Receptor 4 Signaling Pathway F-actin Monooxygenase Activity Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Retrograde Transport, Endosome To Golgi Positive Regulation Of Cold-induced Thermogenesis
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