AP2A1 and EHD1

Number of citations of the paper that reports this interaction (PMID 11423532)
33

Data Source:
BioGRID (pull down)

		AP2A1	EHD1
Gene Name		adaptor-related protein complex 2, alpha 1 subunit	EH-domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane AP-2 Adaptor Complex Clathrin Coat Of Trans-Golgi Network Vesicle Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane	Lipid Particle Plasma Membrane Endosome Membrane Membrane Platelet Dense Tubular Network Membrane Early Endosome Membrane Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Protein Transporter Activity Protein Kinase Binding Clathrin Adaptor Activity	Calcium Ion Binding Protein Binding ATP Binding GTP Binding Rab GTPase Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process	Intracellular Protein Transport Endocytosis Blood Coagulation Positive Regulation Of Cholesterol Storage Neuron Projection Development Endocytic Recycling Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Protein Homooligomerization Positive Regulation Of Myoblast Fusion Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Endocytic Recycling
Pathways		Trafficking of GluR2-containing AMPA receptors Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Trafficking of AMPA receptors beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity PCP/CE pathway Adaptive Immune System Transmission across Chemical Synapses	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: AMPH AP2S1 BIN1 CLINT1 DEK DNM2 DPYSL2 EHD1 EPN1 EPS15 GHR HIP1 MYO6 NAGPA NUMB PICALM PIN1 RAB11FIP2 RIT1 SHBG SHC1 SMAD9 SNAP29 SYNJ1 SYT3 SYT7 TOE1	12 interactors: ANKFY1 AP2A1 CLTC EHBP1 EHD3 IGF1R MICAL1 MICALL1 PLA2G4A RAB11FIP2 RBSN SNAP29
Entrez ID		160	10938
HPRD ID		03016	09325
Ensembl ID		ENSG00000196961	ENSG00000110047
Uniprot IDs		O95782	B2R5U3 Q9H4M9
PDB IDs			2JQ6 2KFF 2KFG 2KFH 2KSP
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Clathrin Coat Assembly Establishment Of Localization In Cell Synaptic Vesicle Transport Cellular Localization Regulation Of Vesicle-mediated Transport Membrane Budding Transport Cellular Protein Complex Assembly Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Synaptic Transmission Signaling Membrane Organization Cell Communication Cellular Macromolecular Complex Assembly Cell-cell Signaling Establishment Of Organelle Localization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Regulation Of Endocytosis Regulation Of ERBB Signaling Pathway Regulation Of Cellular Component Organization Organelle Localization Neuron Development Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Protein Complex Assembly Positive Regulation Of Transport Secretion By Cell Cellular Component Assembly Receptor Internalization Neuron Differentiation Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Projection Organization Negative Regulation Of ERBB Signaling Pathway Generation Of Neurons Exocytosis Epidermal Growth Factor Receptor Signaling Pathway Synaptic Vesicle Priming ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Neurogenesis Secretion Neuron Projection Morphogenesis Response To Stimulus Cellular Response To Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway	Vesicle-mediated Transport Negative Regulation Of Hyaluronan Biosynthetic Process Endosomal Transport Establishment Of Localization In Cell Post-Golgi Vesicle-mediated Transport Protein Transport Establishment Of Protein Localization Cellular Localization Membrane Organization Endocytic Recycling Protein Localization Endocytosis Transport Golgi Vesicle Transport Intracellular Transport Vesicle Fusion Receptor-mediated Endocytosis Intracellular Protein Transport Inactivation Of MAPKK Activity Slow Endocytic Recycling Organelle Fusion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Establishment Of Cell Polarity Endosomal Vesicle Fusion Golgi To Lysosome Transport Positive Regulation Of Pinocytosis Membrane Fusion Regulation Of Body Fluid Levels Cellular Protein Localization Platelet Activating Factor Biosynthetic Process Regulation Of Carbohydrate Metabolic Process Secretion Protein Targeting To Membrane Platelet Activating Factor Metabolic Process Insulin Secretion Involved In Cellular Response To Glucose Stimulus Establishment Or Maintenance Of Cell Polarity Endosome Localization Cardiolipin Acyl-chain Remodeling Sulfur Oxidation Positive Regulation Of Steroid Hormone Biosynthetic Process Exocrine Pancreas Development Golgi To Vacuole Transport Vesicle Organization Autophagic Vacuole Fusion Protein Localization To Endosome Regulation Of Cardiac Muscle Cell Membrane Potential Plasma Membrane Organization Synaptic Vesicle Priming
Tagcloud ?			accurate complex2 date1 encode flowering h3k27me3 hd3a heading involve ld oslf photoperiod polycomb prc2 presently promotion repressed repression repressive repressor rft1 rice sd sdg711 sdg718 trimethylation z zeste
Tagcloud (Difference) ?			accurate complex2 date1 encode flowering h3k27me3 hd3a heading involve ld oslf photoperiod polycomb prc2 presently promotion repressed repression repressive repressor rft1 rice sd sdg711 sdg718 trimethylation z zeste
Tagcloud (Intersection) ?