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AP2A1
Gene Name
adaptor-related protein complex 2, alpha 1 subunit
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytosol
Plasma Membrane
Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
AP-2 Adaptor Complex
Clathrin Coat Of Trans-Golgi Network Vesicle
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Molecular Function
Protein Binding
Protein C-terminus Binding
Protein Transporter Activity
Protein Kinase Binding
Clathrin Adaptor Activity
Biological Process
Intracellular Protein Transport
Golgi To Endosome Transport
Endocytosis
Epidermal Growth Factor Receptor Signaling Pathway
Synaptic Transmission
Axon Guidance
Viral Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Regulation Of Defense Response To Virus By Virus
Clathrin-mediated Endocytosis
Negative Regulation Of Hyaluronan Biosynthetic Process
Pathways
Trafficking of GluR2-containing AMPA receptors
Retrograde neurotrophin signalling
Axon guidance
HIV Infection
Nef Mediated CD8 Down-regulation
L1CAM interactions
Signaling by Wnt
Signaling by EGFRvIII in Cancer
Recycling pathway of L1
EPH-ephrin mediated repulsion of cells
MHC class II antigen presentation
EPH-Ephrin signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Nef Mediated CD4 Down-regulation
EGFR downregulation
Signalling by NGF
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
Host Interactions of HIV factors
Signaling by Ligand-Responsive EGFR Variants in Cancer
The role of Nef in HIV-1 replication and disease pathogenesis
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Trafficking of AMPA receptors
beta-catenin independent WNT signaling
Signaling by EGFR
WNT5A-dependent internalization of FZD4
Signaling by EGFR in Cancer
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
PCP/CE pathway
Adaptive Immune System
Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-protein Interactions
27 interactors:
AMPH
AP2S1
BIN1
CLINT1
DEK
DNM2
DPYSL2
EHD1
EPN1
EPS15
GHR
HIP1
MYO6
NAGPA
NUMB
PICALM
PIN1
RAB11FIP2
RIT1
SHBG
SHC1
SMAD9
SNAP29
SYNJ1
SYT3
SYT7
TOE1
Entrez ID
160
HPRD ID
03016
Ensembl ID
ENSG00000196961
Uniprot IDs
O95782
PDB IDs
Enriched GO Terms of Interacting Partners
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Vesicle-mediated Transport
Endocytosis
Clathrin Coat Assembly
Establishment Of Localization In Cell
Synaptic Vesicle Transport
Cellular Localization
Regulation Of Vesicle-mediated Transport
Membrane Budding
Transport
Cellular Protein Complex Assembly
Establishment Of Vesicle Localization
Vesicle Organization
Vesicle Localization
Synaptic Transmission
Signaling
Membrane Organization
Cell Communication
Cellular Macromolecular Complex Assembly
Cell-cell Signaling
Establishment Of Organelle Localization
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Regulation Of Endocytosis
Regulation Of ERBB Signaling Pathway
Regulation Of Cellular Component Organization
Organelle Localization
Neuron Development
Synaptic Vesicle Endocytosis
Synaptic Vesicle Recycling
Protein Complex Assembly
Positive Regulation Of Transport
Secretion By Cell
Cellular Component Assembly
Receptor Internalization
Neuron Differentiation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Cell Projection Organization
Negative Regulation Of ERBB Signaling Pathway
Generation Of Neurons
Exocytosis
Epidermal Growth Factor Receptor Signaling Pathway
Synaptic Vesicle Priming
ERBB Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Neurogenesis
Secretion
Neuron Projection Morphogenesis
Response To Stimulus
Cellular Response To Stimulus
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
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