Wiki-Pi
About
Search
People
Updates
Search
PDGFRB and NEDD4
Number of citations of the paper that reports this interaction (PubMedID
19953087
)
60
Data Source:
BioGRID
(enzymatic study, pull down)
PDGFRB
NEDD4
Description
platelet derived growth factor receptor beta
NEDD4 E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Plasma Membrane
Focal Adhesion
Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Receptor Complex
Ubiquitin Ligase Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Cell Cortex
Membrane
Apicolateral Plasma Membrane
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Postsynaptic Cytosol
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
GTPase Activator Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Platelet-derived Growth Factor Binding
Phospholipase C Activator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Channel Inhibitor Activity
Transferase Activity
Potassium Channel Inhibitor Activity
Sodium Channel Inhibitor Activity
Enzyme Binding
Protein Domain Specific Binding
Beta-2 Adrenergic Receptor Binding
Ionotropic Glutamate Receptor Binding
Ubiquitin Binding
Transmembrane Transporter Binding
Phosphoserine Residue Binding
Phosphothreonine Residue Binding
Ubiquitin Protein Ligase Activity
RNA Polymerase Binding
Proline-rich Region Binding
Biological Process
Angiogenesis
Chemotaxis
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Smooth Muscle Adaptation
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Regulation Of Actin Cytoskeleton Organization
Cell Migration Involved In Vasculogenesis
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Mitotic Nuclear Division
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Calcium-mediated Signaling
Positive Regulation Of Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Myofibril Assembly
Cell Chemotaxis
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Adaptive Immune Response
Outflow Tract Morphogenesis
Endocardial Cushion Development
Transcription By RNA Polymerase II
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Targeting To Lysosome
Sodium Ion Transport
Immune Response
DNA Damage Response
Lysosomal Transport
Nervous System Development
Neuromuscular Junction Development
Regulation Of Cell Communication
Negative Regulation Of Sodium Ion Transport
Regulation Of Macroautophagy
Protein Ubiquitination
Regulation Of Signaling
Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neuron Projection Development
Receptor Internalization
Receptor Catabolic Process
Cellular Response To UV
T Cell Activation
Regulation Of Protein Catabolic Process
Regulation Of Membrane Potential
Nuclear Receptor-mediated Glucocorticoid Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Formation Of Structure Involved In A Symbiotic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Viral Budding
Positive Regulation Of Nucleocytoplasmic Transport
Blood Vessel Morphogenesis
Regulation Of Dendrite Morphogenesis
Regulation Of Synapse Organization
Progesterone Receptor Signaling Pathway
Response To Calcium Ion
Establishment Of Localization In Cell
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Biological Quality
Protein K63-linked Ubiquitination
Negative Regulation Of Potassium Ion Export Across Plasma Membrane
Pathways
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ISG15 antiviral mechanism
Downregulation of ERBB4 signaling
Regulation of PTEN localization
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Tivozanib
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
Diseases
Glioma
GWAS
Blood protein levels (
30072576
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
27863252
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Appendicular lean mass (
33097823
)
Brain connectivity (
23471985
)
Chronic lymphocytic leukemia (
24292274
28165464
)
Dupuytren's disease (
28886342
)
Hip circumference adjusted for BMI (
28552196
)
Intraocular pressure (
29617998
)
Joint mobility (Beighton score) (
27182965
)
Keloid (
20711176
)
Refractive error (
32231278
)
Interacting Genes
78 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CEP76
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
LCOR
NCK1
NCK2
NEDD4
NHERF1
NHERF2
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SNX1
SNX2
SNX27
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TYK2
VAV1
YES1
282 interacting genes:
ABCB1
ABL1
ABL2
ADRB2
AK6
AKT1
AKT3
AMOT
AMOTL1
AMPD2
ANK3
ANKRD13D
ANXA13
AP1G2
ARID1A
ASPSCR1
AURKC
BAIAP2
BAIAP2L1
BIRC6
BMPR1A
C15orf62
CAD
CALCOCO1
CAMK1D
CAMK4
CAMKK2
CASP1
CASP3
CASP6
CASP7
CBLB
CCNH
CDC25C
CDIP1
CDK5
CDK5R1
CLIC2
CLK3
CPSF1
CPSF6
CRTC2
CUEDC1
DAZAP2
DCUN1D1
DDN
DDX3X
DDX54
DHX30
DIAPH1
DVL1
DYRK4
EBAG9
EGFR
EGR1
ENTREP1
EP300
EPHA5
EPRS1
EPS15
ERBB3
ERBB4
ERMN
ERRFI1
ESS2
FES
FGF12
FGF21
FGFR1
FGFR2
FKBP3
FLT1
FLT4
FOXJ3
FYN
GABARAP
GABARAPL1
GABARAPL2
GBA1
GFUS
GJA1
GRB10
GRIN2A
GRK4
GRK7
H3-3A
HGS
HMCES
HMGCL
HNRNPK
HNRNPL
HNRNPU
HNRNPUL1
HRAS
IFITM3
IGF1R
IL1B
IRS1
IRS2
JHY
JUN
KCNAB1
KCNAB2
KCNJ16
KIFC3
KLF5
KRAS
LATS1
LDLRAD3
LDLRAD4
LINC01198
LITAF
LUC7L2
MAML2
MAP1LC3A
MAP1LC3B
MAP1LC3C
MAP3K2
MAP3K3
MAP3K5
MAP4K5
MAPKAPK3
MARK2
MARK4
MLANA
MOB3A
MRPL19
MS4A10
MTMR4
MYCN
MYCT1
MYO15B
N4BP2
N4BP3
NDFIP1
NDFIP2
NFE2
NHP2
NRAS
NSRP1
NUDT21
NUMB
PARP16
PAX7
PDGFRB
PIP4P2
PIP5K1A
PIP5K1C
PKN2
PLK1
PLK2
PMEPA1
POLR1C
POLR2A
POLR2C
POLR2E
POLR2M
POLR3A
PRKG2
PRKX
PRPF8
PRR16
PRR7
PRRG2
PRRG4
PSMD4
PTEN
PYM1
RAC1
RAD51AP1
RAF1
RANBP10
RAP2A
RAPGEF2
RAPGEF6
RASGEF1A
RASL11B
RBCK1
RBM14
RET
RFT1
RHBDD1
RHBDD2
RNF11
RNF38
RNF7
RPAP2
RPAP3
RPL18A
RPS3A
RPS6KA3
RPS6KA4
RPS6KB1
RUVBL1
SAAL1
SAMSN1
SAV1
SCAMP3
SCN10A
SCN1A
SCN5A
SCNN1A
SCNN1B
SCNN1G
SEPTIN9
SFTPC
SGK1
SGK2
SH3KBP1
SHISA6
SHTN1
SIVA1
SLC23A2
SLC6A3
SMAD1
SMAD3
SMAD5
SMARCC1
SMO
SNCA
SP140L
SPANXN3
SPRY2
SQSTM1
SRC
SRMS
SRSF7
STK24
STK25
STK26
STK31
STK4
STRIP2
SULF1
SYK
SYNPO2
SYT1
TAF1B
TBC1D7
TCEANC
TCP11L1
TEAD2
TGFB1I1
THOC1
THRAP3
TMEM139
TMEM252
TMEM51
TNIK
TOM1
TOM1L2
TP53BP2
TP63
TP73
TRERF1
TRIM44
TRIM52
TRPV6
TTYH2
TTYH3
TULP4
TUSC2
UBAP2L
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2L3
UBE2L6
UBE2M
UBOX5
URI1
UVRAG
VDAC2
VDAC3
WBP1
WBP2
WEE1
YES1
YOD1
ZC3H14
Entrez ID
5159
4734
HPRD ID
01423
03786
Ensembl ID
ENSG00000113721
ENSG00000069869
Uniprot IDs
P09619
Q59F04
P46934
PDB IDs
1GQ5
1H9O
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
2KPZ
2KQ0
2M3O
2XBB
2XBF
3B7Y
4BBN
4BE8
4N7F
4N7H
5AHT
5C7J
5C91
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Cell Adhesion
ERBB Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Cytosol
Positive Regulation Of Cell Adhesion
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Multicellular Organismal Process
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Insulin Receptor Signaling Pathway
Regulation Of Cell-cell Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Migration
Growth Hormone Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Locomotion
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Migration
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of T Cell Activation
Regulation Of Programmed Cell Death
Regulation Of Cell Motility
Regulation Of Immune System Process
Positive Regulation Of Cell Motility
T Cell Activation
Cell Activation
Ephrin Receptor Binding
Receptor Tyrosine Kinase Binding
Positive Regulation Of Locomotion
Positive Regulation Of T Cell Activation
Cell Migration
Response To Growth Factor
Positive Regulation Of Multicellular Organismal Process
Regulation Of Biological Quality
Protein Kinase Activity
Kinase Activity
Protein Phosphorylation
Intracellular Signal Transduction
ATP Binding
Nucleotide Binding
Phosphorylation
WW Domain Binding
Protein Serine/threonine Kinase Activity
Protein Tyrosine Kinase Activity
Transferase Activity
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Protein Serine Kinase Activity
Enzyme-linked Receptor Protein Signaling Pathway
Protein Autophosphorylation
Signal Transduction
Cytoplasm
Regulation Of Protein Modification Process
Protein Modification Process
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
MAPK Cascade
Positive Regulation Of Metabolic Process
Peptidyl-tyrosine Phosphorylation
Macromolecule Metabolic Process
Positive Regulation Of Cell Communication
Apoptotic Process
Intracellular Signaling Cassette
Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Cellular Component Organization
Cellular Response To Oxygen-containing Compound
Regulation Of Signal Transduction
Positive Regulation Of Signaling
Cytosol
Regulation Of Intracellular Signal Transduction
Regulation Of Programmed Cell Death
Programmed Cell Death
Cell Surface Receptor Signaling Pathway
Cell Death
Regulation Of Apoptotic Process
Nucleoplasm
Regulation Of Biological Quality
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Projection Organization
Response To Growth Factor
Positive Regulation Of Cellular Component Organization
Regulation Of Cell Motility
Regulation Of Locomotion
Regulation Of Cell Communication
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?