Wiki-Pi
About
Search
People
Updates
Search
PDGFRB and SNX4
Number of citations of the paper that reports this interaction (PubMedID
9819414
)
41
Data Source:
HPRD
(in vitro)
PDGFRB
SNX4
Description
platelet derived growth factor receptor beta
sorting nexin 4
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Lysosome
Golgi Apparatus
Plasma Membrane
Focal Adhesion
Membrane
Apical Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Receptor Complex
Cytoplasm
Endosome
Early Endosome
Cytoplasmic Dynein Complex
Plasma Membrane
Membrane
SNARE Complex
Early Endosome Membrane
Protein-containing Complex
Presynaptic Endosome
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
GTPase Activator Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Platelet-derived Growth Factor Binding
Phospholipase C Activator Activity
Epidermal Growth Factor Receptor Binding
Insulin Receptor Binding
Protein Binding
Lipid Binding
Phosphatidylinositol-3-phosphate Binding
Phosphatidylinositol Binding
Transferrin Receptor Binding
Leptin Receptor Binding
Biological Process
Angiogenesis
Chemotaxis
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Smooth Muscle Adaptation
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Regulation Of Actin Cytoskeleton Organization
Cell Migration Involved In Vasculogenesis
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Mitotic Nuclear Division
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Calcium-mediated Signaling
Positive Regulation Of Chemotaxis
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cardiac Myofibril Assembly
Cell Chemotaxis
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Protein Transport
Endocytic Recycling
Positive Regulation Of Histamine Secretion By Mast Cell
Positive Regulation Of Autophagosome Assembly
Pathways
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Tivozanib
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
Diseases
Glioma
GWAS
Blood protein levels (
30072576
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
27863252
32888494
)
Monocyte percentage of white cells (
27863252
32888494
)
Adult body size (
32376654
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Major depressive disorder x sex interaction (
34099189
)
Urate levels (
31578528
)
Interacting Genes
78 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CEP76
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
LCOR
NCK1
NCK2
NEDD4
NHERF1
NHERF2
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SNX1
SNX2
SNX27
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TYK2
VAV1
YES1
18 interacting genes:
AGK
ARL6IP1
ATP6V0A1
BIN1
DGAT2L6
EGFR
HIVEP1
INSR
LEPR
MAGEA6
OGT
PDGFRA
PDGFRB
PTPN5
SH3GLB1
SNX2
SNX6
SUPT5H
Entrez ID
5159
8723
HPRD ID
01423
09334
Ensembl ID
ENSG00000113721
ENSG00000114520
Uniprot IDs
P09619
Q59F04
O95219
PDB IDs
1GQ5
1H9O
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Phosphotyrosine Residue Binding
Regulation Of Cell Adhesion
ERBB Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Intracellular Signal Transduction
Cytosol
Positive Regulation Of Cell Adhesion
Non-membrane Spanning Protein Tyrosine Kinase Activity
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Positive Regulation Of Signal Transduction
Protein Tyrosine Kinase Activity
Regulation Of Signal Transduction
Regulation Of MAPK Cascade
Regulation Of Multicellular Organismal Process
Intracellular Signal Transduction
Regulation Of Signaling
Regulation Of Cell Communication
Insulin Receptor Signaling Pathway
Regulation Of Cell-cell Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Cell Migration
Growth Hormone Receptor Signaling Pathway
Regulation Of Apoptotic Process
Regulation Of Locomotion
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Migration
Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of T Cell Activation
Regulation Of Programmed Cell Death
Regulation Of Cell Motility
Regulation Of Immune System Process
Positive Regulation Of Cell Motility
T Cell Activation
Cell Activation
Ephrin Receptor Binding
Receptor Tyrosine Kinase Binding
Positive Regulation Of Locomotion
Positive Regulation Of T Cell Activation
Cell Migration
Response To Growth Factor
Positive Regulation Of Multicellular Organismal Process
Regulation Of Biological Quality
Transmembrane Receptor Protein Tyrosine Kinase Activity
Regulation Of Autophagy
Receptor Complex
Phospholipase C Activator Activity
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Metanephric Glomerular Capillary Formation
Vascular Endothelial Growth Factor Binding
Retromer, Tubulation Complex
Protein Tyrosine Kinase Activity
Glomerular Capillary Formation
Lipid Binding
Regulation Of Macroautophagy
Platelet-derived Growth Factor Binding
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Platelet-derived Growth Factor Receptor Binding
Retina Vasculature Development In Camera-type Eye
Cardiac Myofibril Assembly
Regulation Of Glucose Metabolic Process
Cellular Response To Growth Factor Stimulus
Vascular Endothelial Growth Factor Signaling Pathway
Endosome Membrane
Membrane
Retromer Complex
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphorus Metabolic Process
Protein Autophosphorylation
Response To Growth Factor
Adrenal Gland Development
Kinase Activity
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Myofibril Assembly
Negative Regulation Of ERBB Signaling Pathway
Cellular Localization
Negative Regulation Of Catabolic Process
Phosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Cell Cycle Process
Endosome
Lipid Tube
Negative Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Regulation Of Organelle Organization
Protein-containing Complex
Positive Regulation Of ERK1 And ERK2 Cascade
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Multivesicular Body, Internal Vesicle Lumen
Leptin Receptor Activity
Platelet-derived Growth Factor Alpha-receptor Activity
Cell Migration Involved In Coronary Angiogenesis
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?